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The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts.
Brain Pathol. 2017 01; 27(1):77-85.BP

Abstract

The relationship of cerebral vessel pathology to brain microinfarcts is not fully understood. We examined associations of cerebral vessel pathology with microinfarcts among community-dwelling persons who came to autopsy. Brain specimens were derived from 1,066 deceased subjects (mean age-at-death = 88 years, 65% women) participating in a cohort study of aging. Microinfarcts were classified by number, age and location. Severity of vessel pathologies was graded semi-quantitatively. Almost a third of subjects (n = 300; 28%) had at least one chronic microinfarct, including 128 cortical only, 120 subcortical only, and 47 with both. Moderate-to-severe atherosclerosis was present in 430 (41%) subjects, arteriolosclerosis in 382 (36%), and amyloid angiopathy in 374 (35%). The odds of one or multiple microinfarct(s) was increased for more severe atherosclerosis (OR =1.22; 95%CI: 1.03-1.45), arteriolosclerosis (OR =1.18; 95%CI: 1.02-1.37) and amyloid angiopathy (OR =1.13; 95%CI: 1.00-1.28). Separately, the odds of subcortical microinfarct(s) was increased for atherosclerosis (OR =1.49; 95%CI: 1.20-1.84) and arteriolosclerosis (OR =1.39; 95%CI: 1.16-1.67) but not amyloid angiopathy; whereas the odds of cortical microinfarct(s) was increased for amyloid angiopathy (OR =1.26; 95%CI: 1.09-1.46) only. While cerebral vessel pathologies are associated with microinfarct burden, atherosclerosis and arteriolosclerosis are associated with subcortical microinfarcts, and amyloid angiopathy with cortical microinfarcts.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL. Department of Pathology, Rush University Medical Center, Chicago, IL.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26844934

Citation

Arvanitakis, Zoe, et al. "The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts." Brain Pathology (Zurich, Switzerland), vol. 27, no. 1, 2017, pp. 77-85.
Arvanitakis Z, Capuano AW, Leurgans SE, et al. The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. Brain Pathol. 2017;27(1):77-85.
Arvanitakis, Z., Capuano, A. W., Leurgans, S. E., Buchman, A. S., Bennett, D. A., & Schneider, J. A. (2017). The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. Brain Pathology (Zurich, Switzerland), 27(1), 77-85. https://doi.org/10.1111/bpa.12365
Arvanitakis Z, et al. The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. Brain Pathol. 2017;27(1):77-85. PubMed PMID: 26844934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. AU - Arvanitakis,Zoe, AU - Capuano,Ana W, AU - Leurgans,Sue E, AU - Buchman,Aron S, AU - Bennett,David A, AU - Schneider,Julie A, Y1 - 2016/04/14/ PY - 2015/09/12/received PY - 2016/01/29/accepted PY - 2016/2/5/pubmed PY - 2018/2/24/medline PY - 2016/2/5/entrez KW - atherosclerosis KW - brain KW - cerebrovascular disease KW - epidemiology KW - infarction KW - pathology SP - 77 EP - 85 JF - Brain pathology (Zurich, Switzerland) JO - Brain Pathol. VL - 27 IS - 1 N2 - The relationship of cerebral vessel pathology to brain microinfarcts is not fully understood. We examined associations of cerebral vessel pathology with microinfarcts among community-dwelling persons who came to autopsy. Brain specimens were derived from 1,066 deceased subjects (mean age-at-death = 88 years, 65% women) participating in a cohort study of aging. Microinfarcts were classified by number, age and location. Severity of vessel pathologies was graded semi-quantitatively. Almost a third of subjects (n = 300; 28%) had at least one chronic microinfarct, including 128 cortical only, 120 subcortical only, and 47 with both. Moderate-to-severe atherosclerosis was present in 430 (41%) subjects, arteriolosclerosis in 382 (36%), and amyloid angiopathy in 374 (35%). The odds of one or multiple microinfarct(s) was increased for more severe atherosclerosis (OR =1.22; 95%CI: 1.03-1.45), arteriolosclerosis (OR =1.18; 95%CI: 1.02-1.37) and amyloid angiopathy (OR =1.13; 95%CI: 1.00-1.28). Separately, the odds of subcortical microinfarct(s) was increased for atherosclerosis (OR =1.49; 95%CI: 1.20-1.84) and arteriolosclerosis (OR =1.39; 95%CI: 1.16-1.67) but not amyloid angiopathy; whereas the odds of cortical microinfarct(s) was increased for amyloid angiopathy (OR =1.26; 95%CI: 1.09-1.46) only. While cerebral vessel pathologies are associated with microinfarct burden, atherosclerosis and arteriolosclerosis are associated with subcortical microinfarcts, and amyloid angiopathy with cortical microinfarcts. SN - 1750-3639 UR - https://www.unboundmedicine.com/medline/citation/26844934/The_Relationship_of_Cerebral_Vessel_Pathology_to_Brain_Microinfarcts_ L2 - https://doi.org/10.1111/bpa.12365 DB - PRIME DP - Unbound Medicine ER -