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Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome.

Abstract

INTRODUCTION

The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS).

MATERIAL AND METHOD

95 patients gave their informed consent to participate in the study and were divided into 2 groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (7 am), fasting blood samples were taken for the assessment of luteinizng hormone (LH), follicle stimulating hormone (FSH), estradiol, cortisol, prolactin, thyreotropin (TSH), testosterone and dehydroepeiandrosterone (DHEAS). Evening (5 pm) blood samples were also taken for the evaluation of plasma cortisol level

RESULTS

There were no differences in mean age, body mass index (BMI), FSH, SHBG, PRL, estradiol and TSH levels between group A and group B. Mean plasma LH level was higher in group A compared to group B (10.7 ± 6.8 IU/l vs 6.6 ± 4.5 LU/l, p < 0.02). Mean plasma testosterone and DHEAS levels were also higher in PCOS patients (3.8 ± 0.6 nmol/l vs 1.63 ± 0.6 nmol/l; 427.7 ± 162.9 vs 236.6 ± 97.8 respectively, p < 0.001). Mean evening plasma cortisol level was higher in PCOS patients (11.8 ± 4.1 ug/dl vs 4.7 ± 1.3 ug/dl, p < 0.02). Mean morning plasma cortisol levels did not differ between groups.

CONCLUSION

PCOS women showed the increased evening plasma cortisol level with impacted diurnal secretion rate.

Authors

, , , , , , ,

Source

Przeglad lekarski 72:5 2015 pg 240-2

MeSH

Adult
Body Mass Index
Circadian Rhythm
Estradiol
Female
Follicle Stimulating Hormone
Humans
Hydrocortisone
Luteinizing Hormone
Polycystic Ovary Syndrome
Prolactin
Testosterone
Thyrotropin
Young Adult

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

26817325

Citation

Kiałka, Marta, et al. "Evening Not Morning Plasma Cortisol Level Is Higher in Women With Polycystic Ovary Syndrome." Przeglad Lekarski, vol. 72, no. 5, 2015, pp. 240-2.
Kiałka M, Ociepka A, Milewicz T, et al. Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome. Prz Lek. 2015;72(5):240-2.
Kiałka, M., Ociepka, A., Milewicz, T., Krzyczkowska-Sendrakowska, M., Gosztyła, K., Stochmal, E., ... Bałajewicz-Nowak, M. (2015). Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome. Przeglad Lekarski, 72(5), pp. 240-2.
Kiałka M, et al. Evening Not Morning Plasma Cortisol Level Is Higher in Women With Polycystic Ovary Syndrome. Prz Lek. 2015;72(5):240-2. PubMed PMID: 26817325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evening not morning plasma cortisol level is higher in women with polycystic ovary syndrome. AU - Kiałka,Marta, AU - Ociepka,Agnieszka, AU - Milewicz,Tomasz, AU - Krzyczkowska-Sendrakowska,Magdalena, AU - Gosztyła,Katarzyna, AU - Stochmal,Ewa, AU - Lurzyńska,Małgorzata, AU - Bałajewicz-Nowak,Marta, PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/2/19/medline SP - 240 EP - 2 JF - Przeglad lekarski JO - Prz. Lek. VL - 72 IS - 5 N2 - INTRODUCTION: The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS). MATERIAL AND METHOD: 95 patients gave their informed consent to participate in the study and were divided into 2 groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (7 am), fasting blood samples were taken for the assessment of luteinizng hormone (LH), follicle stimulating hormone (FSH), estradiol, cortisol, prolactin, thyreotropin (TSH), testosterone and dehydroepeiandrosterone (DHEAS). Evening (5 pm) blood samples were also taken for the evaluation of plasma cortisol level RESULTS: There were no differences in mean age, body mass index (BMI), FSH, SHBG, PRL, estradiol and TSH levels between group A and group B. Mean plasma LH level was higher in group A compared to group B (10.7 ± 6.8 IU/l vs 6.6 ± 4.5 LU/l, p < 0.02). Mean plasma testosterone and DHEAS levels were also higher in PCOS patients (3.8 ± 0.6 nmol/l vs 1.63 ± 0.6 nmol/l; 427.7 ± 162.9 vs 236.6 ± 97.8 respectively, p < 0.001). Mean evening plasma cortisol level was higher in PCOS patients (11.8 ± 4.1 ug/dl vs 4.7 ± 1.3 ug/dl, p < 0.02). Mean morning plasma cortisol levels did not differ between groups. CONCLUSION: PCOS women showed the increased evening plasma cortisol level with impacted diurnal secretion rate. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/26817325/Evening_not_morning_plasma_cortisol_level_is_higher_in_women_with_polycystic_ovary_syndrome_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -