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Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects on Sleep Quality.
Urol Int. 2016; 96(4):438-42.UI

Abstract

BACKGROUND

We investigated the efficacy of desmopressin in elderly patients with nocturnal polyuria (NP) to evaluate its effects on sleep quality.

METHODS

Patients with NP (defined as the nighttime urine production >33% of total 24-hour urine volume determined from a frequency-volume chart) were recruited. Desmopressin (0.2 mg) was treated orally at bedtime for 12 weeks. The participants completed the Medical Outcomes Study (MOS) Sleep Scale.

RESULTS

The mean patient age was 62.7 ± 13.0 (range 42-78 years). The mean symptom duration was 42.2 ± 39.7 months. The number of nocturia episodes (from 3.49 ± 1.83 to 2.03 ± 1.35, p = 0.01), nocturnal urine volume (p = 0.01), NP index (p = 0.01), and nocturia index (p = 0.01) decreased significantly after treatment with desmopressin. Among the MOS Sleep Scale categories, hours slept/night (p = 0.042), shortness of breath (p = 0.019), and adequacy of sleep (p = 0.001) changed significantly with a decrease in the number of nocturia episodes. Adverse events were mild.

CONCLUSIONS

Desmopressin is an effective treatment for NP and improved sleep quality in elderly men.

Authors+Show Affiliations

Department of Urology, Chonnam National University Medical School, Gwangju, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

26836495

Citation

Kim, Sun-Ouck, et al. "Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects On Sleep Quality." Urologia Internationalis, vol. 96, no. 4, 2016, pp. 438-42.
Kim SO, Yu HS, Kwon D. Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects on Sleep Quality. Urol Int. 2016;96(4):438-42.
Kim, S. O., Yu, H. S., & Kwon, D. (2016). Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects on Sleep Quality. Urologia Internationalis, 96(4), 438-42. https://doi.org/10.1159/000443968
Kim SO, Yu HS, Kwon D. Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects On Sleep Quality. Urol Int. 2016;96(4):438-42. PubMed PMID: 26836495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Desmopressin to Treat Nocturnal Polyuria in Elderly Men: Effects on Sleep Quality. AU - Kim,Sun-Ouck, AU - Yu,Ho Song, AU - Kwon,Dongdeuk, Y1 - 2016/02/03/ PY - 2015/10/27/received PY - 2016/01/11/accepted PY - 2016/2/3/entrez PY - 2016/2/3/pubmed PY - 2017/3/31/medline SP - 438 EP - 42 JF - Urologia internationalis JO - Urol Int VL - 96 IS - 4 N2 - BACKGROUND: We investigated the efficacy of desmopressin in elderly patients with nocturnal polyuria (NP) to evaluate its effects on sleep quality. METHODS: Patients with NP (defined as the nighttime urine production >33% of total 24-hour urine volume determined from a frequency-volume chart) were recruited. Desmopressin (0.2 mg) was treated orally at bedtime for 12 weeks. The participants completed the Medical Outcomes Study (MOS) Sleep Scale. RESULTS: The mean patient age was 62.7 ± 13.0 (range 42-78 years). The mean symptom duration was 42.2 ± 39.7 months. The number of nocturia episodes (from 3.49 ± 1.83 to 2.03 ± 1.35, p = 0.01), nocturnal urine volume (p = 0.01), NP index (p = 0.01), and nocturia index (p = 0.01) decreased significantly after treatment with desmopressin. Among the MOS Sleep Scale categories, hours slept/night (p = 0.042), shortness of breath (p = 0.019), and adequacy of sleep (p = 0.001) changed significantly with a decrease in the number of nocturia episodes. Adverse events were mild. CONCLUSIONS: Desmopressin is an effective treatment for NP and improved sleep quality in elderly men. SN - 1423-0399 UR - https://www.unboundmedicine.com/medline/citation/26836495/Efficacy_of_Desmopressin_to_Treat_Nocturnal_Polyuria_in_Elderly_Men:_Effects_on_Sleep_Quality_ L2 - https://www.karger.com?DOI=10.1159/000443968 DB - PRIME DP - Unbound Medicine ER -