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Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature.
Int J Clin Exp Pathol 2015; 8(11):15402-6IJ

Abstract

Glomus tumor is an uncommon tumor usually presenting in the dermis. Rarely, it occurred in visceral organs including stomach, liver and long. The majority of glomus tumors were benign. Herein, we present a case of glomus tumor located in the left lobe of the lung in a 49 year-old Chinese male. An irregular mass measuring 3 cm was detected by imaging examination because of his suffering from cough, dyspnea and chest pain. Histologically, the tumor is composed predominantly of sheets of ovoid to round cells with clear border, pale cytoplasm and fine granular chromatin. The mitotic count was less than 5 per 50 HPF. The tumor focally invaded the surrounding normal bronchial and alveolar tissue. Immunohistochemical staining showed that the cells were diffusely positive for SMA, caldesmon, and vimentin. The Ki-67 proliferation index was approximately 20%. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with glomus tumor of uncertain malignant potential.

Authors+Show Affiliations

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China.

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26823902

Citation

Wan, Peng-Zhi, et al. "Glomus Tumor of Uncertain Malignant Potential of the Lung: a Case Report and Review of Literature." International Journal of Clinical and Experimental Pathology, vol. 8, no. 11, 2015, pp. 15402-6.
Wan PZ, Han Q, Wang EH, et al. Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature. Int J Clin Exp Pathol. 2015;8(11):15402-6.
Wan, P. Z., Han, Q., Wang, E. H., & Lin, X. Y. (2015). Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature. International Journal of Clinical and Experimental Pathology, 8(11), pp. 15402-6.
Wan PZ, et al. Glomus Tumor of Uncertain Malignant Potential of the Lung: a Case Report and Review of Literature. Int J Clin Exp Pathol. 2015;8(11):15402-6. PubMed PMID: 26823902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomus tumor of uncertain malignant potential of the lung: a case report and review of literature. AU - Wan,Peng-Zhi, AU - Han,Qiang, AU - Wang,En-Hua, AU - Lin,Xu-Yong, Y1 - 2015/11/01/ PY - 2015/09/07/received PY - 2015/10/21/accepted PY - 2016/1/30/entrez PY - 2016/1/30/pubmed PY - 2016/10/25/medline KW - Glomus tumor KW - pulmonary neoplasm KW - uncertain malignant potential SP - 15402 EP - 6 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 8 IS - 11 N2 - Glomus tumor is an uncommon tumor usually presenting in the dermis. Rarely, it occurred in visceral organs including stomach, liver and long. The majority of glomus tumors were benign. Herein, we present a case of glomus tumor located in the left lobe of the lung in a 49 year-old Chinese male. An irregular mass measuring 3 cm was detected by imaging examination because of his suffering from cough, dyspnea and chest pain. Histologically, the tumor is composed predominantly of sheets of ovoid to round cells with clear border, pale cytoplasm and fine granular chromatin. The mitotic count was less than 5 per 50 HPF. The tumor focally invaded the surrounding normal bronchial and alveolar tissue. Immunohistochemical staining showed that the cells were diffusely positive for SMA, caldesmon, and vimentin. The Ki-67 proliferation index was approximately 20%. Based on morphologic features and the immunohistochemical profile, the tumor was consistent with glomus tumor of uncertain malignant potential. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/26823902/Glomus_tumor_of_uncertain_malignant_potential_of_the_lung:_a_case_report_and_review_of_literature_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26823902/ DB - PRIME DP - Unbound Medicine ER -