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Clinical and molecular features of young-onset colorectal cancer.
World J Gastroenterol. 2016 Feb 07; 22(5):1736-44.WJ

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression.

Authors+Show Affiliations

Veroushka Ballester, Shahrooz Rashtak, Lisa Boardman, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.Veroushka Ballester, Shahrooz Rashtak, Lisa Boardman, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.Veroushka Ballester, Shahrooz Rashtak, Lisa Boardman, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26855533

Citation

Ballester, Veroushka, et al. "Clinical and Molecular Features of Young-onset Colorectal Cancer." World Journal of Gastroenterology, vol. 22, no. 5, 2016, pp. 1736-44.
Ballester V, Rashtak S, Boardman L. Clinical and molecular features of young-onset colorectal cancer. World J Gastroenterol. 2016;22(5):1736-44.
Ballester, V., Rashtak, S., & Boardman, L. (2016). Clinical and molecular features of young-onset colorectal cancer. World Journal of Gastroenterology, 22(5), 1736-44. https://doi.org/10.3748/wjg.v22.i5.1736
Ballester V, Rashtak S, Boardman L. Clinical and Molecular Features of Young-onset Colorectal Cancer. World J Gastroenterol. 2016 Feb 7;22(5):1736-44. PubMed PMID: 26855533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and molecular features of young-onset colorectal cancer. AU - Ballester,Veroushka, AU - Rashtak,Shahrooz, AU - Boardman,Lisa, PY - 2015/07/09/received PY - 2015/10/25/revised PY - 2015/12/14/accepted PY - 2016/2/9/entrez PY - 2016/2/9/pubmed PY - 2017/1/18/medline KW - Chromosomal instability KW - Chromosome stable colorectal cancer KW - CpG island methylator phenotype KW - Late-onset colorectal cancer KW - Microsatellite KW - Microsatellite instability KW - Young-onset colorectal cancer SP - 1736 EP - 44 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 22 IS - 5 N2 - Colorectal cancer (CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26855533/Clinical_and_molecular_features_of_young_onset_colorectal_cancer_ L2 - https://www.wjgnet.com/1007-9327/full/v22/i5/1736.htm DB - PRIME DP - Unbound Medicine ER -