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Prevalence of Mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in Tel Aviv: a prospective study.
Int J STD AIDS 2017; 28(2):127-132IJ

Abstract

We sought to investigate the prevalence of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis in men presenting to a sexually transmitted infection (STI) clinic, with special attention to M. genitalium, its occurrence in Israeli patients, coinfections, and risk factors. In a cross-sectional study, 259 men were successively enrolled in the Tel Aviv Levinsky Clinic for STIs between November 2008 and November 2010. There were 118 men with urethritis and 141 high-risk men without symptoms. M. genitalium, C. trachomatis, N. gonorrhoeae, and T. vaginalis were detected using nucleic acid amplification tests. Demographic characteristics and risk factors were documented. The overall prevalence of infection with M. genitalium, C. trachomatis, N. gonorrhoeae, and T. vaginalis, were 6.6%, 12.7%, 23.1%, and 0%, respectively. Prevalences in men with urethritis were 11.9%, 22%, and 49%, for M. genitalium, C. trachomatis, and N. gonorrhoeae, respectively. Prevalences in men without symptoms were 2.1%, 5.0%, and 1.4%, for M. genitalium, C. trachomatis, and N. gonorrhoeae, respectively. Co-infections were found only in symptomatic individuals, in whom 5.9% were infected concomitantly with C. trachomatis and N. gonorrhoeae, and 2.5% had dual infection with M. genitalium and N. gonorrhoeae. N. gonorrhoeae, C. trachomatis, and M. genitalium were significantly more prevalent in patients with urethritis. M. genitalium was significantly more prevalent in the heterosexual population than in homosexual males. To conclude, we have found that M. genitalium infection is associated with urethritis in Israeli men, and more so in the heterosexual population. Testing men for M. genitalium as a cause of non-gonococcal urethritis is warranted, particularly because of its poor response to doxycycline and possible failure of azithromycin.

Authors+Show Affiliations

1 Infectious Diseases Unit, E. Wolfson Hospital, Holon, Israel. 2 Levinsky STD Clinic, Ministry of Health, Tel Aviv, Israel.1 Infectious Diseases Unit, E. Wolfson Hospital, Holon, Israel. 2 Levinsky STD Clinic, Ministry of Health, Tel Aviv, Israel.3 Department of Clinical Microbiology, Chlamydia and Mycoplasma National Center, Rabin Medical Center, Petach Tikva, Israel. 4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.3 Department of Clinical Microbiology, Chlamydia and Mycoplasma National Center, Rabin Medical Center, Petach Tikva, Israel.1 Infectious Diseases Unit, E. Wolfson Hospital, Holon, Israel. 4 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26826161

Citation

Gottesman, Tamar, et al. "Prevalence of Mycoplasma Genitalium in Men With Urethritis and in High Risk Asymptomatic Males in Tel Aviv: a Prospective Study." International Journal of STD & AIDS, vol. 28, no. 2, 2017, pp. 127-132.
Gottesman T, Yossepowitch O, Samra Z, et al. Prevalence of Mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in Tel Aviv: a prospective study. Int J STD AIDS. 2017;28(2):127-132.
Gottesman, T., Yossepowitch, O., Samra, Z., Rosenberg, S., & Dan, M. (2017). Prevalence of Mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in Tel Aviv: a prospective study. International Journal of STD & AIDS, 28(2), pp. 127-132. doi:10.1177/0956462416630675.
Gottesman T, et al. Prevalence of Mycoplasma Genitalium in Men With Urethritis and in High Risk Asymptomatic Males in Tel Aviv: a Prospective Study. Int J STD AIDS. 2017;28(2):127-132. PubMed PMID: 26826161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in Tel Aviv: a prospective study. AU - Gottesman,Tamar, AU - Yossepowitch,Orit, AU - Samra,Zmira, AU - Rosenberg,Shoshana, AU - Dan,Michael, Y1 - 2016/07/10/ PY - 2016/1/31/pubmed PY - 2017/7/18/medline PY - 2016/1/31/entrez KW - Chlamydia trachomatis KW - Mycoplasma genitalium KW - Neisseria gonorrhoeae KW - Trichomonas vaginalis KW - Urethritis KW - homosexual men KW - nucleic acid amplification tests KW - sexually transmitted infection SP - 127 EP - 132 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 28 IS - 2 N2 - We sought to investigate the prevalence of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis in men presenting to a sexually transmitted infection (STI) clinic, with special attention to M. genitalium, its occurrence in Israeli patients, coinfections, and risk factors. In a cross-sectional study, 259 men were successively enrolled in the Tel Aviv Levinsky Clinic for STIs between November 2008 and November 2010. There were 118 men with urethritis and 141 high-risk men without symptoms. M. genitalium, C. trachomatis, N. gonorrhoeae, and T. vaginalis were detected using nucleic acid amplification tests. Demographic characteristics and risk factors were documented. The overall prevalence of infection with M. genitalium, C. trachomatis, N. gonorrhoeae, and T. vaginalis, were 6.6%, 12.7%, 23.1%, and 0%, respectively. Prevalences in men with urethritis were 11.9%, 22%, and 49%, for M. genitalium, C. trachomatis, and N. gonorrhoeae, respectively. Prevalences in men without symptoms were 2.1%, 5.0%, and 1.4%, for M. genitalium, C. trachomatis, and N. gonorrhoeae, respectively. Co-infections were found only in symptomatic individuals, in whom 5.9% were infected concomitantly with C. trachomatis and N. gonorrhoeae, and 2.5% had dual infection with M. genitalium and N. gonorrhoeae. N. gonorrhoeae, C. trachomatis, and M. genitalium were significantly more prevalent in patients with urethritis. M. genitalium was significantly more prevalent in the heterosexual population than in homosexual males. To conclude, we have found that M. genitalium infection is associated with urethritis in Israeli men, and more so in the heterosexual population. Testing men for M. genitalium as a cause of non-gonococcal urethritis is warranted, particularly because of its poor response to doxycycline and possible failure of azithromycin. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/26826161/Prevalence_of_Mycoplasma_genitalium_in_men_with_urethritis_and_in_high_risk_asymptomatic_males_in_Tel_Aviv:_a_prospective_study_ L2 - http://journals.sagepub.com/doi/full/10.1177/0956462416630675?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -