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Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics.
Trends Parasitol. 2016 Mar; 32(3):230-241.TP

Abstract

Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low and cannot account for the catastrophic epidemics of Gambian HAT (gHAT) seen over the past century. Here we examine the origins of gHAT epidemics and evidence implicating human genetics in HAT epidemiology. We discuss the role of stress causing breakdown of heritable tolerance in silent disease carriers generating gHAT outbreaks and see how peculiarities in the epidemiologies of gHAT and Rhodesian HAT (rHAT) impact on strategies for disease control.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Welburn SC
Centre for Infectious Diseases, Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address: Sue.Welburn@ed.ac.uk.
Molyneux DH
Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.
Maudlin I
Centre for Infectious Diseases, Edinburgh Medical School, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK.

MeSH

Africa South of the SaharaAnimalsDisease OutbreaksHumansResearchTrypanosomiasis, AfricanTsetse Flies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26826783

Citation

Welburn, Susan C., et al. "Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics." Trends in Parasitology, vol. 32, no. 3, 2016, pp. 230-241.
Welburn SC, Molyneux DH, Maudlin I. Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics. Trends Parasitol. 2016;32(3):230-241.
Welburn, S. C., Molyneux, D. H., & Maudlin, I. (2016). Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics. Trends in Parasitology, 32(3), 230-241. https://doi.org/10.1016/j.pt.2015.11.008
Welburn SC, Molyneux DH, Maudlin I. Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics. Trends Parasitol. 2016;32(3):230-241. PubMed PMID: 26826783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics. AU - Welburn,Susan C, AU - Molyneux,David H, AU - Maudlin,Ian, Y1 - 2016/01/27/ PY - 2015/10/06/received PY - 2015/11/02/revised PY - 2015/11/13/accepted PY - 2016/2/1/entrez PY - 2016/2/2/pubmed PY - 2016/7/29/medline KW - HAT KW - epidemics KW - epigenetics KW - famine KW - sleeping sickness KW - tsetse SP - 230 EP - 241 JF - Trends in parasitology JO - Trends Parasitol VL - 32 IS - 3 N2 - Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low and cannot account for the catastrophic epidemics of Gambian HAT (gHAT) seen over the past century. Here we examine the origins of gHAT epidemics and evidence implicating human genetics in HAT epidemiology. We discuss the role of stress causing breakdown of heritable tolerance in silent disease carriers generating gHAT outbreaks and see how peculiarities in the epidemiologies of gHAT and Rhodesian HAT (rHAT) impact on strategies for disease control. SN - 1471-5007 UR - https://www.unboundmedicine.com/medline/citation/26826783/Beyond_Tsetse__Implications_for_Research_and_Control_of_Human_African_Trypanosomiasis_Epidemics_ DB - PRIME DP - Unbound Medicine ER -