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Sleep disorders increase risk of subsequent erectile dysfunction in individuals without sleep apnea: a nationwide population-base cohort study.
Sleep Med. 2016 Jan; 17:64-8.SM

Abstract

BACKGROUND

Sleep disorders (SD) and erectile dysfunction (ED) both play crucial roles in quality of life and have received increasing attention in the general population and among physicians.

METHODS

This study investigated the risk of ED in people diagnosed with SD compared with that in age- and sex-matched unaffected people. This longitudinal, nationwide, population-based cohort study was conducted using data in the Taiwan National Health Insurance Research Database (NHIRD) from January 1998 to December 2011. The sample consisted of 603 people with sleep apnea, 17,182 people with non-apnea SD, and 35,570 matched comparisons as controls. A Cox proportional hazard regression was used to compute the risk of ED in people with SD relative to that in people without SD.

RESULTS

The ED incidences were 9.44-fold higher (95% CI 6.49-13.7) in the sleep apnea cohort and 3.72-fold higher (95% CI 3.13-4.41) in the non-apnea SD cohort than in the control cohort, respectively, after age, sex, and comorbidities were adjusted for. The incidence of ED was higher in younger adults (adjusted hazard ratio (HR), 10.4 (95% CI 5.93-18.4) in the sleep apnea cohort and adjusted HR, 4.20 (95% CI 3.07-5.76) in non-apnea SD cohort) and those using benzodiazepine (adjusted HR, 9.69 (95% CI 5.48-10.6) in the sleep apnea cohort and adjusted HR, and 3.83 (95% CI 3.20-4.59) in the non-apnea SD cohort).

CONCLUSION

This nationwide population-based cohort study provides evidence that people with SD, particularly those with sleep apnea, exhibit an increased risk of subsequent ED.

Authors+Show Affiliations

Department of Neurology, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan.China Medical University, Taichung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.China Medical University, Taichung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address: d10040@mail.cmuh.org.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26847976

Citation

Chen, Kuan-Fei, et al. "Sleep Disorders Increase Risk of Subsequent Erectile Dysfunction in Individuals Without Sleep Apnea: a Nationwide Population-base Cohort Study." Sleep Medicine, vol. 17, 2016, pp. 64-8.
Chen KF, Liang SJ, Lin CL, et al. Sleep disorders increase risk of subsequent erectile dysfunction in individuals without sleep apnea: a nationwide population-base cohort study. Sleep Med. 2016;17:64-8.
Chen, K. F., Liang, S. J., Lin, C. L., Liao, W. C., & Kao, C. H. (2016). Sleep disorders increase risk of subsequent erectile dysfunction in individuals without sleep apnea: a nationwide population-base cohort study. Sleep Medicine, 17, 64-8. https://doi.org/10.1016/j.sleep.2015.05.018
Chen KF, et al. Sleep Disorders Increase Risk of Subsequent Erectile Dysfunction in Individuals Without Sleep Apnea: a Nationwide Population-base Cohort Study. Sleep Med. 2016;17:64-8. PubMed PMID: 26847976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep disorders increase risk of subsequent erectile dysfunction in individuals without sleep apnea: a nationwide population-base cohort study. AU - Chen,Kuan-Fei, AU - Liang,Shinn-Jye, AU - Lin,Cheng-Li, AU - Liao,Wei-Chih, AU - Kao,Chia-Hung, Y1 - 2015/06/29/ PY - 2015/02/03/received PY - 2015/04/08/revised PY - 2015/05/10/accepted PY - 2016/2/6/entrez PY - 2016/2/6/pubmed PY - 2016/12/15/medline KW - Cohort study KW - Erectile dysfunction KW - Sleep disorder KW - Taiwan National Health Insurance Research Database (NHIRD) SP - 64 EP - 8 JF - Sleep medicine JO - Sleep Med VL - 17 N2 - BACKGROUND: Sleep disorders (SD) and erectile dysfunction (ED) both play crucial roles in quality of life and have received increasing attention in the general population and among physicians. METHODS: This study investigated the risk of ED in people diagnosed with SD compared with that in age- and sex-matched unaffected people. This longitudinal, nationwide, population-based cohort study was conducted using data in the Taiwan National Health Insurance Research Database (NHIRD) from January 1998 to December 2011. The sample consisted of 603 people with sleep apnea, 17,182 people with non-apnea SD, and 35,570 matched comparisons as controls. A Cox proportional hazard regression was used to compute the risk of ED in people with SD relative to that in people without SD. RESULTS: The ED incidences were 9.44-fold higher (95% CI 6.49-13.7) in the sleep apnea cohort and 3.72-fold higher (95% CI 3.13-4.41) in the non-apnea SD cohort than in the control cohort, respectively, after age, sex, and comorbidities were adjusted for. The incidence of ED was higher in younger adults (adjusted hazard ratio (HR), 10.4 (95% CI 5.93-18.4) in the sleep apnea cohort and adjusted HR, 4.20 (95% CI 3.07-5.76) in non-apnea SD cohort) and those using benzodiazepine (adjusted HR, 9.69 (95% CI 5.48-10.6) in the sleep apnea cohort and adjusted HR, and 3.83 (95% CI 3.20-4.59) in the non-apnea SD cohort). CONCLUSION: This nationwide population-based cohort study provides evidence that people with SD, particularly those with sleep apnea, exhibit an increased risk of subsequent ED. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/26847976/Sleep_disorders_increase_risk_of_subsequent_erectile_dysfunction_in_individuals_without_sleep_apnea:_a_nationwide_population_base_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(15)00821-7 DB - PRIME DP - Unbound Medicine ER -