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Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice.
Int J Immunopathol Pharmacol. 2016 Jun; 29(2):205-16.IJ

Abstract

The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damage after the challenge with 100 mg/kg naphthalene. Hepatic malondialdehyde (MDA) contents and the activity of myeloperoxidase (MPO) increased significantly, accompanying a decrease in the hepatic activity of total superoxide dismutase (SOD) and glutathione (GSH) levels after the naphthalene damage. In addition, the serum levels of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 8 (IL-8) increased significantly in the groups damaged with naphthalene. The main parameters related to oxidative stress and inflammatory responses in the lungs, including the NO, MPO, and GSH contents, were determined, and the histopathological and immunohistochemical changes in the lung and liver tissues were also observed. In the DATS-treated groups, all of the oxidative and inflammatory damage in the serum, liver, and lung tissues were significantly prevented.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.School of Pharmaceutical Sciences, Shandong University, Jinan, PR China School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology, Jinan, Shandong, PR China.School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.School of Pharmaceutical Sciences, Shandong University, Jinan, PR China.School of Pharmaceutical Sciences, Shandong University, Jinan, PR China Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China uszxzhao@gmail.com.Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26813860

Citation

Zhang, Fang, et al. "Protective Effect of Diallyl Trisulfide Against Naphthalene-induced Oxidative Stress and Inflammatory Damage in Mice." International Journal of Immunopathology and Pharmacology, vol. 29, no. 2, 2016, pp. 205-16.
Zhang F, Zhang Y, Wang K, et al. Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice. Int J Immunopathol Pharmacol. 2016;29(2):205-16.
Zhang, F., Zhang, Y., Wang, K., Liu, G., Yang, M., Zhao, Z., Li, S., Cai, J., & Cao, J. (2016). Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice. International Journal of Immunopathology and Pharmacology, 29(2), 205-16. https://doi.org/10.1177/0394632015627160
Zhang F, et al. Protective Effect of Diallyl Trisulfide Against Naphthalene-induced Oxidative Stress and Inflammatory Damage in Mice. Int J Immunopathol Pharmacol. 2016;29(2):205-16. PubMed PMID: 26813860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice. AU - Zhang,Fang, AU - Zhang,Yongchun, AU - Wang,Kaiming, AU - Liu,Guangpu, AU - Yang,Min, AU - Zhao,Zhongxi, AU - Li,Shanzhong, AU - Cai,Jianhua, AU - Cao,Jimin, Y1 - 2016/01/26/ PY - 2015/06/16/received PY - 2015/12/01/accepted PY - 2016/1/28/entrez PY - 2016/1/28/pubmed PY - 2017/4/4/medline KW - diallyl trisulfide KW - inflammatory KW - myeloperoxidase KW - naphthalene KW - nitric oxide KW - oxidative SP - 205 EP - 16 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 29 IS - 2 N2 - The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damage after the challenge with 100 mg/kg naphthalene. Hepatic malondialdehyde (MDA) contents and the activity of myeloperoxidase (MPO) increased significantly, accompanying a decrease in the hepatic activity of total superoxide dismutase (SOD) and glutathione (GSH) levels after the naphthalene damage. In addition, the serum levels of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 8 (IL-8) increased significantly in the groups damaged with naphthalene. The main parameters related to oxidative stress and inflammatory responses in the lungs, including the NO, MPO, and GSH contents, were determined, and the histopathological and immunohistochemical changes in the lung and liver tissues were also observed. In the DATS-treated groups, all of the oxidative and inflammatory damage in the serum, liver, and lung tissues were significantly prevented. SN - 2058-7384 UR - https://www.unboundmedicine.com/medline/citation/26813860/Protective_effect_of_diallyl_trisulfide_against_naphthalene_induced_oxidative_stress_and_inflammatory_damage_in_mice_ L2 - http://journals.sagepub.com/doi/full/10.1177/0394632015627160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -