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Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort.
Int J Cancer 2016; 138(12):2846-55IJ

Abstract

While dietary lycopene and tomato products have been inversely associated with prostate cancer incidence, there is limited evidence for an association between consumption of lycopene and tomato products and prostate-cancer specific mortality (PCSM). We examined the associations of prediagnosis and postdiagnosis dietary lycopene and tomato product intake with PCSM in a large prospective cohort. This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study II Nutrition Cohort in 1992 or 1993 and June 2011. Prediagnosis dietary data, collected at baseline, were available for 8,898 men, of whom 526 died of prostate cancer through 2012. Postdiagnosis dietary data, collected on follow-up surveys in 1999 and/or 2003, were available for 5,643 men, of whom 363 died of prostate cancer through 2012. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for PCSM. Neither prediagnosis nor postdiagnosis dietary lycopene intake was associated with PCSM (fourth vs. first quartile HR = 1.00, 95% CI 0.78-1.28; HR = 1.22, 95% CI 0.91-1.64, respectively). Similarly, neither prediagnosis nor postdiagnosis consumption of tomato products was associated with PCSM. Among men with high-risk cancers (T3-T4 or Gleason score 8-10, or nodal involvement), consistently reporting lycopene intake ≥ median on both postdiagnosis surveys was associated with lower PCSM (HR = 0.41, 95% CI 0.17-0.99, based on ten PCSM cases consistently ≥ median intake) compared to consistently reporting intake < median. Future studies are needed to confirm the potential inverse association of consistently high lycopene intake with PCSM among men with high-risk prostate cancers.

Authors+Show Affiliations

Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.Epidemiology Research Program, American Cancer Society, Atlanta, GA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26830232

Citation

Wang, Ying, et al. "Lycopene, Tomato Products and Prostate Cancer-specific Mortality Among Men Diagnosed With Nonmetastatic Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort." International Journal of Cancer, vol. 138, no. 12, 2016, pp. 2846-55.
Wang Y, Jacobs EJ, Newton CC, et al. Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Int J Cancer. 2016;138(12):2846-55.
Wang, Y., Jacobs, E. J., Newton, C. C., & McCullough, M. L. (2016). Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. International Journal of Cancer, 138(12), pp. 2846-55. doi:10.1002/ijc.30027.
Wang Y, et al. Lycopene, Tomato Products and Prostate Cancer-specific Mortality Among Men Diagnosed With Nonmetastatic Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort. Int J Cancer. 2016 Jun 15;138(12):2846-55. PubMed PMID: 26830232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. AU - Wang,Ying, AU - Jacobs,Eric J, AU - Newton,Christina C, AU - McCullough,Marjorie L, Y1 - 2016/02/23/ PY - 2015/09/25/received PY - 2016/01/04/revised PY - 2016/01/19/accepted PY - 2016/2/3/entrez PY - 2016/2/3/pubmed PY - 2016/8/19/medline KW - lycopene KW - mortality KW - prostate cancer KW - survival KW - tomato SP - 2846 EP - 55 JF - International journal of cancer JO - Int. J. Cancer VL - 138 IS - 12 N2 - While dietary lycopene and tomato products have been inversely associated with prostate cancer incidence, there is limited evidence for an association between consumption of lycopene and tomato products and prostate-cancer specific mortality (PCSM). We examined the associations of prediagnosis and postdiagnosis dietary lycopene and tomato product intake with PCSM in a large prospective cohort. This analysis included men diagnosed with nonmetastatic prostate cancer between enrollment in the Cancer Prevention Study II Nutrition Cohort in 1992 or 1993 and June 2011. Prediagnosis dietary data, collected at baseline, were available for 8,898 men, of whom 526 died of prostate cancer through 2012. Postdiagnosis dietary data, collected on follow-up surveys in 1999 and/or 2003, were available for 5,643 men, of whom 363 died of prostate cancer through 2012. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for PCSM. Neither prediagnosis nor postdiagnosis dietary lycopene intake was associated with PCSM (fourth vs. first quartile HR = 1.00, 95% CI 0.78-1.28; HR = 1.22, 95% CI 0.91-1.64, respectively). Similarly, neither prediagnosis nor postdiagnosis consumption of tomato products was associated with PCSM. Among men with high-risk cancers (T3-T4 or Gleason score 8-10, or nodal involvement), consistently reporting lycopene intake ≥ median on both postdiagnosis surveys was associated with lower PCSM (HR = 0.41, 95% CI 0.17-0.99, based on ten PCSM cases consistently ≥ median intake) compared to consistently reporting intake < median. Future studies are needed to confirm the potential inverse association of consistently high lycopene intake with PCSM among men with high-risk prostate cancers. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26830232/Lycopene_tomato_products_and_prostate_cancer_specific_mortality_among_men_diagnosed_with_nonmetastatic_prostate_cancer_in_the_Cancer_Prevention_Study_II_Nutrition_Cohort_ L2 - https://doi.org/10.1002/ijc.30027 DB - PRIME DP - Unbound Medicine ER -