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Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats.
Hum Exp Toxicol 2016; 35(12):1305-1311HE

Abstract

The present study was undertaken to evaluate the effect of diallylsulphide (DAS) against mercuric chloride (HgCl2)-induced oxidative stress in rat livers. Rats were randomly divided into four groups of six rats each and exposed to HgCl2 (50 mg/kg/body weight (b.w.)) intraperitoneally and/or DAS (200 mg/kg/b.w.) by gavage. HgCl2 administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels (p < 0.05) with reduction in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). However, treatment with DAS markedly attenuated HgCl2-induced biochemical alterations in liver and serum transaminases (AST and ALT; p < 0.05). Further, biochemical results were confirmed by histopathological changes as compared to HgCl2-intoxicated rats. Histopathology of liver also showed that administration of DAS significantly reduced the damage generated by HgCl2 The present study suggests that DAS shows antioxidant activity and plays a protective role against mercury-induced oxidative damage in the rat livers.

Authors+Show Affiliations

Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia sansar@ksu.edu.sa.Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu Sabah, Malaysia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26825963

Citation

Ansar, S, and M Iqbal. "Protective Effect of Diallylsulphide Against Mercuric Chloride-induced Hepatic Injury in Rats." Human & Experimental Toxicology, vol. 35, no. 12, 2016, pp. 1305-1311.
Ansar S, Iqbal M. Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats. Hum Exp Toxicol. 2016;35(12):1305-1311.
Ansar, S., & Iqbal, M. (2016). Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats. Human & Experimental Toxicology, 35(12), pp. 1305-1311.
Ansar S, Iqbal M. Protective Effect of Diallylsulphide Against Mercuric Chloride-induced Hepatic Injury in Rats. Hum Exp Toxicol. 2016;35(12):1305-1311. PubMed PMID: 26825963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats. AU - Ansar,S, AU - Iqbal,M, Y1 - 2016/01/28/ PY - 2016/1/31/pubmed PY - 2017/2/10/medline PY - 2016/1/31/entrez KW - Mercury KW - antioxidant enzymes KW - diallylsulphide KW - liver damage SP - 1305 EP - 1311 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 35 IS - 12 N2 - The present study was undertaken to evaluate the effect of diallylsulphide (DAS) against mercuric chloride (HgCl2)-induced oxidative stress in rat livers. Rats were randomly divided into four groups of six rats each and exposed to HgCl2 (50 mg/kg/body weight (b.w.)) intraperitoneally and/or DAS (200 mg/kg/b.w.) by gavage. HgCl2 administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels (p < 0.05) with reduction in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). However, treatment with DAS markedly attenuated HgCl2-induced biochemical alterations in liver and serum transaminases (AST and ALT; p < 0.05). Further, biochemical results were confirmed by histopathological changes as compared to HgCl2-intoxicated rats. Histopathology of liver also showed that administration of DAS significantly reduced the damage generated by HgCl2 The present study suggests that DAS shows antioxidant activity and plays a protective role against mercury-induced oxidative damage in the rat livers. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/26825963/Protective_effect_of_diallylsulphide_against_mercuric_chloride_induced_hepatic_injury_in_rats_ L2 - http://journals.sagepub.com/doi/full/10.1177/0960327116629723?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -