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An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans.
J Agric Food Chem 2016; 64(6):1283-90JA

Abstract

Acai fruits (Euterpe precatoria) are rich in antioxidant anthocyanins. Acai consumption is believed to have many health benefits; however, relevant detailed scientific investigations are limited. The current study aimed to investigate an anthocyanin-rich extract from E. precatoria fruits (AE) with regard to its antioxidant and antiaging properties using the model organism Caenorhabditis elegans. AE can protect the worms against oxidative stress and can ameliorate accumulation of reactive oxygen species in vivo. The expression of stress-response genes, such as sod-3::GFP, was upregulated while hsp-16::GFP was down-regulated after AE treatment. Studies with DAF-16/FOXO mutants indicated that some of the antioxidant effects are mediated by this transcription factor. AE can modulate the development of age-related markers, such as pharyngeal pumping. Despite the apparent antioxidant activity, no lifespan-prolonging effect was observed.

Authors+Show Affiliations

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern , Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany.Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern , Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany.Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26809379

Citation

Peixoto, Herbenya, et al. "An Anthocyanin-Rich Extract of Acai (Euterpe Precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis Elegans." Journal of Agricultural and Food Chemistry, vol. 64, no. 6, 2016, pp. 1283-90.
Peixoto H, Roxo M, Krstin S, et al. An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans. J Agric Food Chem. 2016;64(6):1283-90.
Peixoto, H., Roxo, M., Krstin, S., Röhrig, T., Richling, E., & Wink, M. (2016). An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 64(6), pp. 1283-90. doi:10.1021/acs.jafc.5b05812.
Peixoto H, et al. An Anthocyanin-Rich Extract of Acai (Euterpe Precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis Elegans. J Agric Food Chem. 2016 Feb 17;64(6):1283-90. PubMed PMID: 26809379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans. AU - Peixoto,Herbenya, AU - Roxo,Mariana, AU - Krstin,Sonja, AU - Röhrig,Teresa, AU - Richling,Elke, AU - Wink,Michael, Y1 - 2016/02/03/ PY - 2016/1/27/entrez PY - 2016/1/27/pubmed PY - 2016/10/8/medline KW - Caenorhabditis elegans KW - acai KW - aging KW - anthocyanins KW - antioxidants KW - oxidative stress SP - 1283 EP - 90 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 64 IS - 6 N2 - Acai fruits (Euterpe precatoria) are rich in antioxidant anthocyanins. Acai consumption is believed to have many health benefits; however, relevant detailed scientific investigations are limited. The current study aimed to investigate an anthocyanin-rich extract from E. precatoria fruits (AE) with regard to its antioxidant and antiaging properties using the model organism Caenorhabditis elegans. AE can protect the worms against oxidative stress and can ameliorate accumulation of reactive oxygen species in vivo. The expression of stress-response genes, such as sod-3::GFP, was upregulated while hsp-16::GFP was down-regulated after AE treatment. Studies with DAF-16/FOXO mutants indicated that some of the antioxidant effects are mediated by this transcription factor. AE can modulate the development of age-related markers, such as pharyngeal pumping. Despite the apparent antioxidant activity, no lifespan-prolonging effect was observed. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/26809379/An_Anthocyanin_Rich_Extract_of_Acai__Euterpe_precatoria_Mart___Increases_Stress_Resistance_and_Retards_Aging_Related_Markers_in_Caenorhabditis_elegans_ L2 - https://dx.doi.org/10.1021/acs.jafc.5b05812 DB - PRIME DP - Unbound Medicine ER -