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Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer.
Mass Spectrom (Tokyo). 2015; 4(1):A0038.MS

Abstract

We previously reported on the development of a portable mass spectrometer for the onsite screening of illicit drugs, but our previous sampling system could only be used for liquid samples. In this study, we report on an attempt to develop a probe heating method that also permits solid samples to be analyzed using a portable mass spectrometer. An aluminum rod is used as the sampling probe. The powdered sample is affixed to the sampling probe or a droplet of sample solution is placed on the tip of the probe and dried. The probe is then placed on a heater to vaporize the sample. The vapor is then introduced into the portable mass spectrometer and analyzed. With the heater temperature set to 130°C, the developed system detected 1 ng of methamphetamine, 1 ng of amphetamine, 3 ng of 3,4-methylenedioxymethamphetamine, 1 ng of 3,4-methylenedioxyamphetamine, and 0.3 ng of cocaine. Even from mixtures consisting of clove powder and methamphetamine powder, methamphetamine ions were detected by tandem mass spectrometry. The developed probe heating method provides a simple method for the analysis of solid samples. A portable mass spectrometer incorporating this method would thus be useful for the onsite screening of illicit drugs.

Authors+Show Affiliations

Hitachi, Ltd., Central Research Laboratory.Hitachi, Ltd., Central Research Laboratory.Hitachi, Ltd., Central Research Laboratory.Hitachi, Ltd., Central Research Laboratory.Hitachi, Ltd., Central Research Laboratory.Hitachi High-Technologies Corp.National Research Institute of Police Science.Hitachi, Ltd., Central Research Laboratory.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26819909

Citation

Kumano, Shun, et al. "Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer." Mass Spectrometry (Tokyo, Japan), vol. 4, no. 1, 2015, pp. A0038.
Kumano S, Sugiyama M, Yamada M, et al. Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer. Mass Spectrom (Tokyo). 2015;4(1):A0038.
Kumano, S., Sugiyama, M., Yamada, M., Nishimura, K., Hasegawa, H., Morokuma, H., Inoue, H., & Hashimoto, Y. (2015). Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer. Mass Spectrometry (Tokyo, Japan), 4(1), A0038. https://doi.org/10.5702/massspectrometry.A0038
Kumano S, et al. Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer. Mass Spectrom (Tokyo). 2015;4(1):A0038. PubMed PMID: 26819909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probe Heating Method for the Analysis of Solid Samples Using a Portable Mass Spectrometer. AU - Kumano,Shun, AU - Sugiyama,Masuyuki, AU - Yamada,Masuyoshi, AU - Nishimura,Kazushige, AU - Hasegawa,Hideki, AU - Morokuma,Hidetoshi, AU - Inoue,Hiroyuki, AU - Hashimoto,Yuichiro, Y1 - 2015/04/25/ PY - 2015/01/20/received PY - 2015/03/17/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/1/29/medline KW - illicit drug KW - onsite screening KW - portable mass spectrometer KW - solid sample analysis SP - A0038 EP - A0038 JF - Mass spectrometry (Tokyo, Japan) JO - Mass Spectrom (Tokyo) VL - 4 IS - 1 N2 - We previously reported on the development of a portable mass spectrometer for the onsite screening of illicit drugs, but our previous sampling system could only be used for liquid samples. In this study, we report on an attempt to develop a probe heating method that also permits solid samples to be analyzed using a portable mass spectrometer. An aluminum rod is used as the sampling probe. The powdered sample is affixed to the sampling probe or a droplet of sample solution is placed on the tip of the probe and dried. The probe is then placed on a heater to vaporize the sample. The vapor is then introduced into the portable mass spectrometer and analyzed. With the heater temperature set to 130°C, the developed system detected 1 ng of methamphetamine, 1 ng of amphetamine, 3 ng of 3,4-methylenedioxymethamphetamine, 1 ng of 3,4-methylenedioxyamphetamine, and 0.3 ng of cocaine. Even from mixtures consisting of clove powder and methamphetamine powder, methamphetamine ions were detected by tandem mass spectrometry. The developed probe heating method provides a simple method for the analysis of solid samples. A portable mass spectrometer incorporating this method would thus be useful for the onsite screening of illicit drugs. SN - 2187-137X UR - https://www.unboundmedicine.com/medline/citation/26819909/Probe_Heating_Method_for_the_Analysis_of_Solid_Samples_Using_a_Portable_Mass_Spectrometer L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26819909/ DB - PRIME DP - Unbound Medicine ER -