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Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial.
Am J Clin Nutr. 2016 Mar; 103(3):942-51.AJ

Abstract

BACKGROUND

Zinc is essential for the regulation of immune response. T cell function declines with age. Zinc supplementation has the potential to improve the serum zinc concentrations and immunity of nursing home elderly with a low serum zinc concentration.

OBJECTIVE

We aimed to determine the effect of supplementation with 30 mg Zn/d for 3 mo on serum zinc concentrations of zinc-deficient nursing home elderly.

DESIGN

This was a randomized, double-blind, placebo-controlled study. Of 53 nursing home elderly (aged ≥65 y) who met eligibility criteria, 58% had a low serum zinc concentration (serum zinc <70 μg/dL); these 31 were randomly assigned to zinc (30 mg Zn/d) (n = 16) or placebo (5 mg Zn/d) (n = 15) groups. The primary outcome measure was change in serum zinc concentrations between baseline and month 3. We also explored the effects of supplementation on immune response.

RESULTS

Baseline characteristics were similar in the 2 groups. The difference in the mean change in serum zinc was significantly higher, by 16%, in the zinc group than in the placebo group (P = 0.007) when baseline zinc concentrations were controlled for. In addition, controlling for baseline C-reactive protein, copper, or albumin did not change the results. However, supplementation of participants with ≤60 μg serum Zn/dL failed to increase their serum zinc to ≥70 μg/dL. Zinc supplementation also significantly increased anti-CD3/CD28 and phytohemagglutinin-stimulated T cell proliferation, and the number of peripheral T cells (P < 0.05). When proliferation was expressed per number of T cells, the significant differences between groups were lost, suggesting that the zinc-induced enhancement of T cell proliferation was mainly due to an increase in the number of T cells.

CONCLUSIONS

Zinc supplementation at 30 mg/d for 3 mo is effective in increasing serum zinc concentrations in nursing home elderly; however, not all zinc-deficient elderly reached adequate concentrations. The increase in serum zinc concentration was associated with the enhancement of T cell function mainly because of an increase in the number of T cells.

Authors+Show Affiliations

Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; Section of Infectious Diseases and Center for Global Health and Development and Department of Global Health, Boston University School of Public Health, Boston, MA;Hebrew SeniorLife, Roslindale, MA; and Harvard Medical School, Boston, MA.Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Hebrew SeniorLife, Roslindale, MA; and Harvard Medical School, Boston, MA.Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA;Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; simin.meydani@tufts.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26817502

Citation

Barnett, Junaidah B., et al. "Effect of Zinc Supplementation On Serum Zinc Concentration and T Cell Proliferation in Nursing Home Elderly: a Randomized, Double-blind, Placebo-controlled Trial." The American Journal of Clinical Nutrition, vol. 103, no. 3, 2016, pp. 942-51.
Barnett JB, Dao MC, Hamer DH, et al. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2016;103(3):942-51.
Barnett, J. B., Dao, M. C., Hamer, D. H., Kandel, R., Brandeis, G., Wu, D., Dallal, G. E., Jacques, P. F., Schreiber, R., Kong, E., & Meydani, S. N. (2016). Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition, 103(3), 942-51. https://doi.org/10.3945/ajcn.115.115188
Barnett JB, et al. Effect of Zinc Supplementation On Serum Zinc Concentration and T Cell Proliferation in Nursing Home Elderly: a Randomized, Double-blind, Placebo-controlled Trial. Am J Clin Nutr. 2016;103(3):942-51. PubMed PMID: 26817502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. AU - Barnett,Junaidah B, AU - Dao,Maria C, AU - Hamer,Davidson H, AU - Kandel,Ruth, AU - Brandeis,Gary, AU - Wu,Dayong, AU - Dallal,Gerard E, AU - Jacques,Paul F, AU - Schreiber,Robert, AU - Kong,Eunhee, AU - Meydani,Simin N, Y1 - 2016/01/27/ PY - 2015/05/12/received PY - 2015/12/15/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/7/9/medline KW - T cell proliferation KW - nursing home elderly KW - serum zinc concentration KW - zinc gluconate KW - zinc supplementation SP - 942 EP - 51 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 103 IS - 3 N2 - BACKGROUND: Zinc is essential for the regulation of immune response. T cell function declines with age. Zinc supplementation has the potential to improve the serum zinc concentrations and immunity of nursing home elderly with a low serum zinc concentration. OBJECTIVE: We aimed to determine the effect of supplementation with 30 mg Zn/d for 3 mo on serum zinc concentrations of zinc-deficient nursing home elderly. DESIGN: This was a randomized, double-blind, placebo-controlled study. Of 53 nursing home elderly (aged ≥65 y) who met eligibility criteria, 58% had a low serum zinc concentration (serum zinc <70 μg/dL); these 31 were randomly assigned to zinc (30 mg Zn/d) (n = 16) or placebo (5 mg Zn/d) (n = 15) groups. The primary outcome measure was change in serum zinc concentrations between baseline and month 3. We also explored the effects of supplementation on immune response. RESULTS: Baseline characteristics were similar in the 2 groups. The difference in the mean change in serum zinc was significantly higher, by 16%, in the zinc group than in the placebo group (P = 0.007) when baseline zinc concentrations were controlled for. In addition, controlling for baseline C-reactive protein, copper, or albumin did not change the results. However, supplementation of participants with ≤60 μg serum Zn/dL failed to increase their serum zinc to ≥70 μg/dL. Zinc supplementation also significantly increased anti-CD3/CD28 and phytohemagglutinin-stimulated T cell proliferation, and the number of peripheral T cells (P < 0.05). When proliferation was expressed per number of T cells, the significant differences between groups were lost, suggesting that the zinc-induced enhancement of T cell proliferation was mainly due to an increase in the number of T cells. CONCLUSIONS: Zinc supplementation at 30 mg/d for 3 mo is effective in increasing serum zinc concentrations in nursing home elderly; however, not all zinc-deficient elderly reached adequate concentrations. The increase in serum zinc concentration was associated with the enhancement of T cell function mainly because of an increase in the number of T cells. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26817502/Effect_of_zinc_supplementation_on_serum_zinc_concentration_and_T_cell_proliferation_in_nursing_home_elderly:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.115188 DB - PRIME DP - Unbound Medicine ER -