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Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents.
Metab Syndr Relat Disord. 2016 Apr; 14(3):167-74.MS

Abstract

BACKGROUND

Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults. We examined the relationship among SUA, [25(OH)D], PTH, and inflammation in obese adolescents, in obese adolescents with and without MS.

METHODS

Body mass index, body composition, 25(OH)D, PTH, fasting lipids, glucose, high-sensitivity C-reactive protein (hs-CRP), SUA, hemoglobin A1c (HbA1c), insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) were evaluated in 152 obese adolescents.

RESULTS

Hyperuricemia [SUA ≥ 6.0 mg/dL (357 μM)] was present in 54.6% of entire cohort without significant ethnic/racial differences. While SUA was negatively correlated with high-density lipoprotein cholesterol (HDL-C) and 25(OH)D (P < 0.01), it was positively correlated with fat mass (FM), PTH, PTH:25(OH)D, and hs-CRP (P < 0.01). Vitamin D deficiency [25(OH)D <50 nM] was present in 47.4% of subjects, and PTH and 25(OH)D were inversely correlated (P < 0.0001). FM was negatively correlated with 25(OH)D (r = -0.29; P < 0.001), but was positively correlated with PTH (P < 0.0001). MS was identified in 53.3% of cohort with higher FM, SUA, hs-CRP, HOMA-IR, PTH, and PTH:25(OH)D ratio than the non-MS subgroup (P < 0.001) with similar 25(OH)D status. Multiple regression analysis showed that the PTH:25(OH)D ratio mediated the relationship between SUA and hs-CRP (β = 0.19, P < 0.05 to β = 0.15, P = 0.19).

CONCLUSIONS

Hyperuricemia is strongly associated with PTH and hs-CRP levels independent of vitamin D status. The relationship between SUA and low-grade inflammation is mediated by the PTH:25(OH)D ratio in obese adolescents.

Authors+Show Affiliations

1 Division of Pediatric Endocrinology, Department of Pediatrics, University of Tennessee Health Science Center , Le Bonheur Research Center, Memphis, Tennessee.2 Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26824485

Citation

Alemzadeh, Ramin, and Jessica Kichler. "Uric Acid-Induced Inflammation Is Mediated By the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents." Metabolic Syndrome and Related Disorders, vol. 14, no. 3, 2016, pp. 167-74.
Alemzadeh R, Kichler J. Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. Metab Syndr Relat Disord. 2016;14(3):167-74.
Alemzadeh, R., & Kichler, J. (2016). Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. Metabolic Syndrome and Related Disorders, 14(3), 167-74. https://doi.org/10.1089/met.2015.0099
Alemzadeh R, Kichler J. Uric Acid-Induced Inflammation Is Mediated By the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. Metab Syndr Relat Disord. 2016;14(3):167-74. PubMed PMID: 26824485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uric Acid-Induced Inflammation Is Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents. AU - Alemzadeh,Ramin, AU - Kichler,Jessica, Y1 - 2016/01/29/ PY - 2016/1/30/entrez PY - 2016/1/30/pubmed PY - 2016/12/24/medline SP - 167 EP - 74 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 14 IS - 3 N2 - BACKGROUND: Elevated serum uric acid (SUA) level is strongly associated with prevalence of metabolic syndrome (MS), elevated parathyroid hormone (PTH) levels, and 25-hydroxyvitamin D [25(OH)D] insufficiency in adults. We examined the relationship among SUA, [25(OH)D], PTH, and inflammation in obese adolescents, in obese adolescents with and without MS. METHODS: Body mass index, body composition, 25(OH)D, PTH, fasting lipids, glucose, high-sensitivity C-reactive protein (hs-CRP), SUA, hemoglobin A1c (HbA1c), insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) were evaluated in 152 obese adolescents. RESULTS: Hyperuricemia [SUA ≥ 6.0 mg/dL (357 μM)] was present in 54.6% of entire cohort without significant ethnic/racial differences. While SUA was negatively correlated with high-density lipoprotein cholesterol (HDL-C) and 25(OH)D (P < 0.01), it was positively correlated with fat mass (FM), PTH, PTH:25(OH)D, and hs-CRP (P < 0.01). Vitamin D deficiency [25(OH)D <50 nM] was present in 47.4% of subjects, and PTH and 25(OH)D were inversely correlated (P < 0.0001). FM was negatively correlated with 25(OH)D (r = -0.29; P < 0.001), but was positively correlated with PTH (P < 0.0001). MS was identified in 53.3% of cohort with higher FM, SUA, hs-CRP, HOMA-IR, PTH, and PTH:25(OH)D ratio than the non-MS subgroup (P < 0.001) with similar 25(OH)D status. Multiple regression analysis showed that the PTH:25(OH)D ratio mediated the relationship between SUA and hs-CRP (β = 0.19, P < 0.05 to β = 0.15, P = 0.19). CONCLUSIONS: Hyperuricemia is strongly associated with PTH and hs-CRP levels independent of vitamin D status. The relationship between SUA and low-grade inflammation is mediated by the PTH:25(OH)D ratio in obese adolescents. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/26824485/Uric_Acid_Induced_Inflammation_Is_Mediated_by_the_Parathyroid_Hormone:25_Hydroxyvitamin_D_Ratio_in_Obese_Adolescents_ L2 - https://www.liebertpub.com/doi/full/10.1089/met.2015.0099?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -