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Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex.
Behav Brain Res. 2016 Apr 01; 302:191-9.BB

Abstract

Depression is one of the most common neuropsychiatric disorders and has been associated with oxidative stress and brain protein alterations. Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities including potent antidepressant-like effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring oxidative stress parameters and phosphorylation of AKT/mTOR pathway in the rat hippocampus and prefrontal cortex (PFC) exposed to the chronic unpredictable mild stress (CUMS). Male Wistar rats were subjected to CUMS protocol for a period of 4 weeks to induce depressive-like behavior. The results showed that resveratrol treatment (80 mg/kg/i.p. 4 weeks) significantly reversed the CUMS-induced behavioral abnormalities (reduced sucrose preference, increased immobility time and decreased locomotor activity) and biochemical changes (increased lipid peroxidation and decreased superoxide dismutase). Additionally, CUMS exposure significantly decreased phosphorylation of Akt and mTOR in the hippocampus and PFC, while resveratrol treatment normalized these parameters. In conclusion, our study showed that resveratrol exerted antidepressant-like effects in CUMS rats, which was mediated in part by its antioxidant action, up-regulation of phosphor-Akt and mTOR levels in the hippocampus and PFC.

Authors+Show Affiliations

Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China; Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, 107#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: liudexiang@sdu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26801825

Citation

liu, Song, et al. "Resveratrol Exerts Antidepressant Properties in the Chronic Unpredictable Mild Stress Model Through the Regulation of Oxidative Stress and mTOR Pathway in the Rat Hippocampus and Prefrontal Cortex." Behavioural Brain Research, vol. 302, 2016, pp. 191-9.
liu S, Li T, Liu H, et al. Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Behav Brain Res. 2016;302:191-9.
liu, S., Li, T., Liu, H., Wang, X., Bo, S., Xie, Y., Bai, X., Wu, L., Wang, Z., & Liu, D. (2016). Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. Behavioural Brain Research, 302, 191-9. https://doi.org/10.1016/j.bbr.2016.01.037
liu S, et al. Resveratrol Exerts Antidepressant Properties in the Chronic Unpredictable Mild Stress Model Through the Regulation of Oxidative Stress and mTOR Pathway in the Rat Hippocampus and Prefrontal Cortex. Behav Brain Res. 2016 Apr 1;302:191-9. PubMed PMID: 26801825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex. AU - liu,Song, AU - Li,Tong, AU - Liu,Hansen, AU - Wang,Xueer, AU - Bo,Shishi, AU - Xie,Yunkai, AU - Bai,Xuemei, AU - Wu,Lin, AU - Wang,Zhen, AU - Liu,Dexiang, Y1 - 2016/01/19/ PY - 2015/09/02/received PY - 2016/01/13/revised PY - 2016/01/16/accepted PY - 2016/1/24/entrez PY - 2016/1/24/pubmed PY - 2016/12/15/medline KW - Akt KW - Chronic unpredictable mild stress (CUMS) KW - Depression KW - Resveratrol KW - mTOR SP - 191 EP - 9 JF - Behavioural brain research JO - Behav. Brain Res. VL - 302 N2 - Depression is one of the most common neuropsychiatric disorders and has been associated with oxidative stress and brain protein alterations. Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities including potent antidepressant-like effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring oxidative stress parameters and phosphorylation of AKT/mTOR pathway in the rat hippocampus and prefrontal cortex (PFC) exposed to the chronic unpredictable mild stress (CUMS). Male Wistar rats were subjected to CUMS protocol for a period of 4 weeks to induce depressive-like behavior. The results showed that resveratrol treatment (80 mg/kg/i.p. 4 weeks) significantly reversed the CUMS-induced behavioral abnormalities (reduced sucrose preference, increased immobility time and decreased locomotor activity) and biochemical changes (increased lipid peroxidation and decreased superoxide dismutase). Additionally, CUMS exposure significantly decreased phosphorylation of Akt and mTOR in the hippocampus and PFC, while resveratrol treatment normalized these parameters. In conclusion, our study showed that resveratrol exerted antidepressant-like effects in CUMS rats, which was mediated in part by its antioxidant action, up-regulation of phosphor-Akt and mTOR levels in the hippocampus and PFC. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/26801825/Resveratrol_exerts_antidepressant_properties_in_the_chronic_unpredictable_mild_stress_model_through_the_regulation_of_oxidative_stress_and_mTOR_pathway_in_the_rat_hippocampus_and_prefrontal_cortex_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(16)30033-X DB - PRIME DP - Unbound Medicine ER -