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Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils.
J Hazard Mater. 2016 May 05; 308:312-20.JH

Abstract

Individual and combined effects of enrofloxacin (EF) and cadmium (Cd) on the earthworm Eisenia fetida at environmentally relevant concentrations were investigated. EF is a veterinary antibiotic; Cd is an impurity in phosphatic fertiliser. For both, residues may accumulate in farm soils. In laboratory tests, over 98% of spiked EF was adsorbed by farm soils, with a half-life >8 weeks. However, earthworms absorbed less than 20% of spiked EF. Earthworms in soil with EF concentration 10 mg kg(-1) soil experienced transient oxidative stress and exhibited reduced burrowing activity and respiration after an 8-week exposure; EF at 0.1 and 1.0 mg kg(-1) soil did not elicit toxicity symptoms. When both were added, Cd did not affect EF uptake, but each increment of spiked EF increased Cd bioaccumulation and associated oxidative stress of earthworms, and also caused decreased burrow length and CO2 production. However, metallothionein induction was not affected. The enhanced toxicity of Cd to earthworms in the presence of EF at low environmental concentrations may have implications for the health and reproductive success of earthworm populations and highlights the importance of understanding effects of antibiotic contamination of farm soils, and of awareness of environmental effects from interaction between multiple contaminants.

Authors+Show Affiliations

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: yinshengli@sjtu.edu.cn.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.Institute of Agriculture & Environment, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand.Landcare Research, PO Box 40, Lincoln 7640, New Zealand.School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26852206

Citation

Li, Yinsheng, et al. "Enrofloxacin at Environmentally Relevant Concentrations Enhances Uptake and Toxicity of Cadmium in the Earthworm Eisenia Fetida in Farm Soils." Journal of Hazardous Materials, vol. 308, 2016, pp. 312-20.
Li Y, Tang H, Hu Y, et al. Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils. J Hazard Mater. 2016;308:312-20.
Li, Y., Tang, H., Hu, Y., Wang, X., Ai, X., Tang, L., Matthew, C., Cavanagh, J., & Qiu, J. (2016). Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils. Journal of Hazardous Materials, 308, 312-20. https://doi.org/10.1016/j.jhazmat.2016.01.057
Li Y, et al. Enrofloxacin at Environmentally Relevant Concentrations Enhances Uptake and Toxicity of Cadmium in the Earthworm Eisenia Fetida in Farm Soils. J Hazard Mater. 2016 May 5;308:312-20. PubMed PMID: 26852206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enrofloxacin at environmentally relevant concentrations enhances uptake and toxicity of cadmium in the earthworm Eisenia fetida in farm soils. AU - Li,Yinsheng, AU - Tang,Hao, AU - Hu,Yingxiu, AU - Wang,Xiuhong, AU - Ai,Xiaojie, AU - Tang,Li, AU - Matthew,Cory, AU - Cavanagh,Jo, AU - Qiu,Jiangping, Y1 - 2016/01/25/ PY - 2015/09/21/received PY - 2016/01/21/revised PY - 2016/01/23/accepted PY - 2016/2/8/entrez PY - 2016/2/8/pubmed PY - 2016/12/15/medline KW - Bioaccumulation KW - Cadmium KW - Earthworm KW - Enrofloxacin KW - Molecular toxicity SP - 312 EP - 20 JF - Journal of hazardous materials JO - J Hazard Mater VL - 308 N2 - Individual and combined effects of enrofloxacin (EF) and cadmium (Cd) on the earthworm Eisenia fetida at environmentally relevant concentrations were investigated. EF is a veterinary antibiotic; Cd is an impurity in phosphatic fertiliser. For both, residues may accumulate in farm soils. In laboratory tests, over 98% of spiked EF was adsorbed by farm soils, with a half-life >8 weeks. However, earthworms absorbed less than 20% of spiked EF. Earthworms in soil with EF concentration 10 mg kg(-1) soil experienced transient oxidative stress and exhibited reduced burrowing activity and respiration after an 8-week exposure; EF at 0.1 and 1.0 mg kg(-1) soil did not elicit toxicity symptoms. When both were added, Cd did not affect EF uptake, but each increment of spiked EF increased Cd bioaccumulation and associated oxidative stress of earthworms, and also caused decreased burrow length and CO2 production. However, metallothionein induction was not affected. The enhanced toxicity of Cd to earthworms in the presence of EF at low environmental concentrations may have implications for the health and reproductive success of earthworm populations and highlights the importance of understanding effects of antibiotic contamination of farm soils, and of awareness of environmental effects from interaction between multiple contaminants. SN - 1873-3336 UR - https://www.unboundmedicine.com/medline/citation/26852206/Enrofloxacin_at_environmentally_relevant_concentrations_enhances_uptake_and_toxicity_of_cadmium_in_the_earthworm_Eisenia_fetida_in_farm_soils_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3894(16)30057-7 DB - PRIME DP - Unbound Medicine ER -