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Motor complications associated with chronic levodopa therapy in Parkinson's disease.
Neurology. 1989 Nov; 39(11 Suppl 2):11-9.Neur

Abstract

Fluctuations and dyskinesias are the 2 main motor complications associated with chronic levodopa therapy. Striatal denervation following degeneration of the substantia nigra dopaminergic projections is probably the major pathophysiologic mechanism underlying motor fluctuations. In addition, pathologic modification of striatal receptors, partially related to the nonphysiologic delivery of levodopa in a discontinuous pulsatile mode, may be responsible for the various types of dyskinesias and sudden "off" episodes. Drugs capable of providing a stable dopaminergic stimulation should be particularly useful for preventing the development of motor complications in patients not yet treated. At the other end of the clinical spectrum, patients with complex fluctuations are the least likely to improve with slow-release levodopa preparations.

Authors+Show Affiliations

Department of Neurology, Clinica Universitaria, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2685647

Citation

Obeso, J A., et al. "Motor Complications Associated With Chronic Levodopa Therapy in Parkinson's Disease." Neurology, vol. 39, no. 11 Suppl 2, 1989, pp. 11-9.
Obeso JA, Grandas F, Vaamonde J, et al. Motor complications associated with chronic levodopa therapy in Parkinson's disease. Neurology. 1989;39(11 Suppl 2):11-9.
Obeso, J. A., Grandas, F., Vaamonde, J., Luquin, M. R., Artieda, J., Lera, G., Rodriguez, M. E., & Martinez-Lage, J. M. (1989). Motor complications associated with chronic levodopa therapy in Parkinson's disease. Neurology, 39(11 Suppl 2), 11-9.
Obeso JA, et al. Motor Complications Associated With Chronic Levodopa Therapy in Parkinson's Disease. Neurology. 1989;39(11 Suppl 2):11-9. PubMed PMID: 2685647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor complications associated with chronic levodopa therapy in Parkinson's disease. AU - Obeso,J A, AU - Grandas,F, AU - Vaamonde,J, AU - Luquin,M R, AU - Artieda,J, AU - Lera,G, AU - Rodriguez,M E, AU - Martinez-Lage,J M, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 11 EP - 9 JF - Neurology JO - Neurology VL - 39 IS - 11 Suppl 2 N2 - Fluctuations and dyskinesias are the 2 main motor complications associated with chronic levodopa therapy. Striatal denervation following degeneration of the substantia nigra dopaminergic projections is probably the major pathophysiologic mechanism underlying motor fluctuations. In addition, pathologic modification of striatal receptors, partially related to the nonphysiologic delivery of levodopa in a discontinuous pulsatile mode, may be responsible for the various types of dyskinesias and sudden "off" episodes. Drugs capable of providing a stable dopaminergic stimulation should be particularly useful for preventing the development of motor complications in patients not yet treated. At the other end of the clinical spectrum, patients with complex fluctuations are the least likely to improve with slow-release levodopa preparations. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/2685647/Motor_complications_associated_with_chronic_levodopa_therapy_in_Parkinson's_disease_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -