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Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo.
Int J Pharm. 2016 Mar 30; 501(1-2):1-9.IJ

Abstract

Nanoparticulate drug delivery systems, mucoadhesive polymers and penetration enhancers have been used individually to overcome ocular barriers and increase bioavailability to eye tissues. However the combined influence of mucoadhesive polymer coating and penetration enhancers on NP permeability has not been investigated. Hence, in this study, three types of core-shell nanoparticles with same hydrophobic core but different hydrophilic mucoadhesive shells were developed. Initially the influence of a single penetration enhancer (PE) [benzalkonium chloride (BAC)] on ocular permeability of all the three core-shell nanoparticles was studied. Then ocular permeability of a single nanoparticle system [polycaprolactone-pluronicF68 (PCL-PF68)] in presence of different types of PEs namely BAC, capric acid (CA), EDTA, sodium glycocolate (SG) and sodium taurocholate (ST) was studied. The results indicated that BAC differentially enhanced ocular permeability of nanoparticles depending on their surface properties. All the PEs except EDTA enhanced ocular permeability of PCL-PF68 nanoparticles to anterior part of the eye. BAC and CA showed increased bioavailability of PCL-PF68 nanoparticles in conjunctiva, SG in cornea, iris and ciliary body, and ST in cornea. Overall, the combination of PEs and surface properties of nanoparticles can differentially influence ocular permeability and bioavailability and can be advantageously used to develop improved ocular drug delivery systems.

Authors+Show Affiliations

Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India.Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, India. Electronic address: dsk@iitk.ac.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26821059

Citation

Mahaling, Binapani, and Dhirendra S. Katti. "Understanding the Influence of Surface Properties of Nanoparticles and Penetration Enhancers for Improving Bioavailability in Eye Tissues in Vivo." International Journal of Pharmaceutics, vol. 501, no. 1-2, 2016, pp. 1-9.
Mahaling B, Katti DS. Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo. Int J Pharm. 2016;501(1-2):1-9.
Mahaling, B., & Katti, D. S. (2016). Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo. International Journal of Pharmaceutics, 501(1-2), 1-9. https://doi.org/10.1016/j.ijpharm.2016.01.053
Mahaling B, Katti DS. Understanding the Influence of Surface Properties of Nanoparticles and Penetration Enhancers for Improving Bioavailability in Eye Tissues in Vivo. Int J Pharm. 2016 Mar 30;501(1-2):1-9. PubMed PMID: 26821059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding the influence of surface properties of nanoparticles and penetration enhancers for improving bioavailability in eye tissues in vivo. AU - Mahaling,Binapani, AU - Katti,Dhirendra S, Y1 - 2016/01/25/ PY - 2015/12/03/received PY - 2016/01/20/revised PY - 2016/01/21/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/12/15/medline KW - Benzalkonium chloride KW - Capric acid KW - EDTA KW - Nanoparticles KW - Non-invasive KW - Ocular drug delivery KW - Penetration enhancer KW - Pluronic F68 KW - Sodium glycocholate KW - Sodium taurocholate SP - 1 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 501 IS - 1-2 N2 - Nanoparticulate drug delivery systems, mucoadhesive polymers and penetration enhancers have been used individually to overcome ocular barriers and increase bioavailability to eye tissues. However the combined influence of mucoadhesive polymer coating and penetration enhancers on NP permeability has not been investigated. Hence, in this study, three types of core-shell nanoparticles with same hydrophobic core but different hydrophilic mucoadhesive shells were developed. Initially the influence of a single penetration enhancer (PE) [benzalkonium chloride (BAC)] on ocular permeability of all the three core-shell nanoparticles was studied. Then ocular permeability of a single nanoparticle system [polycaprolactone-pluronicF68 (PCL-PF68)] in presence of different types of PEs namely BAC, capric acid (CA), EDTA, sodium glycocolate (SG) and sodium taurocholate (ST) was studied. The results indicated that BAC differentially enhanced ocular permeability of nanoparticles depending on their surface properties. All the PEs except EDTA enhanced ocular permeability of PCL-PF68 nanoparticles to anterior part of the eye. BAC and CA showed increased bioavailability of PCL-PF68 nanoparticles in conjunctiva, SG in cornea, iris and ciliary body, and ST in cornea. Overall, the combination of PEs and surface properties of nanoparticles can differentially influence ocular permeability and bioavailability and can be advantageously used to develop improved ocular drug delivery systems. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/26821059/Understanding_the_influence_of_surface_properties_of_nanoparticles_and_penetration_enhancers_for_improving_bioavailability_in_eye_tissues_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(16)30053-9 DB - PRIME DP - Unbound Medicine ER -