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Mimivirus inaugurated in the 21st century the beginning of a reclassification of viruses.
Curr Opin Microbiol. 2016 06; 31:16-24.CO

Abstract

Mimivirus and other giant viruses are visible by light microscopy and bona fide microbes that differ from other viruses and from cells that have a ribosome. They can be defined by: giant virion and genome sizes; their complexity, with the presence of DNA and mRNAs and dozens or hundreds of proteins in virions; the presence of translation-associated components; a mobilome including (pro)virophages (and a defence mechanism, named MIMIVIRE, against them) and transpovirons; their monophyly; the presence of the most archaic protein motifs they share with cellular organisms but not other viruses; a broader host range than other viruses. These features show that giant viruses are specific, autonomous, biological entities that warrant the creation of a new branch of microbes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sharma V
Aix-Marseille Univ., Ecole Centrale de Marseille, I2M UMR 7373, CNRS équipe Evolution Biologique et Modélisation, Marseille, France.
Colson P
IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
Pontarotti P
Aix-Marseille Univ., Ecole Centrale de Marseille, I2M UMR 7373, CNRS équipe Evolution Biologique et Modélisation, Marseille, France.
Raoult D
IHU Méditerranée Infection, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalo-Universitaire Timone, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; Aix-Marseille Univ., URMITE UM 63 CNRS 7278 IRD 198 INSERM U1095, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. Electronic address: didier.raoult@gmail.com.

MeSH

AcanthamoebaBiological EvolutionDNA, ViralGenome, ViralGiant VirusesMimiviridae

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26829206

Citation

Sharma, Vikas, et al. "Mimivirus Inaugurated in the 21st Century the Beginning of a Reclassification of Viruses." Current Opinion in Microbiology, vol. 31, 2016, pp. 16-24.
Sharma V, Colson P, Pontarotti P, et al. Mimivirus inaugurated in the 21st century the beginning of a reclassification of viruses. Curr Opin Microbiol. 2016;31:16-24.
Sharma, V., Colson, P., Pontarotti, P., & Raoult, D. (2016). Mimivirus inaugurated in the 21st century the beginning of a reclassification of viruses. Current Opinion in Microbiology, 31, 16-24. https://doi.org/10.1016/j.mib.2015.12.010
Sharma V, et al. Mimivirus Inaugurated in the 21st Century the Beginning of a Reclassification of Viruses. Curr Opin Microbiol. 2016;31:16-24. PubMed PMID: 26829206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mimivirus inaugurated in the 21st century the beginning of a reclassification of viruses. AU - Sharma,Vikas, AU - Colson,Philippe, AU - Pontarotti,Pierre, AU - Raoult,Didier, Y1 - 2016/01/30/ PY - 2015/11/30/received PY - 2015/12/22/revised PY - 2015/12/28/accepted PY - 2016/2/2/entrez PY - 2016/2/2/pubmed PY - 2017/11/29/medline SP - 16 EP - 24 JF - Current opinion in microbiology JO - Curr Opin Microbiol VL - 31 N2 - Mimivirus and other giant viruses are visible by light microscopy and bona fide microbes that differ from other viruses and from cells that have a ribosome. They can be defined by: giant virion and genome sizes; their complexity, with the presence of DNA and mRNAs and dozens or hundreds of proteins in virions; the presence of translation-associated components; a mobilome including (pro)virophages (and a defence mechanism, named MIMIVIRE, against them) and transpovirons; their monophyly; the presence of the most archaic protein motifs they share with cellular organisms but not other viruses; a broader host range than other viruses. These features show that giant viruses are specific, autonomous, biological entities that warrant the creation of a new branch of microbes. SN - 1879-0364 UR - https://www.unboundmedicine.com/medline/citation/26829206/Mimivirus_inaugurated_in_the_21st_century_the_beginning_of_a_reclassification_of_viruses_ DB - PRIME DP - Unbound Medicine ER -