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A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial.
Mol Nutr Food Res. 2016 05; 60(5):1099-109.MN

Abstract

SCOPE

This study evaluated the dose-response relationship of strawberries, an anthocyanin-rich fruit, on postprandial glucose and insulin concentrations in individuals with insulin resistance (IR), including changes in plasma anthocyanins, markers of oxidative stress, and inflammation.

METHODS AND RESULTS

In a randomized controlled, four-arm, dose-response, crossover trial, 21 adults with IR consumed a high-carbohydrate, high-fat meal with one of four beverages containing 0 g freeze-dried whole strawberry powder (0g FDS, control), 10, 20, or 40 g FDS, controlled for fiber. Blood was collected at 0 min and at 30 min intervals postmeal until 2 h, then hourly until 6 h. Postmeal insulin concentrations (6 h) were significantly reduced after the 40-g FDS beverage compared to other beverages (p < 0.05). Postmeal 6 h glucose concentrations were not different, although mean insulin:glucose ratio was significantly different among beverages (p < 0.05). Pelargonidin-glucuronide was inversely associated with mean insulin concentrations after the 20 and 40 g FDS (p < 0.05). Oxidized low-density lipoprotein was reduced after 20 g FDS (p < 0.05) and IL-6 was not different among treatments. Strawberry intake reduced the insulin demand to manage postmeal glucose in obese individuals with IR, which was related to plasma anthocyanin/pelargonidin concentrations.

CONCLUSION

The data support a role of strawberries in improving insulin sensitivity in people with IR.

Authors+Show Affiliations

Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA.Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL, USA. Department of Nutrition, University of California, Davis, CA, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26842771

Citation

Park, Eunyoung, et al. "A Dose-response Evaluation of Freeze-dried Strawberries Independent of Fiber Content On Metabolic Indices in Abdominally Obese Individuals With Insulin Resistance in a Randomized, Single-blinded, Diet-controlled Crossover Trial." Molecular Nutrition & Food Research, vol. 60, no. 5, 2016, pp. 1099-109.
Park E, Edirisinghe I, Wei H, et al. A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial. Mol Nutr Food Res. 2016;60(5):1099-109.
Park, E., Edirisinghe, I., Wei, H., Vijayakumar, L. P., Banaszewski, K., Cappozzo, J. C., & Burton-Freeman, B. (2016). A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial. Molecular Nutrition & Food Research, 60(5), 1099-109. https://doi.org/10.1002/mnfr.201500845
Park E, et al. A Dose-response Evaluation of Freeze-dried Strawberries Independent of Fiber Content On Metabolic Indices in Abdominally Obese Individuals With Insulin Resistance in a Randomized, Single-blinded, Diet-controlled Crossover Trial. Mol Nutr Food Res. 2016;60(5):1099-109. PubMed PMID: 26842771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial. AU - Park,Eunyoung, AU - Edirisinghe,Indika, AU - Wei,Hequn, AU - Vijayakumar,Lakshmi Prabha, AU - Banaszewski,Katarzyna, AU - Cappozzo,Jack C, AU - Burton-Freeman,Britt, Y1 - 2016/03/29/ PY - 2015/10/27/received PY - 2016/01/08/revised PY - 2016/01/11/accepted PY - 2016/2/5/entrez PY - 2016/2/5/pubmed PY - 2017/12/6/medline SP - 1099 EP - 109 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 60 IS - 5 N2 - SCOPE: This study evaluated the dose-response relationship of strawberries, an anthocyanin-rich fruit, on postprandial glucose and insulin concentrations in individuals with insulin resistance (IR), including changes in plasma anthocyanins, markers of oxidative stress, and inflammation. METHODS AND RESULTS: In a randomized controlled, four-arm, dose-response, crossover trial, 21 adults with IR consumed a high-carbohydrate, high-fat meal with one of four beverages containing 0 g freeze-dried whole strawberry powder (0g FDS, control), 10, 20, or 40 g FDS, controlled for fiber. Blood was collected at 0 min and at 30 min intervals postmeal until 2 h, then hourly until 6 h. Postmeal insulin concentrations (6 h) were significantly reduced after the 40-g FDS beverage compared to other beverages (p < 0.05). Postmeal 6 h glucose concentrations were not different, although mean insulin:glucose ratio was significantly different among beverages (p < 0.05). Pelargonidin-glucuronide was inversely associated with mean insulin concentrations after the 20 and 40 g FDS (p < 0.05). Oxidized low-density lipoprotein was reduced after 20 g FDS (p < 0.05) and IL-6 was not different among treatments. Strawberry intake reduced the insulin demand to manage postmeal glucose in obese individuals with IR, which was related to plasma anthocyanin/pelargonidin concentrations. CONCLUSION: The data support a role of strawberries in improving insulin sensitivity in people with IR. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/26842771/A_dose_response_evaluation_of_freeze_dried_strawberries_independent_of_fiber_content_on_metabolic_indices_in_abdominally_obese_individuals_with_insulin_resistance_in_a_randomized_single_blinded_diet_controlled_crossover_trial_ DB - PRIME DP - Unbound Medicine ER -