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Difficult case of Cronkhite-Canada syndrome with small intestinal bacterial overgrowth, Clostridium difficile infection and polymyalgia rheumatica.
BMJ Case Rep. 2016 Jan 27; 2016BC

Abstract

A 64-year-old woman presented with heavy diarrhoea, nausea and weight loss accompanied by alopecia and dystrophic fingernails and toenails. The preceding diagnosis of an inflammatory bowel disease, a common pitfall, was excluded by endoscopic work up. Instead, Cronkhite-Canada syndrome (CCS), a rare polyposis condition, was identified as the reason for this almost pathognomonic combination of diagnostic findings including various polyps throughout the entire intestine and ectodermal abnormalities. This case exemplifies common risks and complications in terms of gastrointestinal malabsorption, infections and small intestinal bacterial overgrowth (SIBO), including its treatment as well as a hereto unreported association with polymyalgia rheumatica. In CCS, long-term immunosuppressive therapy and close endoscopic cancer screening of the patient is essential. The treatment of vitamin deficiency and recurring SIBO helps to reduce symptoms.

Authors+Show Affiliations

Department of Internal Medicine III-Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.Department of Internal Medicine III-Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.Department of Internal Medicine III-Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.Department of Internal Medicine III-Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

26818813

Citation

Traussnigg, Stefan, et al. "Difficult Case of Cronkhite-Canada Syndrome With Small Intestinal Bacterial Overgrowth, Clostridium Difficile Infection and Polymyalgia Rheumatica." BMJ Case Reports, vol. 2016, 2016.
Traussnigg S, Dolak W, Trauner M, et al. Difficult case of Cronkhite-Canada syndrome with small intestinal bacterial overgrowth, Clostridium difficile infection and polymyalgia rheumatica. BMJ Case Rep. 2016;2016.
Traussnigg, S., Dolak, W., Trauner, M., & Kazemi-Shirazi, L. (2016). Difficult case of Cronkhite-Canada syndrome with small intestinal bacterial overgrowth, Clostridium difficile infection and polymyalgia rheumatica. BMJ Case Reports, 2016. https://doi.org/10.1136/bcr-2015-213465
Traussnigg S, et al. Difficult Case of Cronkhite-Canada Syndrome With Small Intestinal Bacterial Overgrowth, Clostridium Difficile Infection and Polymyalgia Rheumatica. BMJ Case Rep. 2016 Jan 27;2016 PubMed PMID: 26818813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Difficult case of Cronkhite-Canada syndrome with small intestinal bacterial overgrowth, Clostridium difficile infection and polymyalgia rheumatica. AU - Traussnigg,Stefan, AU - Dolak,Werner, AU - Trauner,Michael, AU - Kazemi-Shirazi,Lili, Y1 - 2016/01/27/ PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/10/19/medline JF - BMJ case reports JO - BMJ Case Rep VL - 2016 N2 - A 64-year-old woman presented with heavy diarrhoea, nausea and weight loss accompanied by alopecia and dystrophic fingernails and toenails. The preceding diagnosis of an inflammatory bowel disease, a common pitfall, was excluded by endoscopic work up. Instead, Cronkhite-Canada syndrome (CCS), a rare polyposis condition, was identified as the reason for this almost pathognomonic combination of diagnostic findings including various polyps throughout the entire intestine and ectodermal abnormalities. This case exemplifies common risks and complications in terms of gastrointestinal malabsorption, infections and small intestinal bacterial overgrowth (SIBO), including its treatment as well as a hereto unreported association with polymyalgia rheumatica. In CCS, long-term immunosuppressive therapy and close endoscopic cancer screening of the patient is essential. The treatment of vitamin deficiency and recurring SIBO helps to reduce symptoms. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/26818813/Difficult_case_of_Cronkhite_Canada_syndrome_with_small_intestinal_bacterial_overgrowth_Clostridium_difficile_infection_and_polymyalgia_rheumatica_ L2 - https://casereports.bmj.com/cgi/pmidlookup?view=long&pmid=26818813 DB - PRIME DP - Unbound Medicine ER -