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Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants.
Br J Nutr. 2016 Mar 28; 115(6):951-9.BJ

Abstract

The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (75-100 %) energy restriction (ER) interspersed with normal eating. This study aimed to characterise the early metabolic response to these varying degrees of ER, which occurs acutely and prior to weight loss. Ten (three female) healthy, overweight/obese participants (36 (SEM 5) years; 29·0 (sem 1·1) kg/m2) took part in this acute three-way cross-over study. Participants completed three 1-d dietary interventions in a randomised order with a 1-week washout period: isoenergetic intake, partial 75 % ER and total 100 % ER. Fasting and postprandial (6-h) metabolic responses to a liquid test meal were assessed the following morning via serial blood sampling and indirect calorimetry. Food intake was also recorded for two subsequent days of ad libitum intake. Relative to the isoenergetic control, postprandial glucose responses were increased following total ER (+142 %; P=0·015) and to a lesser extent after partial ER (+76 %; P=0·051). There was also a delay in the glucose time to peak after total ER only (P=0·024). Both total and partial ER interventions produced comparable reductions in postprandial TAG responses (-75 and -59 %, respectively; both P<0·05) and 3-d energy intake deficits of approximately 30 % (both P=0·015). Resting and meal-induced thermogenesis were not significantly affected by either ER intervention. In conclusion, our data demonstrate the ability of substantial ER to acutely alter postprandial glucose-lipid metabolism (with partial ER producing the more favourable overall response), as well as incomplete energy-intake compensation amongst overweight/obese participants. Further investigations are required to establish how metabolism adapts over time to the repeated perturbations experienced during IER, as well as the implications for long-term health.

Authors+Show Affiliations

1Nutrition, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7WG,UK.2Lighterlife UK Ltd,Cavendish House,Parkway,Harlow Business Park,Essex CM19 5QF,UK.1Nutrition, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7WG,UK.1Nutrition, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences,University of Surrey,Guildford GU2 7WG,UK.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26819200

Citation

Antoni, Rona, et al. "Investigation Into the Acute Effects of Total and Partial Energy Restriction On Postprandial Metabolism Among Overweight/obese Participants." The British Journal of Nutrition, vol. 115, no. 6, 2016, pp. 951-9.
Antoni R, Johnston KL, Collins AL, et al. Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants. Br J Nutr. 2016;115(6):951-9.
Antoni, R., Johnston, K. L., Collins, A. L., & Robertson, M. D. (2016). Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants. The British Journal of Nutrition, 115(6), 951-9. https://doi.org/10.1017/S0007114515005346
Antoni R, et al. Investigation Into the Acute Effects of Total and Partial Energy Restriction On Postprandial Metabolism Among Overweight/obese Participants. Br J Nutr. 2016 Mar 28;115(6):951-9. PubMed PMID: 26819200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation into the acute effects of total and partial energy restriction on postprandial metabolism among overweight/obese participants. AU - Antoni,Rona, AU - Johnston,Kelly L, AU - Collins,Adam L, AU - Robertson,M Denise, Y1 - 2016/01/28/ PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/7/22/medline KW - 3-OHB 3-β-hydroxybutyrate KW - Alternate-day fasting KW - CVD KW - Cardiometabolic risk KW - ER energy restriction KW - IER intermittent energy restriction KW - Intermittent energy restriction KW - Intermittent fasting KW - REE resting energy expenditure KW - Type 2 diabetes KW - dAUC decremental AUC KW - iAUC incremental AUC SP - 951 EP - 9 JF - The British journal of nutrition JO - Br J Nutr VL - 115 IS - 6 N2 - The intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (75-100 %) energy restriction (ER) interspersed with normal eating. This study aimed to characterise the early metabolic response to these varying degrees of ER, which occurs acutely and prior to weight loss. Ten (three female) healthy, overweight/obese participants (36 (SEM 5) years; 29·0 (sem 1·1) kg/m2) took part in this acute three-way cross-over study. Participants completed three 1-d dietary interventions in a randomised order with a 1-week washout period: isoenergetic intake, partial 75 % ER and total 100 % ER. Fasting and postprandial (6-h) metabolic responses to a liquid test meal were assessed the following morning via serial blood sampling and indirect calorimetry. Food intake was also recorded for two subsequent days of ad libitum intake. Relative to the isoenergetic control, postprandial glucose responses were increased following total ER (+142 %; P=0·015) and to a lesser extent after partial ER (+76 %; P=0·051). There was also a delay in the glucose time to peak after total ER only (P=0·024). Both total and partial ER interventions produced comparable reductions in postprandial TAG responses (-75 and -59 %, respectively; both P<0·05) and 3-d energy intake deficits of approximately 30 % (both P=0·015). Resting and meal-induced thermogenesis were not significantly affected by either ER intervention. In conclusion, our data demonstrate the ability of substantial ER to acutely alter postprandial glucose-lipid metabolism (with partial ER producing the more favourable overall response), as well as incomplete energy-intake compensation amongst overweight/obese participants. Further investigations are required to establish how metabolism adapts over time to the repeated perturbations experienced during IER, as well as the implications for long-term health. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26819200/Investigation_into_the_acute_effects_of_total_and_partial_energy_restriction_on_postprandial_metabolism_among_overweight/obese_participants_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515005346/type/journal_article DB - PRIME DP - Unbound Medicine ER -