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Mixture toxicity and interactions of copper, nickel, cadmium, and zinc to barley at low effect levels: Something from nothing?
Environ Toxicol Chem. 2016 10; 35(10):2483-2492.ET

Abstract

Metal contamination is mostly a mixture of different metals, and these multicomponent mixtures can produce significant mixture effects. The present study was set up to investigate the toxicity of multiple metal mixtures of Cu, Ni, Cd, and Zn to plants at metal doses individually causing low-level phytotoxic effects. Barley (Hordeum vulgare L.) root elongation toxicity tests were performed in resin-buffered nutrient solutions to control metal speciation. Treatments included single-metal concentrations and binary, ternary, and quaternary mixtures. Mixtures of different metals at free ion concentrations, each causing <10% inhibition of root elongation, yielded significant mixture effects, with inhibition reaching up to 50%. The independent action (IA) model predicted mixture toxicity statistically better than the concentration addition (CA) model, but some synergisms relative to the IA model were observed. These synergisms relative to IA were most pronounced in quaternary mixtures and when the dose-response curves had steep slopes. Generally, antagonistic interactions relative to the CA model were observed. Increasing solution Zn concentrations shifted metal interactions (CA based) from additive or slightly synergistic at background Zn concentrations to antagonistic at higher Zn concentrations, suggesting a protective effect of Zn. Overall, the present study shows that the CA model can be used as a conservative model to predict metal mixture toxicity to barley. Environ Toxicol Chem 2016;35:2483-2492. © 2016 SETAC.

Authors+Show Affiliations

Division of Soil and Water Management, KU Leuven, Leuven, Belgium. liske.versieren@ees.kuleuven.be.Division of Soil and Water Management, KU Leuven, Leuven, Belgium.Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Ghent, Belgium.Department of Biology (SPHERE Group), University of Antwerp, Antwerp, Belgium.Division of Soil and Water Management, KU Leuven, Leuven, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26800646

Citation

Versieren, Liske, et al. "Mixture Toxicity and Interactions of Copper, Nickel, Cadmium, and Zinc to Barley at Low Effect Levels: Something From Nothing?" Environmental Toxicology and Chemistry, vol. 35, no. 10, 2016, pp. 2483-2492.
Versieren L, Evers S, De Schamphelaere K, et al. Mixture toxicity and interactions of copper, nickel, cadmium, and zinc to barley at low effect levels: Something from nothing? Environ Toxicol Chem. 2016;35(10):2483-2492.
Versieren, L., Evers, S., De Schamphelaere, K., Blust, R., & Smolders, E. (2016). Mixture toxicity and interactions of copper, nickel, cadmium, and zinc to barley at low effect levels: Something from nothing? Environmental Toxicology and Chemistry, 35(10), 2483-2492. https://doi.org/10.1002/etc.3380
Versieren L, et al. Mixture Toxicity and Interactions of Copper, Nickel, Cadmium, and Zinc to Barley at Low Effect Levels: Something From Nothing. Environ Toxicol Chem. 2016;35(10):2483-2492. PubMed PMID: 26800646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mixture toxicity and interactions of copper, nickel, cadmium, and zinc to barley at low effect levels: Something from nothing? AU - Versieren,Liske, AU - Evers,Steffie, AU - De Schamphelaere,Karel, AU - Blust,Ronny, AU - Smolders,Erik, Y1 - 2016/05/16/ PY - 2015/11/18/received PY - 2016/01/04/revised PY - 2016/01/22/accepted PY - 2016/1/24/pubmed PY - 2017/7/4/medline PY - 2016/1/24/entrez KW - Antagonism KW - Metals KW - Mixture toxicity KW - Root elongation KW - Synergism SP - 2483 EP - 2492 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 35 IS - 10 N2 - Metal contamination is mostly a mixture of different metals, and these multicomponent mixtures can produce significant mixture effects. The present study was set up to investigate the toxicity of multiple metal mixtures of Cu, Ni, Cd, and Zn to plants at metal doses individually causing low-level phytotoxic effects. Barley (Hordeum vulgare L.) root elongation toxicity tests were performed in resin-buffered nutrient solutions to control metal speciation. Treatments included single-metal concentrations and binary, ternary, and quaternary mixtures. Mixtures of different metals at free ion concentrations, each causing <10% inhibition of root elongation, yielded significant mixture effects, with inhibition reaching up to 50%. The independent action (IA) model predicted mixture toxicity statistically better than the concentration addition (CA) model, but some synergisms relative to the IA model were observed. These synergisms relative to IA were most pronounced in quaternary mixtures and when the dose-response curves had steep slopes. Generally, antagonistic interactions relative to the CA model were observed. Increasing solution Zn concentrations shifted metal interactions (CA based) from additive or slightly synergistic at background Zn concentrations to antagonistic at higher Zn concentrations, suggesting a protective effect of Zn. Overall, the present study shows that the CA model can be used as a conservative model to predict metal mixture toxicity to barley. Environ Toxicol Chem 2016;35:2483-2492. © 2016 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/26800646/Mixture_toxicity_and_interactions_of_copper_nickel_cadmium_and_zinc_to_barley_at_low_effect_levels:_Something_from_nothing DB - PRIME DP - Unbound Medicine ER -