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LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE.

Abstract

BACKGROUND

Inflammatory bowel disease, comprising Crohn's disease and ulcerative colitis, is a group of debilitating conditions associated with deregulated mucosal immune response. Vitamin D has been implicated in immune response and gastrointestinal function.

OBJECTIVES

To investigate the correlation between serum vitamin D levels and disease activity and quality of life in patients with inflammatory bowel disease.

METHODS

This cross-sectional study enrolled ambulatory patients with inflammatory bowel disease and assessed clinical disease activity and quality of life (Short Inflammatory Bowel Disease Questionnaire [SIBDQ]). Vitamin D levels were determined via serum 25-hydroxyvitamin D measurement; deficiency was defined as values <20 ng/mL. Statistical analysis was performed with SPSS vs 20.0.

RESULTS

A total of 76 patients were enrolled, 19 with ulcerative colitis (25%) and 57 with Crohn's disease (75%). Overall, mean serum 25-hydroxyvitamin D levels were low (26.0±10.0 ng/mL), while those in patients with Crohn's disease were significantly lower than ulcerative colitis (24.6±8.0 vs 30.0±12.5 ng/mL; P=0.032). Vitamin D deficiency was found in 30% of patients. Patients who were in clinical remission were found to have higher levels of vitamin D than those who were not in remission (28.0±10.3 vs 21.6±6.0 ng/mL, P=0.001). Inflammatory bowel disease patients with SIBDQ scores <50 were found to have significantly lower mean vitamin D levels compared with patients who had SIBDQ scores ≥50 (23.4±6.9 vs 27.9±10.8 ng/mL, P=0.041).

CONCLUSIONS

A high proportion of patients with inflammatory bowel disease were vitamin D deficient, particularly patients with Crohn's disease. Both clinical disease activity and quality of life correlated significantly with lower levels of vitamin D, illustrating a clear need for supplementation in patients with inflammatory bowel disease.

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  • Authors+Show Affiliations

    ,

    Departamento de Gastroenterologia, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    ,

    Departamento de Gastroenterologia, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    ,

    Departamento de Gastroenterologia, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    ,

    Departamento de Gastroenterologia, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    ,

    Departamento de Patologia Clínica, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    Departamento de Gastroenterologia, Centro Hospitalar do Alto Ave, Guimarães, Portugal.

    Source

    Arquivos de gastroenterologia 52:4 2015 Dec pg 260-5

    MeSH

    Adult
    Colitis, Ulcerative
    Crohn Disease
    Cross-Sectional Studies
    Female
    Humans
    Male
    Quality of Life
    Severity of Illness Index
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26840465

    Citation

    Castro, Francisca Dias De, et al. "LOWER LEVELS of VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY and QUALITY of LIFE in INFLAMMATORY BOWEL DISEASE." Arquivos De Gastroenterologia, vol. 52, no. 4, 2015, pp. 260-5.
    Castro FD, Magalhães J, Carvalho PB, et al. LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE. Arq Gastroenterol. 2015;52(4):260-5.
    Castro, F. D., Magalhães, J., Carvalho, P. B., Moreira, M. J., Mota, P., & Cotter, J. (2015). LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE. Arquivos De Gastroenterologia, 52(4), pp. 260-5. doi:10.1590/S0004-28032015000400003.
    Castro FD, et al. LOWER LEVELS of VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY and QUALITY of LIFE in INFLAMMATORY BOWEL DISEASE. Arq Gastroenterol. 2015;52(4):260-5. PubMed PMID: 26840465.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE. AU - Castro,Francisca Dias De, AU - Magalhães,Joana, AU - Carvalho,Pedro Boal, AU - Moreira,Maria João, AU - Mota,Paula, AU - Cotter,José, PY - 2014/06/06/received PY - 2015/09/08/accepted PY - 2016/2/4/entrez PY - 2016/2/4/pubmed PY - 2016/7/30/medline SP - 260 EP - 5 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 52 IS - 4 N2 - BACKGROUND: Inflammatory bowel disease, comprising Crohn's disease and ulcerative colitis, is a group of debilitating conditions associated with deregulated mucosal immune response. Vitamin D has been implicated in immune response and gastrointestinal function. OBJECTIVES: To investigate the correlation between serum vitamin D levels and disease activity and quality of life in patients with inflammatory bowel disease. METHODS: This cross-sectional study enrolled ambulatory patients with inflammatory bowel disease and assessed clinical disease activity and quality of life (Short Inflammatory Bowel Disease Questionnaire [SIBDQ]). Vitamin D levels were determined via serum 25-hydroxyvitamin D measurement; deficiency was defined as values <20 ng/mL. Statistical analysis was performed with SPSS vs 20.0. RESULTS: A total of 76 patients were enrolled, 19 with ulcerative colitis (25%) and 57 with Crohn's disease (75%). Overall, mean serum 25-hydroxyvitamin D levels were low (26.0±10.0 ng/mL), while those in patients with Crohn's disease were significantly lower than ulcerative colitis (24.6±8.0 vs 30.0±12.5 ng/mL; P=0.032). Vitamin D deficiency was found in 30% of patients. Patients who were in clinical remission were found to have higher levels of vitamin D than those who were not in remission (28.0±10.3 vs 21.6±6.0 ng/mL, P=0.001). Inflammatory bowel disease patients with SIBDQ scores <50 were found to have significantly lower mean vitamin D levels compared with patients who had SIBDQ scores ≥50 (23.4±6.9 vs 27.9±10.8 ng/mL, P=0.041). CONCLUSIONS: A high proportion of patients with inflammatory bowel disease were vitamin D deficient, particularly patients with Crohn's disease. Both clinical disease activity and quality of life correlated significantly with lower levels of vitamin D, illustrating a clear need for supplementation in patients with inflammatory bowel disease. SN - 1678-4219 UR - https://www.unboundmedicine.com/medline/citation/26840465/LOWER_LEVELS_OF_VITAMIN_D_CORRELATE_WITH_CLINICAL_DISEASE_ACTIVITY_AND_QUALITY_OF_LIFE_IN_INFLAMMATORY_BOWEL_DISEASE_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-28032015000400260&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -