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Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease.
J Alzheimers Dis. 2016; 50(4):1181-9.JA

Abstract

Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the systemic ceruloplasmin status in relation to copper is an emerging issue. To deepen this matter, we evaluated levels of ceruloplasmin concentration, ceruloplasmin activity, ceruloplasmin specific activity (eCp/iCp), copper, non-ceruloplasmin copper iron, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype in a sample of 84 AD patients and 58 healthy volunteers. From the univariate logistic analyses we found that ceruloplasmin concentration, eCp/iCp, copper, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype were significantly associated with the probability of AD. In the multivariable logistic regression analysis, we selected the best subset of biological predictors by the forward stepwise procedure. The analysis showed a decrease of the risk of having AD for eCp/iCp (p = 0.001) and an increase of this risk for non-ceruloplasmin copper (p = 0.008), age (p = 0.001), and APOE-ɛ4 allele (p < 0.001). The estimated model showed a good power in discriminating AD patients from healthy controls (area under curve: 88% ; sensitivity: 66% ; specificity 93%). These data strength the breakdown of copper homeostasis and propose eCp/iCp as a reliable marker of ceruloplasmin status.

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Authors+Show Affiliations

Siotto M
Don Carlo Gnocchi Foundation ONLUS, Milan, Italy.
Simonelli I
Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy.
Pasqualetti P
Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy.
Mariani S
Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy.
Caprara D
Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy.
Bucossi S
Institute of Neurology, Department of Geriatrics, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli, Rome, Italy.
Ventriglia M
Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy. Istituto di Scienze e Tecnologie della Cognizione (ISTC) - CNR, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.
Molinario R
Department of Diagnostic and Laboratory Medicine, Catholic University, Policlinic A. Gemelli, Rome, Italy.
Antenucci M
Department of Diagnostic and Laboratory Medicine, Catholic University, Policlinic A. Gemelli, Rome, Italy.
Rongioletti M
Molecular Biology Unit, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.
Rossini PM
Institute of Neurology, Department of Geriatrics, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli, Rome, Italy. Laboratory of Neurodegeneration, IRCSS "San Raffaele Pisana", Rome, Italy.
Squitti R
Fatebenefratelli Foundation for Health Research and Education, AFaR Division, Rome, Italy. Istituto di Scienze e Tecnologie della Cognizione (ISTC) - CNR, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.

MeSH

AgedAlzheimer DiseaseApolipoprotein E4Area Under CurveBiomarkersBlood Chemical AnalysisCeruloplasminCopperFemaleGenotypeGenotyping TechniquesHumansLogistic ModelsMaleMultivariate AnalysisPrognosisROC CurveRiskSensitivity and SpecificityTransferrin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26836154

Citation

Siotto, Mariacristina, et al. "Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 50, no. 4, 2016, pp. 1181-9.
Siotto M, Simonelli I, Pasqualetti P, et al. Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease. J Alzheimers Dis. 2016;50(4):1181-9.
Siotto, M., Simonelli, I., Pasqualetti, P., Mariani, S., Caprara, D., Bucossi, S., Ventriglia, M., Molinario, R., Antenucci, M., Rongioletti, M., Rossini, P. M., & Squitti, R. (2016). Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease. Journal of Alzheimer's Disease : JAD, 50(4), 1181-9. https://doi.org/10.3233/JAD-150611
Siotto M, et al. Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease. J Alzheimers Dis. 2016;50(4):1181-9. PubMed PMID: 26836154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Serum Ceruloplasmin Specific Activity and Risk of Alzheimer's Disease. AU - Siotto,Mariacristina, AU - Simonelli,Ilaria, AU - Pasqualetti,Patrizio, AU - Mariani,Stefania, AU - Caprara,Deborah, AU - Bucossi,Serena, AU - Ventriglia,Mariacarla, AU - Molinario,Rossana, AU - Antenucci,Mirca, AU - Rongioletti,Mauro, AU - Rossini,Paolo Maria, AU - Squitti,Rosanna, PY - 2016/2/3/entrez PY - 2016/2/3/pubmed PY - 2016/12/15/medline KW - Alzheimer’s disease KW - ceruloplasmin KW - ceruloplasmin specific activity KW - non-ceruloplasmin copper SP - 1181 EP - 9 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 50 IS - 4 N2 - Meta-analyses demonstrate copper involvement in Alzheimer's disease (AD), and the systemic ceruloplasmin status in relation to copper is an emerging issue. To deepen this matter, we evaluated levels of ceruloplasmin concentration, ceruloplasmin activity, ceruloplasmin specific activity (eCp/iCp), copper, non-ceruloplasmin copper iron, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype in a sample of 84 AD patients and 58 healthy volunteers. From the univariate logistic analyses we found that ceruloplasmin concentration, eCp/iCp, copper, transferrin, the ceruloplasmin/transferrin ratio, and the APOE genotype were significantly associated with the probability of AD. In the multivariable logistic regression analysis, we selected the best subset of biological predictors by the forward stepwise procedure. The analysis showed a decrease of the risk of having AD for eCp/iCp (p = 0.001) and an increase of this risk for non-ceruloplasmin copper (p = 0.008), age (p = 0.001), and APOE-ɛ4 allele (p < 0.001). The estimated model showed a good power in discriminating AD patients from healthy controls (area under curve: 88% ; sensitivity: 66% ; specificity 93%). These data strength the breakdown of copper homeostasis and propose eCp/iCp as a reliable marker of ceruloplasmin status. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26836154/Association_Between_Serum_Ceruloplasmin_Specific_Activity_and_Risk_of_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -