Tags

Type your tag names separated by a space and hit enter

Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

Abstract

Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

    ,

    College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.

    ,

    College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

    ,

    Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA; Robley Rex Veterans Affairs Medical Center, Louisville, KY 40202, USA.

    School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Departments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

    Source

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26839540

    Citation

    Li, Fengyuan, et al. "Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms." Gastroenterology Research and Practice, vol. 2016, 2016, p. 5491465.
    Li F, Duan K, Wang C, et al. Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. Gastroenterol Res Pract. 2016;2016:5491465.
    Li, F., Duan, K., Wang, C., McClain, C., & Feng, W. (2016). Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. Gastroenterology Research and Practice, 2016, p. 5491465. doi:10.1155/2016/5491465.
    Li F, et al. Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. Gastroenterol Res Pract. 2016;2016:5491465. PubMed PMID: 26839540.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms. AU - Li,Fengyuan, AU - Duan,Kangmin, AU - Wang,Cuiling, AU - McClain,Craig, AU - Feng,Wenke, Y1 - 2015/12/29/ PY - 2015/09/22/received PY - 2015/11/06/revised PY - 2015/11/08/accepted PY - 2016/2/4/entrez PY - 2016/2/4/pubmed PY - 2016/2/4/medline SP - 5491465 EP - 5491465 JF - Gastroenterology research and practice JO - Gastroenterol Res Pract VL - 2016 N2 - Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed. SN - 1687-6121 UR - https://www.unboundmedicine.com/medline/citation/26839540/full_citation L2 - https://dx.doi.org/10.1155/2016/5491465 DB - PRIME DP - Unbound Medicine ER -