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Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma.
Kaohsiung J Med Sci. 2016 Jan; 32(1):38-43.KJ

Abstract

In our study we aimed to evaluate the short-term effects of dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with pseudoexfoliative glaucoma (PXG). This prospective observational cross-sectional study enrolled 22 eyes of 22 newly-diagnosed patients with PXG in a single center. All of the patients received a fixed combination of dorzolamide/timolol. Besides routine ophthalmologic examination, the retrobulbar hemodynamic parameters in the ophthalmic artery, central retinal artery, and short posterior ciliary arteries were measured in all participants at baseline and the 3(rd) month using color Doppler imaging. The mean intraocular pressure (IOP) was 22.3 ± 2.1 mmHg at baseline and reduced to 17.4 ± 2.3 mmHg at the 3(rd) month (p < 0.05). None of the retrobulbar parameters, except peak systolic velocity and resistive index in temporal short posterior ciliary arteries, changed significantly on therapy with dorzolamide/timolol fixed combination when the results were analyzed at Month 3. The drug significantly decreased the peak systolic velocity (p = 0.044) and reduced the resistive index in 0.04 units, 95% confidence interval 0.03-0.05, (p < 0.001) in the temporal short posterior ciliary arteries. This study reports that the retrobulbar hemodynamics might be affected less than expected by dorzolamide/timolol fixed combination in patients with PXG although the reduction of IOP was statistically significant.

Authors+Show Affiliations

Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey. Electronic address: drmustafaeliacik@gmail.com.Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.Department of Radiology, Istanbul Medipol University, School of Medicine, Turkey.Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

26853174

Citation

Eliacik, Mustafa, et al. "Effects of Dorzolamide/timolol Fixed Combination On Retrobulbar Hemodynamics in Pseudoexfoliative Glaucoma." The Kaohsiung Journal of Medical Sciences, vol. 32, no. 1, 2016, pp. 38-43.
Eliacik M, Karaman Erdur S, Baltepe Altıok I, et al. Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma. Kaohsiung J Med Sci. 2016;32(1):38-43.
Eliacik, M., Karaman Erdur, S., Baltepe Altıok, I., Gulkilik, G., Aslan, C. A., & Kaya, F. (2016). Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma. The Kaohsiung Journal of Medical Sciences, 32(1), 38-43. https://doi.org/10.1016/j.kjms.2015.12.004
Eliacik M, et al. Effects of Dorzolamide/timolol Fixed Combination On Retrobulbar Hemodynamics in Pseudoexfoliative Glaucoma. Kaohsiung J Med Sci. 2016;32(1):38-43. PubMed PMID: 26853174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma. AU - Eliacik,Mustafa, AU - Karaman Erdur,Sevil, AU - Baltepe Altıok,Inci, AU - Gulkilik,Gokhan, AU - Aslan,Cemile Anil, AU - Kaya,Faruk, Y1 - 2016/01/23/ PY - 2015/08/12/received PY - 2015/12/02/revised PY - 2015/12/18/accepted PY - 2016/2/9/entrez PY - 2016/2/9/pubmed PY - 2017/1/12/medline KW - Color Doppler imaging KW - Dorzolamide/timolol KW - Glaucoma KW - Pseudoexfoliation KW - Retrobulbar ocular blood flow SP - 38 EP - 43 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J Med Sci VL - 32 IS - 1 N2 - In our study we aimed to evaluate the short-term effects of dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with pseudoexfoliative glaucoma (PXG). This prospective observational cross-sectional study enrolled 22 eyes of 22 newly-diagnosed patients with PXG in a single center. All of the patients received a fixed combination of dorzolamide/timolol. Besides routine ophthalmologic examination, the retrobulbar hemodynamic parameters in the ophthalmic artery, central retinal artery, and short posterior ciliary arteries were measured in all participants at baseline and the 3(rd) month using color Doppler imaging. The mean intraocular pressure (IOP) was 22.3 ± 2.1 mmHg at baseline and reduced to 17.4 ± 2.3 mmHg at the 3(rd) month (p < 0.05). None of the retrobulbar parameters, except peak systolic velocity and resistive index in temporal short posterior ciliary arteries, changed significantly on therapy with dorzolamide/timolol fixed combination when the results were analyzed at Month 3. The drug significantly decreased the peak systolic velocity (p = 0.044) and reduced the resistive index in 0.04 units, 95% confidence interval 0.03-0.05, (p < 0.001) in the temporal short posterior ciliary arteries. This study reports that the retrobulbar hemodynamics might be affected less than expected by dorzolamide/timolol fixed combination in patients with PXG although the reduction of IOP was statistically significant. SN - 2410-8650 UR - https://www.unboundmedicine.com/medline/citation/26853174/Effects_of_dorzolamide/timolol_fixed_combination_on_retrobulbar_hemodynamics_in_pseudoexfoliative_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1607-551X(15)00280-6 DB - PRIME DP - Unbound Medicine ER -