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Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk.
J Nutr. 2016 Mar; 146(3):576-85.JN

Abstract

BACKGROUND

Mechanistic hypotheses suggest that vitamin D may contribute to the prevention of breast cancer. However, epidemiologic evidence is inconsistent, suggesting a potential effect modification by individual factors.

OBJECTIVE

Our objective was to perform exploratory analyses on the prospective associations between the plasma 25-hydroxyvitamin D [25(OH)D] concentration, polymorphisms of genes encoding for the vitamin D receptor (VDR) and vitamin D-binding protein (also known as gc-globulin or group-specific component, GC), and breast cancer risk, along with 2 potential modifiers: body mass index (BMI; in kg/m(2)) and alcohol intake.

METHODS

A nested case-control study was set up in the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort (1994-2007), involving 233 women with breast cancer and 466 matched controls (mean ± SD age: 49 ± 6 y). The plasma total 25(OH)D concentration and gene polymorphisms were assessed on samples obtained at baseline. Conditional logistic regression models were computed.

RESULTS

A higher plasma 25(OH)D concentration was associated with a decreased risk of breast cancer for women with a BMI < the median of 22.4 [OR quartile (Q)4 compared with Q1: 0.46; 95% CI: 0.23, 0.89; P-trend = 0.01, P-interaction = 0.002], whereas it was associated with an increased risk for women with a BMI ≥ the median (OR Q4 compared with Q1: 2.45; 95% CI: 1.13, 5.28; P-trend = 0.02, P-interaction = 0.002). A plasma 25(OH)D concentration ≥ 10 ng/mL was associated with a decreased risk of breast cancer for women with alcohol intakes ≥ the median of 7.1 g/d (OR ≥10 compared with <10 ng/mL: 0.50; 95% CI: 0.26, 0.95; P = 0.03, P-interaction = 0.03). The genetic analyses were consistent with the results observed with plasma 25(OH)D.

CONCLUSION

In this prospective study, BMI and alcohol intake modified the association between vitamin D [plasma 25(OH)D and vitamin D-related gene polymorphisms] and breast cancer risk. These effect modifications suggest explanations for discrepancies in results of previous studies. This trial was registered at clinicaltrials.gov as NCT00272428.

Authors+Show Affiliations

Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France; m.deschasaux@eren.smbh.univ-paris13.fr.Physiology Department, Necker Hospital, Inserm U845, Paris, France;Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France;Biochemistry Department, Jean Verdier Hospital, Inserm U698, Paris 13 University, Bondy, France;Biochemistry Department, Jean Verdier Hospital, Inserm U698, Paris 13 University, Bondy, France;Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France;Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France;Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France; Public Health Department, Avicenne Hospital, Bobigny, France;Conservatoire National des Arts et Métiers (CNAM), Genomics, Bioinformatics and Applications Team (EA4627), Paris, France; and.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France;Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France; Dermatology Department, Saint André Hospital, Bordeaux, France.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), French National Institute of Health and Medical Research (Inserm U1153), French National Institute for Agricultural Research (INRA U1125), French National Conservatory of Arts and Crafts (CNAM), Paris 13 University, Nutritional Epidemiology Research Team (EREN), Bobigny, France;

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26817718

Citation

Deschasaux, Mélanie, et al. "Weight Status and Alcohol Intake Modify the Association Between Vitamin D and Breast Cancer Risk." The Journal of Nutrition, vol. 146, no. 3, 2016, pp. 576-85.
Deschasaux M, Souberbielle JC, Latino-Martel P, et al. Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk. J Nutr. 2016;146(3):576-85.
Deschasaux, M., Souberbielle, J. C., Latino-Martel, P., Sutton, A., Charnaux, N., Druesne-Pecollo, N., Galan, P., Hercberg, S., Le Clerc, S., Kesse-Guyot, E., Ezzedine, K., & Touvier, M. (2016). Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk. The Journal of Nutrition, 146(3), 576-85. https://doi.org/10.3945/jn.115.221481
Deschasaux M, et al. Weight Status and Alcohol Intake Modify the Association Between Vitamin D and Breast Cancer Risk. J Nutr. 2016;146(3):576-85. PubMed PMID: 26817718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk. AU - Deschasaux,Mélanie, AU - Souberbielle,Jean-Claude, AU - Latino-Martel,Paule, AU - Sutton,Angela, AU - Charnaux,Nathalie, AU - Druesne-Pecollo,Nathalie, AU - Galan,Pilar, AU - Hercberg,Serge, AU - Le Clerc,Sigrid, AU - Kesse-Guyot,Emmanuelle, AU - Ezzedine,Khaled, AU - Touvier,Mathilde, Y1 - 2016/01/27/ PY - 2015/07/30/received PY - 2015/12/17/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/7/12/medline KW - 25-hydroxyvitamin D KW - alcohol intake KW - body mass index KW - breast cancer risk KW - nested case-control study KW - single nucleotide polymorphisms KW - vitamin D binding protein KW - vitamin D receptor SP - 576 EP - 85 JF - The Journal of nutrition JO - J. Nutr. VL - 146 IS - 3 N2 - BACKGROUND: Mechanistic hypotheses suggest that vitamin D may contribute to the prevention of breast cancer. However, epidemiologic evidence is inconsistent, suggesting a potential effect modification by individual factors. OBJECTIVE: Our objective was to perform exploratory analyses on the prospective associations between the plasma 25-hydroxyvitamin D [25(OH)D] concentration, polymorphisms of genes encoding for the vitamin D receptor (VDR) and vitamin D-binding protein (also known as gc-globulin or group-specific component, GC), and breast cancer risk, along with 2 potential modifiers: body mass index (BMI; in kg/m(2)) and alcohol intake. METHODS: A nested case-control study was set up in the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort (1994-2007), involving 233 women with breast cancer and 466 matched controls (mean ± SD age: 49 ± 6 y). The plasma total 25(OH)D concentration and gene polymorphisms were assessed on samples obtained at baseline. Conditional logistic regression models were computed. RESULTS: A higher plasma 25(OH)D concentration was associated with a decreased risk of breast cancer for women with a BMI < the median of 22.4 [OR quartile (Q)4 compared with Q1: 0.46; 95% CI: 0.23, 0.89; P-trend = 0.01, P-interaction = 0.002], whereas it was associated with an increased risk for women with a BMI ≥ the median (OR Q4 compared with Q1: 2.45; 95% CI: 1.13, 5.28; P-trend = 0.02, P-interaction = 0.002). A plasma 25(OH)D concentration ≥ 10 ng/mL was associated with a decreased risk of breast cancer for women with alcohol intakes ≥ the median of 7.1 g/d (OR ≥10 compared with <10 ng/mL: 0.50; 95% CI: 0.26, 0.95; P = 0.03, P-interaction = 0.03). The genetic analyses were consistent with the results observed with plasma 25(OH)D. CONCLUSION: In this prospective study, BMI and alcohol intake modified the association between vitamin D [plasma 25(OH)D and vitamin D-related gene polymorphisms] and breast cancer risk. These effect modifications suggest explanations for discrepancies in results of previous studies. This trial was registered at clinicaltrials.gov as NCT00272428. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/26817718/Weight_Status_and_Alcohol_Intake_Modify_the_Association_between_Vitamin_D_and_Breast_Cancer_Risk_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.115.221481 DB - PRIME DP - Unbound Medicine ER -