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Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent.

Abstract

Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food.

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  • Authors+Show Affiliations

    ,

    Taiwan Indigena Botanica Co., Ltd., Taipei 11458, Taiwan. jasmineycs@yahoo.com.tw.

    ,

    Department of Food Sciences, National Chiayi University, Chiayi 60004, Taiwan. Tracy12095238@hotmail.com.

    ,

    Department of Food Sciences, National Chiayi University, Chiayi 60004, Taiwan. even78819@gmail.com.

    ,

    Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11042, Taiwan. f96b47117@ntu.edu.tw. Department of Traditional Chinese Medicine, Taipei Medical University Hospital, Taipei 10042, Taiwan. f96b47117@ntu.edu.tw.

    ,

    Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. yifanhan2014@gmail.com.

    ,

    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA. cuizhibin1985@gmail.com.

    ,

    Biochemical Process Technology Department, Center of Excellence for Drug Development, Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 30058, Taiwan. d99b22003@ntu.edu.tw.

    Department of Food Sciences, National Chiayi University, Chiayi 60004, Taiwan. scwu@mail.ncyu.edu.tw.

    Source

    Molecules (Basel, Switzerland) 21:2 2016 Jan 26 pg 140

    MeSH

    Animals
    Anti-Inflammatory Agents
    Antioxidants
    Butanols
    Disease Models, Animal
    Hyperuricemia
    Macrophages
    Mice
    Mice, Inbred ICR
    Plant Extracts
    RAW 264.7 Cells
    Synsepalum
    Uric Acid
    Xanthine Oxidase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26821007

    Citation

    Shi, Yeu-Ching, et al. "Miracle Fruit (Synsepalum Dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent." Molecules (Basel, Switzerland), vol. 21, no. 2, 2016, p. 140.
    Shi YC, Lin KS, Jhai YF, et al. Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules. 2016;21(2):140.
    Shi, Y. C., Lin, K. S., Jhai, Y. F., Lee, B. H., Han, Y., Cui, Z., ... Wu, S. C. (2016). Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules (Basel, Switzerland), 21(2), p. 140. doi:10.3390/molecules21020140.
    Shi YC, et al. Miracle Fruit (Synsepalum Dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. Molecules. 2016 Jan 26;21(2):140. PubMed PMID: 26821007.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent. AU - Shi,Yeu-Ching, AU - Lin,Kai-Sian, AU - Jhai,Yi-Fen, AU - Lee,Bao-Hong, AU - Han,Yifan, AU - Cui,Zhibin, AU - Hsu,Wei-Hsuan, AU - Wu,She-Ching, Y1 - 2016/01/26/ PY - 2015/12/31/received PY - 2016/01/15/revised PY - 2016/01/20/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/11/12/medline KW - anti-hyperuricaemia agent KW - miracle fruit KW - monosodium urate (MSU) KW - oxonic acid potassium salt KW - xanthine oxidase SP - 140 EP - 140 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 21 IS - 2 N2 - Miracle fruit (Synsepalum dulcificum) belongs to the Sapotaceae family. It can change flavors on taste buds, transforming acidic tastes to sweet. We evaluated various miracle fruit extracts, including water, butanol, ethyl acetate (EA), and hexane fractions, to determine its antioxidant effects. These extracts isolated from miracle fruit exerted potential for reduction of uric acid and inhibited xanthine oxidase activity in vitro and in monosodiumurate (MSU)-treated RAW264.7 macrophages. Moreover, we also found that the butanol extracts of miracle fruit attenuated oxonic acid potassium salt-induced hyperuricaemia in ICR mice by lowering serum uric acid levels and activating hepatic xanthine oxidase. These effects were equal to those of allopurinol, suggesting that the butanol extract of miracle fruit could be developed as a novel anti-hyperuricaemia agent or health food. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/26821007/Miracle_Fruit__Synsepalum_dulcificum__Exhibits_as_a_Novel_Anti_Hyperuricaemia_Agent_ L2 - http://www.mdpi.com/resolver?pii=molecules21020140 DB - PRIME DP - Unbound Medicine ER -