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Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children.

Abstract

RATIONALE

Allergen exposure is associated with the development of allergic sensitization in childhood as reflected by global variations in sensitization patterns. However, there is little evidence to support a direct association.

OBJECTIVES

To investigate the association between perinatal aeroallergen exposure and sensitization and rhinitis to such allergens later in childhood.

METHODS

Allergic sensitization to cat, dog, and house dust mites was diagnosed longitudinally using skin prick tests and specific IgE measurements at ½, 1½, 4, 6, and 13 years in 399 children from the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort. Rhinitis was diagnosed at 7 and 13 years. Allergen exposure was defined as dog or cat in the home during the 3rd trimester of pregnancy or the first year of life and as allergen levels of dog, cat, and house dust mite in bed dust samples at 1 year. Associations between exposure and outcomes were analyzed by logistic regression and stratified for eczema status and test method (skin prick test and specific IgE).

RESULTS

We found no association between dog or cat exposure in perinatal life and sensitization or rhinitis during childhood. Similarly, there was no association between levels of allergens in bed dust samples and sensitization or rhinitis during childhood.

CONCLUSION

Perinatal indoor aeroallergen exposure does not seem to affect development of allergic sensitization or rhinitis during childhood questioning the relevance of allergen avoidance as a preventive measure. Other factors such as timing of allergen exposure or other environmental adjuvants may contribute in a more complex pathway to sensitization.

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  • Authors+Show Affiliations

    ,

    COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

    ,

    COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

    ,

    COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

    ,

    Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

    COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

    Source

    Allergy 71:5 2016 05 pg 684-91

    MeSH

    Adolescent
    Air Pollution, Indoor
    Allergens
    Animals
    Cats
    Child
    Child, Preschool
    Comorbidity
    Dogs
    Environmental Exposure
    Female
    Humans
    Immunization
    Immunoglobulin E
    Infant
    Infant, Newborn
    Male
    Odds Ratio
    Patient Outcome Assessment
    Prospective Studies
    Pyroglyphidae
    Rhinitis, Allergic
    Risk
    Socioeconomic Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26836471

    Citation

    Schoos, A-M M., et al. "Early Indoor Aeroallergen Exposure Is Not Associated With Development of Sensitization or Allergic Rhinitis in High-risk Children." Allergy, vol. 71, no. 5, 2016, pp. 684-91.
    Schoos AM, Chawes BL, Jelding-Dannemand E, et al. Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children. Allergy. 2016;71(5):684-91.
    Schoos, A. M., Chawes, B. L., Jelding-Dannemand, E., Elfman, L. B., & Bisgaard, H. (2016). Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children. Allergy, 71(5), pp. 684-91. doi:10.1111/all.12853.
    Schoos AM, et al. Early Indoor Aeroallergen Exposure Is Not Associated With Development of Sensitization or Allergic Rhinitis in High-risk Children. Allergy. 2016;71(5):684-91. PubMed PMID: 26836471.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children. AU - Schoos,A-M M, AU - Chawes,B L, AU - Jelding-Dannemand,E, AU - Elfman,L B, AU - Bisgaard,H, Y1 - 2016/03/02/ PY - 2016/01/26/accepted PY - 2016/2/3/entrez PY - 2016/2/3/pubmed PY - 2017/11/29/medline KW - allergens KW - allergic rhinitis KW - children KW - dust samples KW - sensitization SP - 684 EP - 91 JF - Allergy JO - Allergy VL - 71 IS - 5 N2 - RATIONALE: Allergen exposure is associated with the development of allergic sensitization in childhood as reflected by global variations in sensitization patterns. However, there is little evidence to support a direct association. OBJECTIVES: To investigate the association between perinatal aeroallergen exposure and sensitization and rhinitis to such allergens later in childhood. METHODS: Allergic sensitization to cat, dog, and house dust mites was diagnosed longitudinally using skin prick tests and specific IgE measurements at ½, 1½, 4, 6, and 13 years in 399 children from the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort. Rhinitis was diagnosed at 7 and 13 years. Allergen exposure was defined as dog or cat in the home during the 3rd trimester of pregnancy or the first year of life and as allergen levels of dog, cat, and house dust mite in bed dust samples at 1 year. Associations between exposure and outcomes were analyzed by logistic regression and stratified for eczema status and test method (skin prick test and specific IgE). RESULTS: We found no association between dog or cat exposure in perinatal life and sensitization or rhinitis during childhood. Similarly, there was no association between levels of allergens in bed dust samples and sensitization or rhinitis during childhood. CONCLUSION: Perinatal indoor aeroallergen exposure does not seem to affect development of allergic sensitization or rhinitis during childhood questioning the relevance of allergen avoidance as a preventive measure. Other factors such as timing of allergen exposure or other environmental adjuvants may contribute in a more complex pathway to sensitization. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26836471/Early_indoor_aeroallergen_exposure_is_not_associated_with_development_of_sensitization_or_allergic_rhinitis_in_high_risk_children_ L2 - https://doi.org/10.1111/all.12853 DB - PRIME DP - Unbound Medicine ER -