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Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand.
Asian Pac J Cancer Prev. 2016; 17(1):341-5.AP

Abstract

BACKGROUND

Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population.

MATERIALS AND METHODS

A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations.

RESULTS

The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status.

CONCLUSIONS

This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

Authors+Show Affiliations

Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology, Nakhon-Ratchasima, Thailand E-mail : Taweesak.t@sut.ac.th.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26838234

Citation

Tongtawee, Taweesak, et al. "Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 17, no. 1, 2016, pp. 341-5.
Tongtawee T, Kaewpitoon S, Kaewpitoon N, et al. Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand. Asian Pac J Cancer Prev. 2016;17(1):341-5.
Tongtawee, T., Kaewpitoon, S., Kaewpitoon, N., Dechsukhum, C., Leeanansaksiri, W., Loyd, R. A., Matrakool, L., & Panpimanmas, S. (2016). Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand. Asian Pacific Journal of Cancer Prevention : APJCP, 17(1), 341-5.
Tongtawee T, et al. Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand. Asian Pac J Cancer Prev. 2016;17(1):341-5. PubMed PMID: 26838234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand. AU - Tongtawee,Taweesak, AU - Kaewpitoon,Soraya, AU - Kaewpitoon,Natthawut, AU - Dechsukhum,Chavaboon, AU - Leeanansaksiri,Wilairat, AU - Loyd,Ryan A, AU - Matrakool,Likit, AU - Panpimanmas,Sukij, PY - 2016/2/4/entrez PY - 2016/2/4/pubmed PY - 2016/11/12/medline SP - 341 EP - 5 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac J Cancer Prev VL - 17 IS - 1 N2 - BACKGROUND: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. MATERIALS AND METHODS: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. RESULTS: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. CONCLUSIONS: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/26838234/Helicobacter_Pylori_Associated_Gastritis_Increases_Risk_of_Colorectal_Polyps:_a_Hospital_Based_Cross_Sectional_Study_in_Nakhon_Ratchasima_Province_Northeastern_Thailand_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&amp;id=pmid:26838234&amp;key=2016.17.1.341 DB - PRIME DP - Unbound Medicine ER -