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Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.
Exp Gerontol 2016; 76:33-8EG

Abstract

BACKGROUND

Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive.

OBJECTIVE

The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations.

METHODS

Men and women aged 45-69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006-2008. Serum concentrations of biomarkers at baseline were measured in a sub-sample of participants. Associations of vitamin quartiles with baseline (n=4166) and follow-up (n=2739) cognitive domain-specific z-scores were estimated using multiple linear regression.

RESULTS

After adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word recall in cross-sectional analyses. In prospective analyses, participants in the highest quartile of folate had higher verbal fluency (p<0.01) and immediate recall (p<0.05) scores compared to those in the bottom quartile. In addition, participants in the highest quartile of vitamin B-12 had significantly higher verbal fluency scores (β=0.12; 95% CI=0.02, 0.21).

CONCLUSIONS

Folate and vitamin B-12 were positively associated with performance in some but not all cognitive domains in older Central and Eastern Europeans. These findings do not lend unequivocal support to potential importance of folate and vitamin B-12 status for cognitive function in older age. Long-term longitudinal studies and randomised trials are required before drawing conclusions on the role of these vitamins in cognitive decline.

Authors+Show Affiliations

Department of Epidemiology & Public Health, UCL, 1-19 Torrington Place, London WC1E 7HB, UK. Electronic address: pia.horvat.10@ucl.ac.uk.Department of Education, University of Oxford, 15 Norham Gardens, Oxford OX2 6PY, UK.National Institute of Public Health, Srobarova 48, 10042 Prague, Czech Republic.Department of Epidemiology and Population Studies, Jagellonian University Collegium Medicum, Grzegorzecka 20, 31-531 Krakow, Poland.Department of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.Department of Epidemiology & Public Health, UCL, 1-19 Torrington Place, London WC1E 7HB, UK.Department of Epidemiology & Public Health, UCL, 1-19 Torrington Place, London WC1E 7HB, UK.Center for Health Protection, National Institute for Public Health and the Environment, PO Box 1, 3720 BA, Bilthoven, The Netherlands.Department of Epidemiology & Public Health, UCL, 1-19 Torrington Place, London WC1E 7HB, UK.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26808046

Citation

Horvat, Pia, et al. "Serum Folate, Vitamin B-12 and Cognitive Function in Middle and Older Age: the HAPIEE Study." Experimental Gerontology, vol. 76, 2016, pp. 33-8.
Horvat P, Gardiner J, Kubinova R, et al. Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study. Exp Gerontol. 2016;76:33-8.
Horvat, P., Gardiner, J., Kubinova, R., Pajak, A., Tamosiunas, A., Schöttker, B., ... Bobak, M. (2016). Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study. Experimental Gerontology, 76, pp. 33-8. doi:10.1016/j.exger.2016.01.011.
Horvat P, et al. Serum Folate, Vitamin B-12 and Cognitive Function in Middle and Older Age: the HAPIEE Study. Exp Gerontol. 2016;76:33-8. PubMed PMID: 26808046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study. AU - Horvat,Pia, AU - Gardiner,Julian, AU - Kubinova,Ruzena, AU - Pajak,Andrzej, AU - Tamosiunas,Abdonas, AU - Schöttker,Ben, AU - Pikhart,Hynek, AU - Peasey,Anne, AU - Jansen,Eugene, AU - Bobak,Martin, Y1 - 2016/01/22/ PY - 2015/08/03/received PY - 2016/01/20/revised PY - 2016/01/21/accepted PY - 2016/1/26/entrez PY - 2016/1/26/pubmed PY - 2016/12/15/medline KW - Ageing KW - Biomarkers KW - Cognitive function KW - Eastern Europe KW - Folate KW - Vitamin B-12 SP - 33 EP - 8 JF - Experimental gerontology JO - Exp. Gerontol. VL - 76 N2 - BACKGROUND: Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive. OBJECTIVE: The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations. METHODS: Men and women aged 45-69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006-2008. Serum concentrations of biomarkers at baseline were measured in a sub-sample of participants. Associations of vitamin quartiles with baseline (n=4166) and follow-up (n=2739) cognitive domain-specific z-scores were estimated using multiple linear regression. RESULTS: After adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word recall in cross-sectional analyses. In prospective analyses, participants in the highest quartile of folate had higher verbal fluency (p<0.01) and immediate recall (p<0.05) scores compared to those in the bottom quartile. In addition, participants in the highest quartile of vitamin B-12 had significantly higher verbal fluency scores (β=0.12; 95% CI=0.02, 0.21). CONCLUSIONS: Folate and vitamin B-12 were positively associated with performance in some but not all cognitive domains in older Central and Eastern Europeans. These findings do not lend unequivocal support to potential importance of folate and vitamin B-12 status for cognitive function in older age. Long-term longitudinal studies and randomised trials are required before drawing conclusions on the role of these vitamins in cognitive decline. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/26808046/Serum_folate_vitamin_B_12_and_cognitive_function_in_middle_and_older_age:_The_HAPIEE_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(16)30011-0 DB - PRIME DP - Unbound Medicine ER -