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HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study.
Atherosclerosis. 2016 Apr; 247:1-6.A

Abstract

OBJECTIVES

We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population.

METHODS

A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultrasound was used to evaluate carotid artery structure, including intima-media thickness (IMT), plaque, and luminal diameter. Brachial-ankle pulse wave velocity (baPWV), which is a useful indicator of systemic arterial stiffness, was determined using an automatic waveform analysis device.

RESULTS

No significant associations were observed between HbA1c, carotid IMT, plaque, or luminal diameter in a fully adjusted model. However, the odds ratio (95% confidence interval) for high baPWV (defined as the highest quartile) increased by 1.43 (1.19-1.71) per 1% HbA1c increase after adjusting for conventional risk factors in a multivariate logistic regression analysis. In addition, HbA1c was independently associated with baPWV in a multivariate linear regression analysis.

CONCLUSIONS

High-normal HbA1c level was independently associated with arterial stiffness, but not with carotid atherosclerotic parameters, in the general population without diabetes. Our results suggest that the functional atherosclerotic process may already be accelerated according to HbA1c level, even at a level below the diagnostic threshold for diabetes.

Authors+Show Affiliations

Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeonbuk, South Korea; Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Jeonbuk, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, South Korea.Department of Neurology, Chonbuk National University Medical School-Chonbuk National University Hospital, Jeonju, Jeonbuk, South Korea.Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Jeonbuk, South Korea.Department of Preventive Medicine, Chosun University Medical School, Gwangju, South Korea.Department of Preventive Medicine, Chosun University Medical School, Gwangju, South Korea.Department of Food & Nutrition, Chosun University College of Natural Sciences, Gwangju, South Korea.Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Jeonbuk, South Korea; Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Jeonbuk, South Korea.Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea. Electronic address: ujingogo@paran.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26854970

Citation

Lee, Young-Hoon, et al. "HbA1c Is Significantly Associated With Arterial Stiffness but Not With Carotid Atherosclerosis in a Community-based Population Without Type 2 Diabetes: the Dong-gu Study." Atherosclerosis, vol. 247, 2016, pp. 1-6.
Lee YH, Shin MH, Choi JS, et al. HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study. Atherosclerosis. 2016;247:1-6.
Lee, Y. H., Shin, M. H., Choi, J. S., Rhee, J. A., Nam, H. S., Jeong, S. K., Park, K. S., Ryu, S. Y., Choi, S. W., Kim, B. H., Oh, G. J., & Kweon, S. S. (2016). HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study. Atherosclerosis, 247, 1-6. https://doi.org/10.1016/j.atherosclerosis.2016.01.032
Lee YH, et al. HbA1c Is Significantly Associated With Arterial Stiffness but Not With Carotid Atherosclerosis in a Community-based Population Without Type 2 Diabetes: the Dong-gu Study. Atherosclerosis. 2016;247:1-6. PubMed PMID: 26854970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study. AU - Lee,Young-Hoon, AU - Shin,Min-Ho, AU - Choi,Jin-Su, AU - Rhee,Jung-Ae, AU - Nam,Hae-Sung, AU - Jeong,Seul-Ki, AU - Park,Kyeong-Soo, AU - Ryu,So-Yeon, AU - Choi,Seong-Woo, AU - Kim,Bok-Hee, AU - Oh,Gyung-Jae, AU - Kweon,Sun-Seog, Y1 - 2016/01/21/ PY - 2015/06/04/received PY - 2015/12/15/revised PY - 2016/01/19/accepted PY - 2016/2/9/entrez PY - 2016/2/9/pubmed PY - 2016/12/27/medline KW - Arterial stiffness KW - Carotid atherosclerosis KW - Cross-sectional studies KW - Glycosylated KW - Hemoglobin A SP - 1 EP - 6 JF - Atherosclerosis JO - Atherosclerosis VL - 247 N2 - OBJECTIVES: We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population. METHODS: A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mode ultrasound was used to evaluate carotid artery structure, including intima-media thickness (IMT), plaque, and luminal diameter. Brachial-ankle pulse wave velocity (baPWV), which is a useful indicator of systemic arterial stiffness, was determined using an automatic waveform analysis device. RESULTS: No significant associations were observed between HbA1c, carotid IMT, plaque, or luminal diameter in a fully adjusted model. However, the odds ratio (95% confidence interval) for high baPWV (defined as the highest quartile) increased by 1.43 (1.19-1.71) per 1% HbA1c increase after adjusting for conventional risk factors in a multivariate logistic regression analysis. In addition, HbA1c was independently associated with baPWV in a multivariate linear regression analysis. CONCLUSIONS: High-normal HbA1c level was independently associated with arterial stiffness, but not with carotid atherosclerotic parameters, in the general population without diabetes. Our results suggest that the functional atherosclerotic process may already be accelerated according to HbA1c level, even at a level below the diagnostic threshold for diabetes. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/26854970/HbA1c_is_significantly_associated_with_arterial_stiffness_but_not_with_carotid_atherosclerosis_in_a_community_based_population_without_type_2_diabetes:_The_Dong_gu_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(16)30031-4 DB - PRIME DP - Unbound Medicine ER -