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Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment.
J Korean Med Sci. 2016 Feb; 31(2):286-95.JK

Abstract

This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) ε4 and beta-amyloid (Aβ) on multiple cognitive domains in a large group of cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Participants were included if clinical and cognitive assessments, amyloid imaging, and APOE genotype were all available from the Alzheimer's Disease Neuroimaging Initiative database (CN = 324, MCI = 502, AD = 182). Individuals with one or two copies of ε4 were designated as APOE ε4 carriers (ε4+); individuals with no ε4 were designated as APOE ε4 non-carriers (ε4-). Based on mean florbetapir standard uptake value ratios, participants were classified as Aβ burden-positive (Aβ+) or Aβ burden-negative (Aβ-). In MCI, APOE ε4 effects were predominantly observed on frontal executive function, with ε4+ participants exhibiting poorer performances; Aβ positivity had no influence on this effect. Aβ effects were observed on global cognition, memory, and visuospatial ability, with Aβ+ participants exhibiting poorer performances. Measures of frontal executive function were not influenced by Aβ. Interactive effects of APOE ε4+ and Aβ were observed on global cognition and verbal recognition memory. Aβ, not APOE ε4+, influenced clinical severity and functional status. The influences of APOE ε4+ and Aβ on cognitive function were minimal in CN and AD. In conclusion, we provide further evidence of both independent and interactive influences of APOE ε4+ and Aβ on cognitive function in MCI, with APOE ε4+ and Aβ showing dissociable effects on executive and non-executive functions, respectively.

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Authors+Show Affiliations

Seo EH
Premedical Science, College of Medicine, Chosun University, Gwangju, Korea.
Kim SH
Department of Neuropsychiatry, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea.
Park SH
Department of Neuropsychiatry, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea.
Kang SH
Department of Laboratory Medicine, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea.
Choo IH
Department of Neuropsychiatry, School of Medicine, Chosun University/Chosun University Hospital, Gwangju, Korea.
Alzheimer's Disease Neuroimaging Initiative
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsApolipoprotein E4BrainCognitionCognitive DysfunctionDatabases, FactualDemographyEthylene GlycolsFemaleGenotypeHumansMalePositron-Emission TomographyRadiography

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26839485

Citation

Seo, Eun Hyun, et al. "Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden On Cognitive Function in Mild Cognitive Impairment." Journal of Korean Medical Science, vol. 31, no. 2, 2016, pp. 286-95.
Seo EH, Kim SH, Park SH, et al. Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. J Korean Med Sci. 2016;31(2):286-95.
Seo, E. H., Kim, S. H., Park, S. H., Kang, S. H., & Choo, I. H. (2016). Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. Journal of Korean Medical Science, 31(2), 286-95. https://doi.org/10.3346/jkms.2016.31.2.286
Seo EH, et al. Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden On Cognitive Function in Mild Cognitive Impairment. J Korean Med Sci. 2016;31(2):286-95. PubMed PMID: 26839485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment. AU - Seo,Eun Hyun, AU - Kim,Sang Hoon, AU - Park,Sang Hag, AU - Kang,Seong-Ho, AU - Choo,Il Han, AU - ,, Y1 - 2016/01/13/ PY - 2015/07/16/received PY - 2015/11/09/accepted PY - 2016/2/4/entrez PY - 2016/2/4/pubmed PY - 2016/11/1/medline KW - APOE ε4+ KW - Alzheimer Disease KW - Beta-amyloid Burden KW - Mild Cognitive Impairment KW - Neuropsychology SP - 286 EP - 95 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 31 IS - 2 N2 - This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) ε4 and beta-amyloid (Aβ) on multiple cognitive domains in a large group of cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Participants were included if clinical and cognitive assessments, amyloid imaging, and APOE genotype were all available from the Alzheimer's Disease Neuroimaging Initiative database (CN = 324, MCI = 502, AD = 182). Individuals with one or two copies of ε4 were designated as APOE ε4 carriers (ε4+); individuals with no ε4 were designated as APOE ε4 non-carriers (ε4-). Based on mean florbetapir standard uptake value ratios, participants were classified as Aβ burden-positive (Aβ+) or Aβ burden-negative (Aβ-). In MCI, APOE ε4 effects were predominantly observed on frontal executive function, with ε4+ participants exhibiting poorer performances; Aβ positivity had no influence on this effect. Aβ effects were observed on global cognition, memory, and visuospatial ability, with Aβ+ participants exhibiting poorer performances. Measures of frontal executive function were not influenced by Aβ. Interactive effects of APOE ε4+ and Aβ were observed on global cognition and verbal recognition memory. Aβ, not APOE ε4+, influenced clinical severity and functional status. The influences of APOE ε4+ and Aβ on cognitive function were minimal in CN and AD. In conclusion, we provide further evidence of both independent and interactive influences of APOE ε4+ and Aβ on cognitive function in MCI, with APOE ε4+ and Aβ showing dissociable effects on executive and non-executive functions, respectively. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/26839485/Independent_and_Interactive_Influences_of_the_APOE_Genotype_and_Beta_Amyloid_Burden_on_Cognitive_Function_in_Mild_Cognitive_Impairment_ DB - PRIME DP - Unbound Medicine ER -