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Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden.
Eur Respir J. 2016 Apr; 47(4):1208-18.ER

Abstract

The effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm County, Sweden, PCV7 was introduced in the childhood immunisation programme in 2007 and changed to PCV13 in 2010.Over 90% of all invasive isolates during 2005-2014 (n=2336) and carriage isolates, 260 before and 647 after vaccine introduction, were characterised by serotyping, molecular typing and antibiotic susceptibility, and serotype diversity was calculated. Clinical information was collected for children and adults with invasive pneumococcal disease (IPD).The IPD incidence decreased post-PCV7, but not post-PCV13, in vaccinated children. Beneficial herd effects were seen in older children and adults, but not in the elderly. The herd protection was more pronounced post-PCV7 than post-PCV13. PCV7 serotypes decreased. IPD caused by PCV13 serotypes 3 and 19A increased post-PCV7. Post-PCV13, serotypes 6A and 19A, but not serotype 3, decreased. The serotype distribution changed in carriage and IPD to nonvaccine types, also in nonvaccinated populations. Expansion of non-PCV13 serotypes was largest following PCV13 introduction. Serotype diversity increased and nonvaccine clones emerged, such as CC433 (serotype 22F) in IPD and CC62 (serotype 11A) in carriage. In young children, meningitis, septicaemia and severe rhinosinusitis, but not bacteraemic pneumonia, decreased.Pneumococcal vaccination leads to expansion of new or minor serotypes/clones, also in nonvaccinated populations.

Authors+Show Affiliations

Public Health Agency of Sweden, Solna, Sweden These authors contributed equally to this article.Public Health Agency of Sweden, Solna, Sweden Dept of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden These authors contributed equally to this article.Public Health Agency of Sweden, Solna, Sweden These authors contributed equally to this article.Dept of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden Dept of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.Dept of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.Public Health Agency of Sweden, Solna, Sweden.Public Health Agency of Sweden, Solna, Sweden.Dept of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden Dept of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.Sachs' Children's Hospital, South General Hospital, Stockholm, Sweden Dept of Clinical Sciences and Education, Karolinska Institutet, Stockholm, Sweden.Dept of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden Dept of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden These authors contributed equally to this article.Public Health Agency of Sweden, Solna, Sweden Dept of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden Dept of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden These authors contributed equally to this article birgitta.henriques@ki.se.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26797033

Citation

Galanis, Ilias, et al. "Effects of PCV7 and PCV13 On Invasive Pneumococcal Disease and Carriage in Stockholm, Sweden." The European Respiratory Journal, vol. 47, no. 4, 2016, pp. 1208-18.
Galanis I, Lindstrand A, Darenberg J, et al. Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden. Eur Respir J. 2016;47(4):1208-18.
Galanis, I., Lindstrand, A., Darenberg, J., Browall, S., Nannapaneni, P., Sjöström, K., Morfeldt, E., Naucler, P., Blennow, M., Örtqvist, Å., & Henriques-Normark, B. (2016). Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden. The European Respiratory Journal, 47(4), 1208-18. https://doi.org/10.1183/13993003.01451-2015
Galanis I, et al. Effects of PCV7 and PCV13 On Invasive Pneumococcal Disease and Carriage in Stockholm, Sweden. Eur Respir J. 2016;47(4):1208-18. PubMed PMID: 26797033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden. AU - Galanis,Ilias, AU - Lindstrand,Ann, AU - Darenberg,Jessica, AU - Browall,Sarah, AU - Nannapaneni,Priyanka, AU - Sjöström,Karin, AU - Morfeldt,Eva, AU - Naucler,Pontus, AU - Blennow,Margareta, AU - Örtqvist,Åke, AU - Henriques-Normark,Birgitta, Y1 - 2016/01/21/ PY - 2015/08/31/received PY - 2015/12/01/accepted PY - 2016/1/23/entrez PY - 2016/1/23/pubmed PY - 2017/2/10/medline SP - 1208 EP - 18 JF - The European respiratory journal JO - Eur Respir J VL - 47 IS - 4 N2 - The effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm County, Sweden, PCV7 was introduced in the childhood immunisation programme in 2007 and changed to PCV13 in 2010.Over 90% of all invasive isolates during 2005-2014 (n=2336) and carriage isolates, 260 before and 647 after vaccine introduction, were characterised by serotyping, molecular typing and antibiotic susceptibility, and serotype diversity was calculated. Clinical information was collected for children and adults with invasive pneumococcal disease (IPD).The IPD incidence decreased post-PCV7, but not post-PCV13, in vaccinated children. Beneficial herd effects were seen in older children and adults, but not in the elderly. The herd protection was more pronounced post-PCV7 than post-PCV13. PCV7 serotypes decreased. IPD caused by PCV13 serotypes 3 and 19A increased post-PCV7. Post-PCV13, serotypes 6A and 19A, but not serotype 3, decreased. The serotype distribution changed in carriage and IPD to nonvaccine types, also in nonvaccinated populations. Expansion of non-PCV13 serotypes was largest following PCV13 introduction. Serotype diversity increased and nonvaccine clones emerged, such as CC433 (serotype 22F) in IPD and CC62 (serotype 11A) in carriage. In young children, meningitis, septicaemia and severe rhinosinusitis, but not bacteraemic pneumonia, decreased.Pneumococcal vaccination leads to expansion of new or minor serotypes/clones, also in nonvaccinated populations. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/26797033/Effects_of_PCV7_and_PCV13_on_invasive_pneumococcal_disease_and_carriage_in_Stockholm_Sweden_ DB - PRIME DP - Unbound Medicine ER -