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Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins.
Psychoneuroendocrinology. 2016 Apr; 66:91-100.P

Abstract

INTRODUCTION

By and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion may vary according to the time of day. A direct test of this possibility has, however, not yet been performed.

OBJECTIVE

To describe the specific and common etiology of the CAR, awakening level and cortisol change from morning to evening in an age-homogenous sample of twin adolescents.

METHODS

A total of 592 participants of the Québec Newborn Twin Study, a population-based 1995-1998 cohort of families with twins in Canada, have collected saliva at awakening, 30 min later, at the end of afternoon and in the evening over four collection days.

RESULTS

Multivariate Cholesky models showed both specific and common sources of variance between the CAR, awakening and cortisol diurnal change. The CAR had the strongest heritability estimates, which, for the most part, did not overlap with the other indicators. Conversely, similar magnitudes of genetic and environmental contributions were detected at awakening and for diurnal change, which partially overlapped.

CONCLUSION

Our study unraveled differences between the latent etiologies of the CAR and the rest of the diurnal cycle, which may contribute to identify regulatory genes and environments and detangle how these indicators each relate to physical and mental health.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ouellet-Morin I
School of Criminology, University of Montreal, Montreal, Canada; Research Center of the Montreal Mental Health University Institute, Montreal, Canada. Electronic address: isabelle.ouellet-morin@umontreal.ca.
Brendgen M
Department of Psychology, University of Quebec a Montreal, Montreal, Canada; Sainte-Justine Hospital Research Center, Montreal, Canada.
Girard A
Sainte-Justine Hospital Research Center, Montreal, Canada.
Lupien SJ
Research Center of the Montreal Mental Health University Institute, Montreal, Canada; Department Psychiatry, University of Montreal, Montreal, Canada.
Dionne G
Department of Psychology, Laval University, Quebec, Canada.
Vitaro F
Sainte-Justine Hospital Research Center, Montreal, Canada; School of Psychoéducation, Université de Montreal, Montreal, Canada.
Boivin M
Department of Psychology, Laval University, Quebec, Canada; Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Russian Federation.

MeSH

AdolescentAdultCircadian RhythmCohort StudiesFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemQuebecSalivaStress, PhysiologicalTime FactorsTwinsWakefulness

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

26799852

Citation

Ouellet-Morin, Isabelle, et al. "Evidence of a Unique and Common Genetic Etiology Between the CAR and the Remaining Part of the Diurnal Cycle: a Study of 14 Year-old Twins." Psychoneuroendocrinology, vol. 66, 2016, pp. 91-100.
Ouellet-Morin I, Brendgen M, Girard A, et al. Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins. Psychoneuroendocrinology. 2016;66:91-100.
Ouellet-Morin, I., Brendgen, M., Girard, A., Lupien, S. J., Dionne, G., Vitaro, F., & Boivin, M. (2016). Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins. Psychoneuroendocrinology, 66, 91-100. https://doi.org/10.1016/j.psyneuen.2015.12.022
Ouellet-Morin I, et al. Evidence of a Unique and Common Genetic Etiology Between the CAR and the Remaining Part of the Diurnal Cycle: a Study of 14 Year-old Twins. Psychoneuroendocrinology. 2016;66:91-100. PubMed PMID: 26799852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of a unique and common genetic etiology between the CAR and the remaining part of the diurnal cycle: A study of 14 year-old twins. AU - Ouellet-Morin,Isabelle, AU - Brendgen,Mara, AU - Girard,Alain, AU - Lupien,Sonia J, AU - Dionne,Ginette, AU - Vitaro,Frank, AU - Boivin,Michel, Y1 - 2016/01/08/ PY - 2015/09/22/received PY - 2015/12/10/revised PY - 2015/12/17/accepted PY - 2016/1/23/entrez PY - 2016/1/23/pubmed PY - 2016/12/24/medline KW - Cortisol KW - Cortisol awakening response KW - Diurnal rhythm KW - Genes KW - HPA axis KW - Twin studies SP - 91 EP - 100 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 66 N2 - INTRODUCTION: By and large, studies have reported moderate contributions of genetic factors to cortisol secreted in the early morning and even smaller estimates later in the day. In contrast, the cortisol awakening response (CAR) has shown much stronger heritability estimates, which prompted the hypothesis that the etiology of cortisol secretion may vary according to the time of day. A direct test of this possibility has, however, not yet been performed. OBJECTIVE: To describe the specific and common etiology of the CAR, awakening level and cortisol change from morning to evening in an age-homogenous sample of twin adolescents. METHODS: A total of 592 participants of the Québec Newborn Twin Study, a population-based 1995-1998 cohort of families with twins in Canada, have collected saliva at awakening, 30 min later, at the end of afternoon and in the evening over four collection days. RESULTS: Multivariate Cholesky models showed both specific and common sources of variance between the CAR, awakening and cortisol diurnal change. The CAR had the strongest heritability estimates, which, for the most part, did not overlap with the other indicators. Conversely, similar magnitudes of genetic and environmental contributions were detected at awakening and for diurnal change, which partially overlapped. CONCLUSION: Our study unraveled differences between the latent etiologies of the CAR and the rest of the diurnal cycle, which may contribute to identify regulatory genes and environments and detangle how these indicators each relate to physical and mental health. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/26799852/Evidence_of_a_unique_and_common_genetic_etiology_between_the_CAR_and_the_remaining_part_of_the_diurnal_cycle:_A_study_of_14_year_old_twins_ DB - PRIME DP - Unbound Medicine ER -