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Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping.
NMR Biomed. 2017 Apr; 30(4)NB

Abstract

The progression of Parkinson's disease (PD) seems to vary according to the disease stage, which greatly influences the management of PD patients. However, the underlying mechanism of progression in PD remains unclear. This study was designed to explore the progressive pattern of iron accumulation at different stages in PD patients. Sixty right-handed PD patients and 40 normal controls were recruited. According to the disease stage, 45 patients with Hoehn-Yahr stage ≤ 2.5 and 15 patients with Hoehn-Yahr stage ≥ 3 were grouped into early-stage PD (EPD) and late-stage PD (LPD) groups, respectively. The iron content in the cardinal subcortical nuclei covering the cerebrum, cerebellum and midbrain was measured using quantitative susceptibility mapping (QSM). The substantia nigra pars compacta (SNc) showed significantly increased QSM values in the EPD patients compared with the controls. In the LPD patients, while the SNc continued to show increased QSM values compared with the controls and EPD patients, the regions showing increased QSM values spread to include the substantia nigra pars reticulata (SNr), red nucleus (RN) and globus pallidus (GP). Our data also indicated that iron deposition was more significant in the GP internal segment (GPi) than in the GP external segment. No other regions showed significant changes in QSM values among the groups. Therefore, we were able to confirm a regionally progressive pattern of iron accumulation in the different stages of PD, indicating that iron deposition in the SNc is affected exclusively in the early stages of the disease, while the SNr, RN and GP, and particularly the GPi segment, become involved in advanced stages of the disease. This is a preliminary study providing objective evidence of the iron-related progression in PD. Copyright © 2016 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, North Carolina, USA. Department of Radiology, Duke University School of Medicine, Durham, North Carolina, USA.Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, North Carolina, USA.Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26853890

Citation

Guan, Xiaojun, et al. "Regionally Progressive Accumulation of Iron in Parkinson's Disease as Measured By Quantitative Susceptibility Mapping." NMR in Biomedicine, vol. 30, no. 4, 2017.
Guan X, Xuan M, Gu Q, et al. Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping. NMR Biomed. 2017;30(4).
Guan, X., Xuan, M., Gu, Q., Huang, P., Liu, C., Wang, N., Xu, X., Luo, W., & Zhang, M. (2017). Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping. NMR in Biomedicine, 30(4). https://doi.org/10.1002/nbm.3489
Guan X, et al. Regionally Progressive Accumulation of Iron in Parkinson's Disease as Measured By Quantitative Susceptibility Mapping. NMR Biomed. 2017;30(4) PubMed PMID: 26853890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping. AU - Guan,Xiaojun, AU - Xuan,Min, AU - Gu,Quanquan, AU - Huang,Peiyu, AU - Liu,Chunlei, AU - Wang,Nian, AU - Xu,Xiaojun, AU - Luo,Wei, AU - Zhang,Minming, Y1 - 2016/02/08/ PY - 2015/10/10/received PY - 2015/12/11/revised PY - 2015/12/28/accepted PY - 2016/2/9/pubmed PY - 2018/1/9/medline PY - 2016/2/9/entrez KW - Parkinson's disease KW - disease stage KW - iron KW - progression KW - quantitative susceptibility mapping JF - NMR in biomedicine JO - NMR Biomed VL - 30 IS - 4 N2 - The progression of Parkinson's disease (PD) seems to vary according to the disease stage, which greatly influences the management of PD patients. However, the underlying mechanism of progression in PD remains unclear. This study was designed to explore the progressive pattern of iron accumulation at different stages in PD patients. Sixty right-handed PD patients and 40 normal controls were recruited. According to the disease stage, 45 patients with Hoehn-Yahr stage ≤ 2.5 and 15 patients with Hoehn-Yahr stage ≥ 3 were grouped into early-stage PD (EPD) and late-stage PD (LPD) groups, respectively. The iron content in the cardinal subcortical nuclei covering the cerebrum, cerebellum and midbrain was measured using quantitative susceptibility mapping (QSM). The substantia nigra pars compacta (SNc) showed significantly increased QSM values in the EPD patients compared with the controls. In the LPD patients, while the SNc continued to show increased QSM values compared with the controls and EPD patients, the regions showing increased QSM values spread to include the substantia nigra pars reticulata (SNr), red nucleus (RN) and globus pallidus (GP). Our data also indicated that iron deposition was more significant in the GP internal segment (GPi) than in the GP external segment. No other regions showed significant changes in QSM values among the groups. Therefore, we were able to confirm a regionally progressive pattern of iron accumulation in the different stages of PD, indicating that iron deposition in the SNc is affected exclusively in the early stages of the disease, while the SNr, RN and GP, and particularly the GPi segment, become involved in advanced stages of the disease. This is a preliminary study providing objective evidence of the iron-related progression in PD. Copyright © 2016 John Wiley & Sons, Ltd. SN - 1099-1492 UR - https://www.unboundmedicine.com/medline/citation/26853890/Regionally_progressive_accumulation_of_iron_in_Parkinson's_disease_as_measured_by_quantitative_susceptibility_mapping_ L2 - https://doi.org/10.1002/nbm.3489 DB - PRIME DP - Unbound Medicine ER -