Tags

Type your tag names separated by a space and hit enter

Effect of cisapride on postprandial gastro-oesophageal reflux.
Gut 1989; 30(9):1187-93Gut

Abstract

We studied the effect of cisapride on oesophageal motor function and postprandial gastro-oesophageal reflux in a randomised, double blind, placebo controlled crossover study. In 16 patients with symptomatic gastro-oesophageal reflux, cisapride 10 mg orally and placebo were studied on separate days according to identical protocols. Cisapride and placebo were given 30 minutes before a standard meal. Each study day was preceded by corresponding three day oral loading of cisapride (10 mg tds) or placebo. Lower oesophageal sphincter pressure, oesophageal body motility and oesophageal pH were monitored for 30 minutes before and three hours after the meal. Plasma cisapride concentrations were measured before and after dosing on both study days. With cisapride treatment, the plasma cisapride levels ranged from 48.1 (5.0) to 75.9 (6.9) ng/ml. Plasma levels were undetectable during placebo treatment. Cisapride enhanced acid clearance but had no significant effect on the duration of acid exposure, the rate of reflux episodes, the pattern of lower oesophageal sphincter pressure associated with the reflux episodes, basal lower oesophageal sphincter pressure or oesophageal peristalsis. These findings do not suggest a major role for cisapride, at the dosage tested, for the control of troublesome postprandial gastro-oesophageal reflux.

Authors+Show Affiliations

Department of Medicine, Flinders Medical Centre, Bedford Park, South Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2680794

Citation

Holloway, R H., et al. "Effect of Cisapride On Postprandial Gastro-oesophageal Reflux." Gut, vol. 30, no. 9, 1989, pp. 1187-93.
Holloway RH, Downton J, Mitchell B, et al. Effect of cisapride on postprandial gastro-oesophageal reflux. Gut. 1989;30(9):1187-93.
Holloway, R. H., Downton, J., Mitchell, B., & Dent, J. (1989). Effect of cisapride on postprandial gastro-oesophageal reflux. Gut, 30(9), pp. 1187-93.
Holloway RH, et al. Effect of Cisapride On Postprandial Gastro-oesophageal Reflux. Gut. 1989;30(9):1187-93. PubMed PMID: 2680794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cisapride on postprandial gastro-oesophageal reflux. AU - Holloway,R H, AU - Downton,J, AU - Mitchell,B, AU - Dent,J, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 1187 EP - 93 JF - Gut JO - Gut VL - 30 IS - 9 N2 - We studied the effect of cisapride on oesophageal motor function and postprandial gastro-oesophageal reflux in a randomised, double blind, placebo controlled crossover study. In 16 patients with symptomatic gastro-oesophageal reflux, cisapride 10 mg orally and placebo were studied on separate days according to identical protocols. Cisapride and placebo were given 30 minutes before a standard meal. Each study day was preceded by corresponding three day oral loading of cisapride (10 mg tds) or placebo. Lower oesophageal sphincter pressure, oesophageal body motility and oesophageal pH were monitored for 30 minutes before and three hours after the meal. Plasma cisapride concentrations were measured before and after dosing on both study days. With cisapride treatment, the plasma cisapride levels ranged from 48.1 (5.0) to 75.9 (6.9) ng/ml. Plasma levels were undetectable during placebo treatment. Cisapride enhanced acid clearance but had no significant effect on the duration of acid exposure, the rate of reflux episodes, the pattern of lower oesophageal sphincter pressure associated with the reflux episodes, basal lower oesophageal sphincter pressure or oesophageal peristalsis. These findings do not suggest a major role for cisapride, at the dosage tested, for the control of troublesome postprandial gastro-oesophageal reflux. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/2680794/Effect_of_cisapride_on_postprandial_gastro_oesophageal_reflux_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=2680794 DB - PRIME DP - Unbound Medicine ER -