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Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection.
Talanta. 2016 Apr 01; 150:503-9.T

Abstract

Surface-Enhanced Raman scattering (SERS) has been widely used for imaging and sensing. However, limited reports are currently available on SERS-based cancer cell targeting strategy due to the challenge of synthesizing highly sensitive, reproducible and biocompatible SERS probe. Herein, we developed novel SERS probes, based on BSA (Bull Serum Albumin) coated gold-silver core-shell nanorods modified with Raman reporter 5,5-dithiobis 2-nitrobenzoic acid (DTNB) (Au@AgNRs@BSA@Anti-MICA), for in vitro cancer cell detection. Our results demonstrate that the SERS probe is very robust for cancer cell ultrasensitive detection with good biocompatibility and strong SERS signal.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yue J
Department of Spinal Cord Repairing, General Hospital of Jinan Military Area Command, Shifan Road 25, 250000 Jinan, Shandong, PR China.
Liu Z
Department of Oncology, Center Hospital of Feicheng Mining, 271600 Taian, Shandong, PR China.
Cai X
Department of Joint Motion, Center Hospital of Tengzhou, 277500 Shandong, PR China.
Ding X
School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
Chen S
School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China. Electronic address: chenshouhui1982@163.com.
Tao K
Department of Burn and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Changlexi Road 17, 710032 Xi'An, PR China. Electronic address: taokehopital@163.com.
Zhao T
Department of Spinal Cord Repairing, General Hospital of Jinan Military Area Command, Shifan Road 25, 250000 Jinan, Shandong, PR China. Electronic address: zhaotingbao1020@163.com.

MeSH

AnimalsBone NeoplasmsCattleCell ProliferationGoldHumansMaleMetal NanoparticlesNanotubesOsteosarcomaSerum Albumin, BovineSilverSpectrum Analysis, RamanTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26838436

Citation

Yue, Ji, et al. "Bull Serum Albumin Coated Au@Agnanorods as SERS Probes for Ultrasensitive Osteosarcoma Cell Detection." Talanta, vol. 150, 2016, pp. 503-9.
Yue J, Liu Z, Cai X, et al. Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection. Talanta. 2016;150:503-9.
Yue, J., Liu, Z., Cai, X., Ding, X., Chen, S., Tao, K., & Zhao, T. (2016). Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection. Talanta, 150, 503-9. https://doi.org/10.1016/j.talanta.2015.12.065
Yue J, et al. Bull Serum Albumin Coated Au@Agnanorods as SERS Probes for Ultrasensitive Osteosarcoma Cell Detection. Talanta. 2016 Apr 1;150:503-9. PubMed PMID: 26838436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection. AU - Yue,Ji, AU - Liu,Zhen, AU - Cai,Xingyu, AU - Ding,Xianting, AU - Chen,Shouhui, AU - Tao,Ke, AU - Zhao,Tingbao, Y1 - 2015/12/25/ PY - 2015/09/01/received PY - 2015/12/21/revised PY - 2015/12/24/accepted PY - 2016/2/4/entrez PY - 2016/2/4/pubmed PY - 2016/11/2/medline KW - Au@AgNRs@BSA KW - Cancer detection KW - Osteosarcoma KW - SERS SP - 503 EP - 9 JF - Talanta JO - Talanta VL - 150 N2 - Surface-Enhanced Raman scattering (SERS) has been widely used for imaging and sensing. However, limited reports are currently available on SERS-based cancer cell targeting strategy due to the challenge of synthesizing highly sensitive, reproducible and biocompatible SERS probe. Herein, we developed novel SERS probes, based on BSA (Bull Serum Albumin) coated gold-silver core-shell nanorods modified with Raman reporter 5,5-dithiobis 2-nitrobenzoic acid (DTNB) (Au@AgNRs@BSA@Anti-MICA), for in vitro cancer cell detection. Our results demonstrate that the SERS probe is very robust for cancer cell ultrasensitive detection with good biocompatibility and strong SERS signal. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/26838436/Bull_serum_albumin_coated_Au@Agnanorods_as_SERS_probes_for_ultrasensitive_osteosarcoma_cell_detection_ DB - PRIME DP - Unbound Medicine ER -