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Intermittent control of hyperuricemia in the treatment of gout.
J Rheumatol. 1989 Sep; 16(9):1246-8.JR

Abstract

Fifty patients with gout were randomly allocated to one of 2 groups receiving allopurinol, either continuously or for 2 months every year. Patients with renal functional impairment or tophacous gout were excluded. Duration of treatment ranged from 2-4 years. Acute gouty arthritis occurred to a similar degree in the 2 groups during the first year, but thereafter attacks occurred with diminishing frequency in the continuous group compared with the intermittent group. We concluded that the intermittent administration of allopurinol as given here is less effective in controlling symptoms of gout than continuous therapy.

Authors+Show Affiliations

Bull PW
Department of Rheumatology, Charing Cross Hospital, London, UK.
Scott JT
No affiliation info available

MeSH

AllopurinolDrug Administration ScheduleGoutHumansMaleMiddle AgedRandomized Controlled Trials as TopicTime FactorsUric Acid

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2681764

Citation

Bull, P W., and J T. Scott. "Intermittent Control of Hyperuricemia in the Treatment of Gout." The Journal of Rheumatology, vol. 16, no. 9, 1989, pp. 1246-8.
Bull PW, Scott JT. Intermittent control of hyperuricemia in the treatment of gout. J Rheumatol. 1989;16(9):1246-8.
Bull, P. W., & Scott, J. T. (1989). Intermittent control of hyperuricemia in the treatment of gout. The Journal of Rheumatology, 16(9), 1246-8.
Bull PW, Scott JT. Intermittent Control of Hyperuricemia in the Treatment of Gout. J Rheumatol. 1989;16(9):1246-8. PubMed PMID: 2681764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent control of hyperuricemia in the treatment of gout. AU - Bull,P W, AU - Scott,J T, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 1246 EP - 8 JF - The Journal of rheumatology JO - J Rheumatol VL - 16 IS - 9 N2 - Fifty patients with gout were randomly allocated to one of 2 groups receiving allopurinol, either continuously or for 2 months every year. Patients with renal functional impairment or tophacous gout were excluded. Duration of treatment ranged from 2-4 years. Acute gouty arthritis occurred to a similar degree in the 2 groups during the first year, but thereafter attacks occurred with diminishing frequency in the continuous group compared with the intermittent group. We concluded that the intermittent administration of allopurinol as given here is less effective in controlling symptoms of gout than continuous therapy. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/2681764/Intermittent_control_of_hyperuricemia_in_the_treatment_of_gout_ DB - PRIME DP - Unbound Medicine ER -