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Asymmetric distribution in twin screw granulation.
Eur J Pharm Biopharm. 2016 Sep; 106:50-8.EJ

Abstract

Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill level was determined. High flow asymmetry at low fill level negatively affects granule nucleation leading to high variance in final uniformity. Wetting of material during nucleation was identified as a critical parameter in determining final granule uniformity and fill level is highlighted as a crucial control factor in achieving this. Flow asymmetry of dry material in conveying zones upstream of binder fluid injection leads to poor non-uniform wetting at nucleation and results in heterogeneous final product. The granule formation mechanism of 60°F kneading blocks is suggested to be primarily breakage of agglomerates formed during nucleation. Optimisation of screw configuration would be required to provide secondary growth. This work shows how fill dependent flow regimes affect granulation mechanisms.

Authors+Show Affiliations

School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: TXC227@bham.ac.uk.School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, UK.Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, UK.Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield SK10 2NA, UK.School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26820919

Citation

Chan Seem, Tim, et al. "Asymmetric Distribution in Twin Screw Granulation." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 106, 2016, pp. 50-8.
Chan Seem T, Rowson NA, Gabbott I, et al. Asymmetric distribution in twin screw granulation. Eur J Pharm Biopharm. 2016;106:50-8.
Chan Seem, T., Rowson, N. A., Gabbott, I., de Matas, M., Reynolds, G. K., & Ingram, A. (2016). Asymmetric distribution in twin screw granulation. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 106, 50-8. https://doi.org/10.1016/j.ejpb.2016.01.013
Chan Seem T, et al. Asymmetric Distribution in Twin Screw Granulation. Eur J Pharm Biopharm. 2016;106:50-8. PubMed PMID: 26820919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetric distribution in twin screw granulation. AU - Chan Seem,Tim, AU - Rowson,Neil A, AU - Gabbott,Ian, AU - de Matas,Marcel, AU - Reynolds,Gavin K, AU - Ingram,Andy, Y1 - 2016/01/25/ PY - 2015/08/28/received PY - 2016/01/08/revised PY - 2016/01/19/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2017/2/28/medline KW - Continuous processes KW - Nucleation KW - PEPT KW - Pharmaceutical technology KW - Twin screw granulation SP - 50 EP - 8 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 106 N2 - Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill level was determined. High flow asymmetry at low fill level negatively affects granule nucleation leading to high variance in final uniformity. Wetting of material during nucleation was identified as a critical parameter in determining final granule uniformity and fill level is highlighted as a crucial control factor in achieving this. Flow asymmetry of dry material in conveying zones upstream of binder fluid injection leads to poor non-uniform wetting at nucleation and results in heterogeneous final product. The granule formation mechanism of 60°F kneading blocks is suggested to be primarily breakage of agglomerates formed during nucleation. Optimisation of screw configuration would be required to provide secondary growth. This work shows how fill dependent flow regimes affect granulation mechanisms. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/26820919/Asymmetric_distribution_in_twin_screw_granulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(16)00037-0 DB - PRIME DP - Unbound Medicine ER -