Tags

Type your tag names separated by a space and hit enter

Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses.
J Neurol Sci. 2016 Feb 15; 361:243-9.JN

Abstract

Laryngeal stridor is recognized as a characteristic clinical manifestation in patients with multiple system atrophy (MSA). However, the pathogenic mechanisms underlying this symptom are controversial. Neurogenic atrophy of the posterior cricoarytenoid muscle has been identified in cases of MSA, suggesting that laryngeal abductor weakness contributes to laryngeal stridor. However, dystonia in the laryngeal adductor muscles has also been reported to cause laryngeal stridor. Depletion of serotonergic neurons in the medullary raphe nuclei, which exert tonic drive to activate the posterior cricoarytenoid muscle, has recently been identified in MSA cases. This adds weight to the possibility that laryngeal abductor weakness underlies laryngeal stridor in MSA. Continuous positive airway pressure therapy is currently used in the treatment of laryngeal stridor, but should be used with caution in patients showing contraindications. Current knowledge of the clinical and neuropathological features of laryngeal stridor is summarized in this paper, and the hypothesized causes and possible therapeutic options for this symptom are discussed.

Authors+Show Affiliations

Department of Neurology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minami Uonuma, Niigata 949-7302, Japan. Electronic address: ozawa@bri.niigata-u.ac.jp.Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi-dori Chuoku, Niigata 951-8585, Japan.Department of Otorhinolaryngology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minami Uonuma, Niigata 949-7302, Japan.Department of Medical Informatics, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minami Uonuma, Niigata 949-7302, Japan.Department of Neurology, Brain Research Institute, Niigata University, 1 Asahimachi-dori Chuoku, Niigata 951-8585, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26810550

Citation

Ozawa, Tetsutaro, et al. "Laryngeal Stridor in Multiple System Atrophy: Clinicopathological Features and Causal Hypotheses." Journal of the Neurological Sciences, vol. 361, 2016, pp. 243-9.
Ozawa T, Sekiya K, Aizawa N, et al. Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses. J Neurol Sci. 2016;361:243-9.
Ozawa, T., Sekiya, K., Aizawa, N., Terajima, K., & Nishizawa, M. (2016). Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses. Journal of the Neurological Sciences, 361, 243-9. https://doi.org/10.1016/j.jns.2016.01.007
Ozawa T, et al. Laryngeal Stridor in Multiple System Atrophy: Clinicopathological Features and Causal Hypotheses. J Neurol Sci. 2016 Feb 15;361:243-9. PubMed PMID: 26810550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses. AU - Ozawa,Tetsutaro, AU - Sekiya,Kanako, AU - Aizawa,Naotaka, AU - Terajima,Kenshi, AU - Nishizawa,Masatoyo, Y1 - 2016/01/07/ PY - 2015/09/03/received PY - 2015/12/28/revised PY - 2016/01/04/accepted PY - 2016/1/27/entrez PY - 2016/1/27/pubmed PY - 2016/10/21/medline KW - Autonomic dysfunction KW - Laryngeal stridor KW - Multiple system atrophy KW - Sleep-related breathing disorders KW - Sudden death SP - 243 EP - 9 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 361 N2 - Laryngeal stridor is recognized as a characteristic clinical manifestation in patients with multiple system atrophy (MSA). However, the pathogenic mechanisms underlying this symptom are controversial. Neurogenic atrophy of the posterior cricoarytenoid muscle has been identified in cases of MSA, suggesting that laryngeal abductor weakness contributes to laryngeal stridor. However, dystonia in the laryngeal adductor muscles has also been reported to cause laryngeal stridor. Depletion of serotonergic neurons in the medullary raphe nuclei, which exert tonic drive to activate the posterior cricoarytenoid muscle, has recently been identified in MSA cases. This adds weight to the possibility that laryngeal abductor weakness underlies laryngeal stridor in MSA. Continuous positive airway pressure therapy is currently used in the treatment of laryngeal stridor, but should be used with caution in patients showing contraindications. Current knowledge of the clinical and neuropathological features of laryngeal stridor is summarized in this paper, and the hypothesized causes and possible therapeutic options for this symptom are discussed. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/26810550/Laryngeal_stridor_in_multiple_system_atrophy:_Clinicopathological_features_and_causal_hypotheses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30007-7 DB - PRIME DP - Unbound Medicine ER -