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Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine.
Curr Top Med Chem. 2016; 16(17):1910-5.CT

Abstract

According to the epidemiological reports published by the World Health Organization, the proportion of elderly people (over 60 years) will increase from 11% to 22% by 2050 worldwide. This increase will be associated with a growing rate of morbidity and mortality of age-related diseases. Mental and neurodegenerative diseases are important health problems in elderly people. Therefore, recent research has been focused on finding effective neuroprotective agents with low adverse effects. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel therapeutic agents for treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Among them, flavonoid chemical class is known as one of the most bioactive and non-toxic phytochemicals, which are widely found in different herbal medicines and edible plants. Fisetin is one of the most common and bioactive flavonoids which possesses potential neuroprotective effects. Fisetin also enhances learning and memory, decreases neuronal cell death, and suppresses oxidative stress. The present paper aims to critically evaluate the available literature regarding the beneficial effects of fisetin on neurodegenerative diseases, especially AD and PD. In addition, we provide information regarding the chemistry, sources, bioavailability and clinical impacts of fisetin to provide a broad spectrum for the use of this compound as a new approach to the treatment of AD and PD.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran. Nabavi208@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26845554

Citation

Nabavi, Seyed Fazel, et al. "Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine." Current Topics in Medicinal Chemistry, vol. 16, no. 17, 2016, pp. 1910-5.
Nabavi SF, Braidy N, Habtemariam S, et al. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-5.
Nabavi, S. F., Braidy, N., Habtemariam, S., Sureda, A., Manayi, A., & Nabavi, S. M. (2016). Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Current Topics in Medicinal Chemistry, 16(17), 1910-5.
Nabavi SF, et al. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-5. PubMed PMID: 26845554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. AU - Nabavi,Seyed Fazel, AU - Braidy,Nady, AU - Habtemariam,Solomon, AU - Sureda,Antoni, AU - Manayi,Azadeh, AU - Nabavi,Seyed Mohammad, PY - 2015/05/05/received PY - 2015/07/13/revised PY - 2015/08/02/accepted PY - 2016/2/5/entrez PY - 2016/2/5/pubmed PY - 2017/2/2/medline SP - 1910 EP - 5 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 16 IS - 17 N2 - According to the epidemiological reports published by the World Health Organization, the proportion of elderly people (over 60 years) will increase from 11% to 22% by 2050 worldwide. This increase will be associated with a growing rate of morbidity and mortality of age-related diseases. Mental and neurodegenerative diseases are important health problems in elderly people. Therefore, recent research has been focused on finding effective neuroprotective agents with low adverse effects. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel therapeutic agents for treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Among them, flavonoid chemical class is known as one of the most bioactive and non-toxic phytochemicals, which are widely found in different herbal medicines and edible plants. Fisetin is one of the most common and bioactive flavonoids which possesses potential neuroprotective effects. Fisetin also enhances learning and memory, decreases neuronal cell death, and suppresses oxidative stress. The present paper aims to critically evaluate the available literature regarding the beneficial effects of fisetin on neurodegenerative diseases, especially AD and PD. In addition, we provide information regarding the chemistry, sources, bioavailability and clinical impacts of fisetin to provide a broad spectrum for the use of this compound as a new approach to the treatment of AD and PD. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/26845554/Neuroprotective_Effects_of_Fisetin_in_Alzheimer's_and_Parkinson's_Diseases:_From_Chemistry_to_Medicine_ DB - PRIME DP - Unbound Medicine ER -