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Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial.
Nutrients 2016; 8(1)N

Abstract

BACKGROUND

Cardiovascular disease is the leading cause of worldwide morbidity and mortality. Several studies have demonstrated that specific probiotics affect the host's metabolism and may influence the cardiovascular disease risk.

OBJECTIVES

The aim of this study was to investigate the influence of an isoflavone-supplemented soy product fermented with Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 on cardiovascular risk markers in moderately hypercholesterolemic subjects.

DESIGN

Randomized placebo-controlled double-blind trial Setting: São Paulo State University in Araraquara, SP, Brazil.

PARTICIPANTS

49 male healthy men with total cholesterol (TC) >5.17 mmol/L and <6.21 mmol/L Intervention: The volunteers have consumed 200 mL of the probiotic soy product (group SP-10(10) CFU/day), isoflavone-supplemented probiotic soy product (group ISP-probiotic plus 50 mg of total isoflavones/100 g) or unfermented soy product (group USP-placebo) for 42 days in a randomized, double-blind study.

MAIN OUTCOME MEASURES

Lipid profile and additional cardiovascular biomarkers were analyzed on days 0, 30 and 42. Urine samples (24 h) were collected at baseline and at the end of the experiment so as to determine the isoflavones profile.

RESULTS

After 42 days, the ISP consumption led to improved total cholesterol, non-HDL-C (LDL + IDL + VLDL cholesterol fractions) and electronegative LDL concentrations (reduction of 13.8%, 14.7% and 24.2%, respectively, p < 0.05). The ISP and SP have prevented the reduction of HDL-C level after 42 days. The C-reactive protein and fibrinogen levels were not improved. The equol production by the ISP group subjects was inversely correlated with electronegative LDL concentration.

CONCLUSIONS

The results suggest that a regular consumption of this probiotic soy product, supplemented with isoflavones, could contribute to reducing the risk of cardiovascular diseases in moderately hypercholesterolemic men, through the an improvement in lipid profile and antioxidant properties.

Authors+Show Affiliations

Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. cavallinidc@fcfar.unesp.br.Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. mamanzoni@hotmail.com.Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508900, Brazil. raquelbedani@yahoo.com.br.Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. mari_roselino@yahoo.com.br.Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. larissasbaglia@gmail.com.Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. vendrasp@fcfar.unesp.br.Reference Center for Lactobacilli, CERELA, S.M. Tucuman T4000ILC, Argentina. gfont@cerela.org.ar.Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo 05508900, Brazil. dspabdalla@gmail.com.Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. rosely@fcfar.unesp.br.Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, UNESP -Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. daniella.rossetto@gmail.com.Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, UNESP -Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. valentsr@fcfar.unesp.br.Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP 14801-902, Brasil. rossiea@fcfar.unesp.br.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26797632

Citation

Cavallini, Daniela Cardoso Umbelino, et al. "Probiotic Soy Product Supplemented With Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: a Randomized Controlled Trial." Nutrients, vol. 8, no. 1, 2016.
Cavallini DC, Manzoni MS, Bedani R, et al. Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial. Nutrients. 2016;8(1).
Cavallini, D. C., Manzoni, M. S., Bedani, R., Roselino, M. N., Celiberto, L. S., Vendramini, R. C., ... Rossi, E. A. (2016). Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial. Nutrients, 8(1), doi:10.3390/nu8010052.
Cavallini DC, et al. Probiotic Soy Product Supplemented With Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: a Randomized Controlled Trial. Nutrients. 2016 Jan 19;8(1) PubMed PMID: 26797632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial. AU - Cavallini,Daniela Cardoso Umbelino, AU - Manzoni,Marla Simone Jovenasso, AU - Bedani,Raquel, AU - Roselino,Mariana Nougalli, AU - Celiberto,Larissa Sbaglia, AU - Vendramini,Regina Célia, AU - de Valdez,Graciela Font, AU - Abdalla,Dulcinéia Saes Parra, AU - Pinto,Roseli Aparecida, AU - Rosetto,Daniella, AU - Valentini,Sandro Roberto, AU - Rossi,Elizeu Antonio, Y1 - 2016/01/19/ PY - 2015/10/08/received PY - 2015/12/03/revised PY - 2015/12/16/accepted PY - 2016/1/23/entrez PY - 2016/1/23/pubmed PY - 2016/9/30/medline KW - Enterococcus faecium CRL183 KW - fermented soy product KW - isoflavones KW - lipid profile KW - probiotic JF - Nutrients JO - Nutrients VL - 8 IS - 1 N2 - BACKGROUND: Cardiovascular disease is the leading cause of worldwide morbidity and mortality. Several studies have demonstrated that specific probiotics affect the host's metabolism and may influence the cardiovascular disease risk. OBJECTIVES: The aim of this study was to investigate the influence of an isoflavone-supplemented soy product fermented with Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 on cardiovascular risk markers in moderately hypercholesterolemic subjects. DESIGN: Randomized placebo-controlled double-blind trial Setting: São Paulo State University in Araraquara, SP, Brazil. PARTICIPANTS: 49 male healthy men with total cholesterol (TC) >5.17 mmol/L and <6.21 mmol/L Intervention: The volunteers have consumed 200 mL of the probiotic soy product (group SP-10(10) CFU/day), isoflavone-supplemented probiotic soy product (group ISP-probiotic plus 50 mg of total isoflavones/100 g) or unfermented soy product (group USP-placebo) for 42 days in a randomized, double-blind study. MAIN OUTCOME MEASURES: Lipid profile and additional cardiovascular biomarkers were analyzed on days 0, 30 and 42. Urine samples (24 h) were collected at baseline and at the end of the experiment so as to determine the isoflavones profile. RESULTS: After 42 days, the ISP consumption led to improved total cholesterol, non-HDL-C (LDL + IDL + VLDL cholesterol fractions) and electronegative LDL concentrations (reduction of 13.8%, 14.7% and 24.2%, respectively, p < 0.05). The ISP and SP have prevented the reduction of HDL-C level after 42 days. The C-reactive protein and fibrinogen levels were not improved. The equol production by the ISP group subjects was inversely correlated with electronegative LDL concentration. CONCLUSIONS: The results suggest that a regular consumption of this probiotic soy product, supplemented with isoflavones, could contribute to reducing the risk of cardiovascular diseases in moderately hypercholesterolemic men, through the an improvement in lipid profile and antioxidant properties. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26797632/Probiotic_Soy_Product_Supplemented_with_Isoflavones_Improves_the_Lipid_Profile_of_Moderately_Hypercholesterolemic_Men:_A_Randomized_Controlled_Trial_ L2 - http://www.mdpi.com/resolver?pii=nu8010052 DB - PRIME DP - Unbound Medicine ER -