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Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China.
Br J Nutr 2016; 115(6):960-6BJ

Abstract

Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). In the present study, we assessed serum 25OHD concentration and its association with PTH and BMD in urban males from Guiyang (N26.57°), the capital city of Guizhou province, Southwest China. We recruited 634 males aged >20 years from the Guiyang Health Measures Survey, and stratified them into three groups according to age: young (20-39 years), middle aged (40-59 years) and older (60-79 years). We measured serum concentrations of 25OHD, PTH levels and BMD of the lumbar spine (L1-L4), femoral neck and total hip. In addition, we also explored the relationship between 25OHD and lifestyle, socio-economic characteristics and medical history by applying covariance analysis and locally weighted regression plots. The results showed that serum 25OHD was 75 nmol/l in 12·6 % of the subjects. Higher level of serum PTH was detected in relation to lower concentrations of serum 25OHD up to 50 nmol/l. A negative correlation between serum 25OHD and PTH concentrations was observed (r -0·207, P=0·003). Mean concentration of serum PTH increased gradually and plateaued while concentrations of serum 25OHD decreased to 50 nmol/l. Gradual increase in serum PTH was observed as 25OHD concentration was <25 nmol/l (P=0·004). BMD values at all sites were greater in the higher serum 25OHD concentration group. This study shows that low concentrations of serum 25OHD were common in males, and bone health was likely to be improved when serum 25OHD values were between 30 and 50 nmol/l.

Authors+Show Affiliations

Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.Department of Endocrinology and Metabolism,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,People's Republic of China,China.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26843386

Citation

Zhang, Qiao, et al. "Serum Concentrations of 25-hydroxyvitamin D and Its Association With Bone Mineral Density and Serum Parathyroid Hormone Levels During Winter in Urban Males From Guiyang, Southwest China." The British Journal of Nutrition, vol. 115, no. 6, 2016, pp. 960-6.
Zhang Q, Shi L, Peng N, et al. Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China. Br J Nutr. 2016;115(6):960-6.
Zhang, Q., Shi, L., Peng, N., Xu, S., Zhang, M., Zhang, S., ... Wang, R. (2016). Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China. The British Journal of Nutrition, 115(6), pp. 960-6. doi:10.1017/S0007114515005383.
Zhang Q, et al. Serum Concentrations of 25-hydroxyvitamin D and Its Association With Bone Mineral Density and Serum Parathyroid Hormone Levels During Winter in Urban Males From Guiyang, Southwest China. Br J Nutr. 2016 Mar 28;115(6):960-6. PubMed PMID: 26843386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China. AU - Zhang,Qiao, AU - Shi,Lixin, AU - Peng,Nianchun, AU - Xu,Shujing, AU - Zhang,Miao, AU - Zhang,Song, AU - Li,Hong, AU - Zhuang,Huijun, AU - Gong,Mingxian, AU - Wu,Danrong, AU - Wang,Rui, Y1 - 2016/02/04/ PY - 2016/2/5/entrez PY - 2016/2/5/pubmed PY - 2016/7/22/medline KW - 25OHD 25-hydroxyvitamin D KW - Bone mineral density KW - Cr creatinine KW - PTH parathyroid hormone KW - Parathyroid hormone KW - Serum 25-hydroxyvitamin D KW - Southwest China SP - 960 EP - 6 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 6 N2 - Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). In the present study, we assessed serum 25OHD concentration and its association with PTH and BMD in urban males from Guiyang (N26.57°), the capital city of Guizhou province, Southwest China. We recruited 634 males aged >20 years from the Guiyang Health Measures Survey, and stratified them into three groups according to age: young (20-39 years), middle aged (40-59 years) and older (60-79 years). We measured serum concentrations of 25OHD, PTH levels and BMD of the lumbar spine (L1-L4), femoral neck and total hip. In addition, we also explored the relationship between 25OHD and lifestyle, socio-economic characteristics and medical history by applying covariance analysis and locally weighted regression plots. The results showed that serum 25OHD was 75 nmol/l in 12·6 % of the subjects. Higher level of serum PTH was detected in relation to lower concentrations of serum 25OHD up to 50 nmol/l. A negative correlation between serum 25OHD and PTH concentrations was observed (r -0·207, P=0·003). Mean concentration of serum PTH increased gradually and plateaued while concentrations of serum 25OHD decreased to 50 nmol/l. Gradual increase in serum PTH was observed as 25OHD concentration was <25 nmol/l (P=0·004). BMD values at all sites were greater in the higher serum 25OHD concentration group. This study shows that low concentrations of serum 25OHD were common in males, and bone health was likely to be improved when serum 25OHD values were between 30 and 50 nmol/l. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26843386/Serum_concentrations_of_25_hydroxyvitamin_D_and_its_association_with_bone_mineral_density_and_serum_parathyroid_hormone_levels_during_winter_in_urban_males_from_Guiyang_Southwest_China_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515005383/type/journal_article DB - PRIME DP - Unbound Medicine ER -