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Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood.
Environ Res. 2016 Apr; 146:379-87.ER

Abstract

BACKGROUND

Bisphenol A (BPA) is a chemical used extensively worldwide in the manufacture of plastic polymers. The environmental obesogen hypothesis suggests that early life exposure to endocrine disrupting chemicals such as BPA may increase the risk for wt gain later in childhood but few prospective epidemiological studies have investigated this relationship.

OBJECTIVES

We examined the association of early life BPA exposure with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the RHEA pregnancy cohort in Crete, Greece.

METHODS

BPA concentrations were measured in spot urine samples collected at the 1st trimester of pregnancy) and from children at 2.5 and 4 years of age. We measured birth wt, body mass index (BMI) from 6 months to 4 years of age, waist circumference, skinfold thickness, blood pressure, serum lipids, C-reactive protein, and adipokines at 4 years of age. BMI growth trajectories from birth to 4 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable regression analyses.

RESULTS

The prevalence of overweight/obesity was 9% at 2, 13% at 3% and 17% at 4 years of age. Geometric mean BPA concentrations were 1.2μg/g creatinine±7.9 in 1st trimester, 5.1μg/g±13.3 in 2.5 years and 1.9μg/g±4.9 in 4 years. After confounder adjustment, each 10-fold increase in BPA at 4 years was associated with a higher BMI z-score (adj. β=0.2; 95% CI: 0.01, 0.4), waist circumference (adj. β=1.2; 95% CI: 0.1, 2.2) and sum of skinfold thickness (adj. β=3.7mm; 95% CI: 0.7, 6.7) at 4 years. Prenatal BPA was negatively associated with BMI and adiposity measures in girls and positively in boys. We found no associations of early life exposure to BPA with other offspring cardiometabolic risk factors.

CONCLUSIONS

Prenatal BPA exposure was not consistently associated with offspring growth and adiposity measures but higher early childhood BPA was associated with excess child adiposity.

Authors+Show Affiliations

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. Electronic address: m.vafeiadi@med.uoc.gr.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Environmental Chemical Processes Laboratory (ECPL), Department of Chemistry, University of Crete, Heraklion, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.Environmental Chemical Processes Laboratory (ECPL), Department of Chemistry, University of Crete, Heraklion, Greece.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Hospital del Mar Research Institute (IMIM), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26821262

Citation

Vafeiadi, Marina, et al. "Association of Early Life Exposure to Bisphenol a With Obesity and Cardiometabolic Traits in Childhood." Environmental Research, vol. 146, 2016, pp. 379-87.
Vafeiadi M, Roumeliotaki T, Myridakis A, et al. Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environ Res. 2016;146:379-87.
Vafeiadi, M., Roumeliotaki, T., Myridakis, A., Chalkiadaki, G., Fthenou, E., Dermitzaki, E., Karachaliou, M., Sarri, K., Vassilaki, M., Stephanou, E. G., Kogevinas, M., & Chatzi, L. (2016). Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environmental Research, 146, 379-87. https://doi.org/10.1016/j.envres.2016.01.017
Vafeiadi M, et al. Association of Early Life Exposure to Bisphenol a With Obesity and Cardiometabolic Traits in Childhood. Environ Res. 2016;146:379-87. PubMed PMID: 26821262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. AU - Vafeiadi,Marina, AU - Roumeliotaki,Theano, AU - Myridakis,Antonis, AU - Chalkiadaki,Georgia, AU - Fthenou,Eleni, AU - Dermitzaki,Eirini, AU - Karachaliou,Marianna, AU - Sarri,Katerina, AU - Vassilaki,Maria, AU - Stephanou,Euripides G, AU - Kogevinas,Manolis, AU - Chatzi,Leda, Y1 - 2016/01/25/ PY - 2015/11/09/received PY - 2016/01/11/revised PY - 2016/01/13/accepted PY - 2016/1/29/entrez PY - 2016/1/29/pubmed PY - 2016/6/28/medline KW - Bisphenol A KW - Cardiometabolic risk KW - Children KW - Obesity KW - Pregnancy SP - 379 EP - 87 JF - Environmental research JO - Environ. Res. VL - 146 N2 - BACKGROUND: Bisphenol A (BPA) is a chemical used extensively worldwide in the manufacture of plastic polymers. The environmental obesogen hypothesis suggests that early life exposure to endocrine disrupting chemicals such as BPA may increase the risk for wt gain later in childhood but few prospective epidemiological studies have investigated this relationship. OBJECTIVES: We examined the association of early life BPA exposure with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the RHEA pregnancy cohort in Crete, Greece. METHODS: BPA concentrations were measured in spot urine samples collected at the 1st trimester of pregnancy) and from children at 2.5 and 4 years of age. We measured birth wt, body mass index (BMI) from 6 months to 4 years of age, waist circumference, skinfold thickness, blood pressure, serum lipids, C-reactive protein, and adipokines at 4 years of age. BMI growth trajectories from birth to 4 years were estimated by mixed effects models with fractional polynomials of age. Adjusted associations were obtained via multivariable regression analyses. RESULTS: The prevalence of overweight/obesity was 9% at 2, 13% at 3% and 17% at 4 years of age. Geometric mean BPA concentrations were 1.2μg/g creatinine±7.9 in 1st trimester, 5.1μg/g±13.3 in 2.5 years and 1.9μg/g±4.9 in 4 years. After confounder adjustment, each 10-fold increase in BPA at 4 years was associated with a higher BMI z-score (adj. β=0.2; 95% CI: 0.01, 0.4), waist circumference (adj. β=1.2; 95% CI: 0.1, 2.2) and sum of skinfold thickness (adj. β=3.7mm; 95% CI: 0.7, 6.7) at 4 years. Prenatal BPA was negatively associated with BMI and adiposity measures in girls and positively in boys. We found no associations of early life exposure to BPA with other offspring cardiometabolic risk factors. CONCLUSIONS: Prenatal BPA exposure was not consistently associated with offspring growth and adiposity measures but higher early childhood BPA was associated with excess child adiposity. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/26821262/Association_of_early_life_exposure_to_bisphenol_A_with_obesity_and_cardiometabolic_traits_in_childhood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(16)30016-0 DB - PRIME DP - Unbound Medicine ER -