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Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis.
Am J Clin Nutr. 2016 Mar; 103(3):818-29.AJ

Abstract

BACKGROUND

Previous cohort studies have shown that moderate alcohol consumption was associated with a lower risk of type 2 diabetes (T2D). However, whether these associations differ according to the characteristics of patients with T2D remains controversial.

OBJECTIVE

The purpose of this study was to explore and summarize the evidence on the strength of the association between alcohol consumption and the subsequent risk of T2D by using a dose-response meta-analytic approach.

DESIGN

We identified potential studies by searching the PubMed, Embase, and Cochrane Library databases up to 24 March 2015. Prospective observational studies that evaluated the relation between alcohol consumption and the risk of T2D and reported its effect estimates with 95% CIs were included.

RESULTS

Analyses were based on 706,716 individuals (275,711 men and 431,005 women) from 26 studies with 31,621 T2D cases. We detected a nonlinear relation between alcohol consumption and the risk of T2D, which was identified in all cohorts (P-trend < 0.001, P-nonlinearity < 0.001), in men (P-trend < 0.001, P-nonlinearity < 0.001), and in women (P-trend < 0.001, P-nonlinearity < 0.001). Compared with the minimal category of alcohol consumption, light (RR: 0.83; 95% CI: 0.73, 0.95; P = 0.005) and moderate (RR: 0.74; 95% CI: 0.67, 0.82; P < 0.001) alcohol consumption was associated with a lower risk of T2D. However, heavy alcohol consumption had little or no effect on subsequent T2D risk. Furthermore, the summary RR ratio (RRR; male to female) of the comparison between moderate alcohol consumption and the minimal alcohol categories for T2D was significantly higher, and the pooled RRR (current smoker to never smoker) of light alcohol consumption was significantly reduced.

CONCLUSIONS

Light and moderate alcohol consumption was associated with a lower risk of T2D, whereas heavy alcohol consumption was not related to the risk of T2D.

Authors+Show Affiliations

Department of Endocrinology and.Department of Health Statistics, Second Military Medical University, Shanghai, China.Rehabilitation Institute, Shanghai Seventh People's Hospital, Shanghai, China; and zhou_ly@126.com hejia63@yahoo.com.Department of Health Statistics, Second Military Medical University, Shanghai, China zhou_ly@126.com hejia63@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26843157

Citation

Li, Xiao-Hua, et al. "Association Between Alcohol Consumption and the Risk of Incident Type 2 Diabetes: a Systematic Review and Dose-response Meta-analysis." The American Journal of Clinical Nutrition, vol. 103, no. 3, 2016, pp. 818-29.
Li XH, Yu FF, Zhou YH, et al. Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis. Am J Clin Nutr. 2016;103(3):818-29.
Li, X. H., Yu, F. F., Zhou, Y. H., & He, J. (2016). Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis. The American Journal of Clinical Nutrition, 103(3), 818-29. https://doi.org/10.3945/ajcn.115.114389
Li XH, et al. Association Between Alcohol Consumption and the Risk of Incident Type 2 Diabetes: a Systematic Review and Dose-response Meta-analysis. Am J Clin Nutr. 2016;103(3):818-29. PubMed PMID: 26843157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis. AU - Li,Xiao-Hua, AU - Yu,Fei-Fei, AU - Zhou,Yu-Hao, AU - He,Jia, Y1 - 2016/02/03/ PY - 2015/05/04/received PY - 2015/12/23/accepted PY - 2016/2/5/entrez PY - 2016/2/5/pubmed PY - 2016/7/9/medline KW - alcohol KW - dose-response KW - meta-analysis KW - systematic review KW - type 2 diabetes SP - 818 EP - 29 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 103 IS - 3 N2 - BACKGROUND: Previous cohort studies have shown that moderate alcohol consumption was associated with a lower risk of type 2 diabetes (T2D). However, whether these associations differ according to the characteristics of patients with T2D remains controversial. OBJECTIVE: The purpose of this study was to explore and summarize the evidence on the strength of the association between alcohol consumption and the subsequent risk of T2D by using a dose-response meta-analytic approach. DESIGN: We identified potential studies by searching the PubMed, Embase, and Cochrane Library databases up to 24 March 2015. Prospective observational studies that evaluated the relation between alcohol consumption and the risk of T2D and reported its effect estimates with 95% CIs were included. RESULTS: Analyses were based on 706,716 individuals (275,711 men and 431,005 women) from 26 studies with 31,621 T2D cases. We detected a nonlinear relation between alcohol consumption and the risk of T2D, which was identified in all cohorts (P-trend < 0.001, P-nonlinearity < 0.001), in men (P-trend < 0.001, P-nonlinearity < 0.001), and in women (P-trend < 0.001, P-nonlinearity < 0.001). Compared with the minimal category of alcohol consumption, light (RR: 0.83; 95% CI: 0.73, 0.95; P = 0.005) and moderate (RR: 0.74; 95% CI: 0.67, 0.82; P < 0.001) alcohol consumption was associated with a lower risk of T2D. However, heavy alcohol consumption had little or no effect on subsequent T2D risk. Furthermore, the summary RR ratio (RRR; male to female) of the comparison between moderate alcohol consumption and the minimal alcohol categories for T2D was significantly higher, and the pooled RRR (current smoker to never smoker) of light alcohol consumption was significantly reduced. CONCLUSIONS: Light and moderate alcohol consumption was associated with a lower risk of T2D, whereas heavy alcohol consumption was not related to the risk of T2D. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/26843157/Association_between_alcohol_consumption_and_the_risk_of_incident_type_2_diabetes:_a_systematic_review_and_dose_response_meta_analysis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.114389 DB - PRIME DP - Unbound Medicine ER -