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Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial.
Br J Nutr 2016; 115(4):644-9BJ

Abstract

Concerns have been raised about the benefits of Fe-containing supplements on infant birth weight among women with normal/high Hb levels at baseline. Thus far, no clinical trials have examined whether the effects of prenatal Fe-containing supplements on birth weight vary by maternal Hb levels. We compared the effects of Fe-folic acid (IFA) or multiple micronutrients (MMN) with folic acid (FA) supplements on birth weight among pregnant women with mild/no anaemia or high Hb levels. A double-blind randomised controlled trial was conducted in 2006-2009. In total, 18 775 pregnant women with mild/no anaemia (145 g/l) baseline Hb levels, IFA and MMN supplements increased birth weight by 91·44 (95% CI 3·37, 179·51) g and 107·63 (95% CI 21·98, 193·28) g (P<0·05), respectively, compared with the FA group. No differences were found between the IFA and the MMN group, regardless of maternal Hb concentration. In conclusion, the effects of Fe-containing supplements on birth weight depended on baseline Hb concentrations. The Fe-containing supplements improved birth weight in women with very high Hb levels before 20 weeks of gestation.

Authors+Show Affiliations

1Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health,Peking University Health Science Center,Beijing 100191,People's Republic of China.2Division of Nutrition,Physical Activity and Obesity,National Center for Chronic Disease Prevention and Health Promotion,Centers for Disease Control and Prevention (CDC),Atlanta,GA 30329-4027,USA.1Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health,Peking University Health Science Center,Beijing 100191,People's Republic of China.1Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health,Peking University Health Science Center,Beijing 100191,People's Republic of China.1Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health,Peking University Health Science Center,Beijing 100191,People's Republic of China.2Division of Nutrition,Physical Activity and Obesity,National Center for Chronic Disease Prevention and Health Promotion,Centers for Disease Control and Prevention (CDC),Atlanta,GA 30329-4027,USA.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26824731

Citation

Wang, Linlin, et al. "Modifying Effects of Maternal Hb Concentration On Infant Birth Weight in Women Receiving Prenatal Iron-containing Supplements: a Randomised Controlled Trial." The British Journal of Nutrition, vol. 115, no. 4, 2016, pp. 644-9.
Wang L, Mei Z, Li H, et al. Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial. Br J Nutr. 2016;115(4):644-9.
Wang, L., Mei, Z., Li, H., Zhang, Y., Liu, J., & Serdula, M. K. (2016). Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial. The British Journal of Nutrition, 115(4), pp. 644-9. doi:10.1017/S0007114515004870.
Wang L, et al. Modifying Effects of Maternal Hb Concentration On Infant Birth Weight in Women Receiving Prenatal Iron-containing Supplements: a Randomised Controlled Trial. Br J Nutr. 2016 Feb 28;115(4):644-9. PubMed PMID: 26824731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial. AU - Wang,Linlin, AU - Mei,Zuguo, AU - Li,Hongtian, AU - Zhang,Yali, AU - Liu,Jianmeng, AU - Serdula,Mary K, PY - 2016/1/30/entrez PY - 2016/1/30/pubmed PY - 2016/6/9/medline KW - Birth weight KW - FA folic acid KW - High maternal Hb KW - IFA Fe–folic acid KW - Iron-containing supplements KW - LBW low birth weight KW - MMN multiple micronutrients KW - RCT randomised controlled trial SP - 644 EP - 9 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 4 N2 - Concerns have been raised about the benefits of Fe-containing supplements on infant birth weight among women with normal/high Hb levels at baseline. Thus far, no clinical trials have examined whether the effects of prenatal Fe-containing supplements on birth weight vary by maternal Hb levels. We compared the effects of Fe-folic acid (IFA) or multiple micronutrients (MMN) with folic acid (FA) supplements on birth weight among pregnant women with mild/no anaemia or high Hb levels. A double-blind randomised controlled trial was conducted in 2006-2009. In total, 18 775 pregnant women with mild/no anaemia (145 g/l) baseline Hb levels, IFA and MMN supplements increased birth weight by 91·44 (95% CI 3·37, 179·51) g and 107·63 (95% CI 21·98, 193·28) g (P<0·05), respectively, compared with the FA group. No differences were found between the IFA and the MMN group, regardless of maternal Hb concentration. In conclusion, the effects of Fe-containing supplements on birth weight depended on baseline Hb concentrations. The Fe-containing supplements improved birth weight in women with very high Hb levels before 20 weeks of gestation. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26824731/Modifying_effects_of_maternal_Hb_concentration_on_infant_birth_weight_in_women_receiving_prenatal_iron_containing_supplements:_a_randomised_controlled_trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515004870/type/journal_article DB - PRIME DP - Unbound Medicine ER -