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Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study.
PLoS One. 2016; 11(1):e0147056.Plos

Abstract

BACKGROUND

Several epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk.

METHODS

Studies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model.

RESULTS

Two case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68-0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912-0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81-1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake).

CONCLUSIONS

This meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings.

Authors+Show Affiliations

Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.Nantong Tumor Hospital, Nantong Pingchao town, Tong yang Rd. 30, 226361, Jiangsu province, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

26816289

Citation

Liu, Jibin, et al. "Higher Caffeinated Coffee Intake Is Associated With Reduced Malignant Melanoma Risk: a Meta-Analysis Study." PloS One, vol. 11, no. 1, 2016, pp. e0147056.
Liu J, Shen B, Shi M, et al. Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study. PLoS One. 2016;11(1):e0147056.
Liu, J., Shen, B., Shi, M., & Cai, J. (2016). Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study. PloS One, 11(1), e0147056. https://doi.org/10.1371/journal.pone.0147056
Liu J, et al. Higher Caffeinated Coffee Intake Is Associated With Reduced Malignant Melanoma Risk: a Meta-Analysis Study. PLoS One. 2016;11(1):e0147056. PubMed PMID: 26816289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study. AU - Liu,Jibin, AU - Shen,Biao, AU - Shi,Minxin, AU - Cai,Jing, Y1 - 2016/01/27/ PY - 2015/09/23/received PY - 2015/12/28/accepted PY - 2016/1/28/entrez PY - 2016/1/28/pubmed PY - 2016/7/28/medline SP - e0147056 EP - e0147056 JF - PloS one JO - PLoS One VL - 11 IS - 1 N2 - BACKGROUND: Several epidemiological studies have determined the associations between coffee intake level and skin cancer risk; however, the results were not yet conclusive. Herein, we conducted a systematic review and meta-analysis of the cohort and case-control studies for the association between coffee intake level and malignant melanoma (MM) risk. METHODS: Studies were identified through searching the PubMed and MEDLINE databases (to November, 2015). Study-specific risk estimates were pooled under the random-effects model. RESULTS: Two case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases) were identified. For caffeinated coffee, the pooled relative risk (RR) of MM was 0.81 [95% confidential interval (95% CI) = 0.68-0.97; P-value for Q-test = 0.003; I2 = 63.5%] for those with highest versus lowest quantity of intake. In the dose-response analysis, the RR of MM was 0.955 (95% CI = 0.912-0.999) for per 1 cup/day increment of caffeinated coffee consumption and linearity dose-response association was found (P-value for nonlinearity = 0.326). Strikingly, no significant association was found between the decaffeinated coffee intake level and MM risk (pooled RR = 0.92, 95% CI = 0.81-1.05; P-value for Q-test = 0.967; I2 = 0%; highest versus lowest quantity of intake). CONCLUSIONS: This meta-analysis suggested that caffeinated coffee might have chemo-preventive effects against MM but not decaffeinated coffee. However, larger prospective studies and the intervention studies are warranted to confirm these findings. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26816289/Higher_Caffeinated_Coffee_Intake_Is_Associated_with_Reduced_Malignant_Melanoma_Risk:_A_Meta_Analysis_Study_ L2 - https://dx.plos.org/10.1371/journal.pone.0147056 DB - PRIME DP - Unbound Medicine ER -